The effect of some beta -adrenergic blocking agents on ovulation in rabbits.

PIP: The effect of propanolol hydrochloride (PH) and oxprenolol hydrochloride (OH) on ovulation was studied in mature rabbits. PH-treated animals did not accept mating and ovulation was suppressed after forced mating. 5 of 6 OH-treated animals refused mating. No implantation sites or corpora lutea were found in the animal that did accept mating. Forced mating did not prevent ovulation in OH-treated animals. Both PH and OH did not inhibit ovulation in animals treated with 200 IU of chorionic gonadotropin. The possible modes of action of the 2 beta-adrenergic blocking agents is discussed.^ieng