Detalles de la búsqueda
1.
Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII.
J Enzyme Inhib Med Chem;
38(1): 2154603, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36728712
2.
Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity.
J Enzyme Inhib Med Chem;
38(1): 2189097, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36927348
3.
Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities.
Proc Natl Acad Sci U S A;
117(45): 27906-27915, 2020 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33106394
4.
Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole-Pyrimidine Derivatives as Potential Antiproliferative Agents.
Medicina (Kaunas);
59(6)2023 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37374282
5.
Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase.
Molecules;
26(11)2021 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-34073016
6.
Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90.
Int J Mol Sci;
21(24)2020 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33317068
7.
Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study.
Bioorg Med Chem;
26(21): 5596-5611, 2018 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30385226
8.
Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors.
Bioorg Med Chem Lett;
27(2): 237-241, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27914802
9.
Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist.
J Comput Aided Mol Des;
30(8): 625-37, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27600555
10.
Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain.
Bioorg Med Chem Lett;
25(6): 1324-8, 2015 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25677662
11.
Efficient synthesis of mibefradil analogues: an insight into in vitro stability.
Org Biomol Chem;
12(30): 5669-81, 2014 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24964394
12.
Synthesis and in vitro evaluation of the antitubercular and antibacterial activity of novel oxazolidinones bearing octahydrocyclopenta[c]pyrrol-2-yl moieties.
Chem Pharm Bull (Tokyo);
62(12): 1214-24, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25297523
13.
Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones.
Bioorg Med Chem Lett;
23(5): 1193-6, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23385213
14.
Exploration of Tetrahydroisoquinoline- and Benzo[c]azepine-Based Sphingosine 1-Phosphate Receptor 1 Agonists for the Treatment of Multiple Sclerosis.
J Med Chem;
66(15): 10381-10412, 2023 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37489798
15.
Development of Dibenzothiazepine Derivatives as Multifunctional Compounds for Neuropathic Pain.
Pharmaceuticals (Basel);
15(4)2022 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35455404
16.
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis.
J Med Chem;
65(4): 3539-3562, 2022 02 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35077170
17.
Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors.
Bioorg Med Chem Lett;
21(6): 1593-7, 2011 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21353544
18.
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers.
Bioorg Med Chem Lett;
21(1): 215-9, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21126876
19.
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.
Bioorg Med Chem Lett;
21(19): 5910-5, 2011 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21843937
20.
Structure based design of heat shock protein 90 inhibitors acting as anticancer agents.
Bioorg Med Chem;
19(5): 1714-20, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21306907