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1.
J Environ Manage ; 359: 121084, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38723505

RESUMEN

Extensive global dependency on rice and wheat crops has necessitated the adoption of intensive cultivation practices, thereby compelling to closely monitor the potential yield-limiting factors, among which, boron (B) deficiency stands out to be a prime concern. The present study explores the effects of B fertilization strategies within the Rice-Wheat Cropping System (RWCS) in the Tarai region of North-West India. A comprehensive six-year field experiment was conducted (2013-2019) at G.B. Pant University of Agriculture and Technology, Uttarakhand, India. The experiment tested graded B doses (0.5, 1.0, 1.5, and 2.0 kg ha-1) at varied frequencies (single, alternate, and annual) in a factorial design. The study revealed significant impacts of alternate B application at 1.5 kg ha-1 on crop yields and the Sustainable Yield Index (SYI). The System Rice Equivalent Yield (SREY) exhibited an increase of 6.7% with B supplementation over B-deprived plots, highlighting the pivotal role of B fertilizer in enhancing productivity within the RWCS. The economic optimum B dose was found to be 1.422 kg ha-1 using a linear plus plateau model, resulting in a calculated annual SREY of 9.73 t ha-1 when applied alternately to the cropping system. Continuous application and higher B rates demonstrated substantial increases in various B fractions, while the mobility factor remained within 10%, depicting safe ecological limits. The distribution of fractions in B-treated plots on average followed the order: residual B > organically-bound B > oxide bound B > specifically adsorbed B > readily soluble B. Similarities in the distribution patterns of B fractions between B-treated plots and the control indicated potential influence of biotic or abiotic processes on B fraction dynamics, even in the absence of external B application. To sum up, B application in alternate years at 1.5 kg ha-1 was most sustainable in enhancing the SREY, SYI, available soil B, and B fractions and lowering the environmental hazards.


Asunto(s)
Agricultura , Boro , Productos Agrícolas , Fertilizantes , Oryza , Triticum , Oryza/crecimiento & desarrollo , Triticum/crecimiento & desarrollo , India , Agricultura/métodos , Productos Agrícolas/crecimiento & desarrollo , Suelo/química
2.
Medicina (Kaunas) ; 59(8)2023 Jul 27.
Artículo en Inglés | MEDLINE | ID: mdl-37629664

RESUMEN

BACKGROUND AND OBJECTIVES: Obstructive sleep apnea-hypopnea syndrome (OSAHS) and chronic obstructive pulmonary disease (COPD) are independently linked to an increase in cardiovascular disease (CVD). Only a few studies have been published linking the association between overlap syndrome and congestive heart failure (CHF). This review highlights the interplay between overlap syndrome (OSAHS-COPD) and CHF. MATERIALS AND METHODS: We thoroughly reviewed published literature from 2005 to 2022 in PubMed, Google Scholar, and Cochrane databases to explore the link between overlap syndrome and cardiovascular outcomes, specifically congestive heart failure. RESULTS: Research indicates that individuals with overlap syndrome are more likely to develop congestive heart failure than those with COPD or OSA alone. Congestive heart failure is a common comorbidity of overlap syndrome, and it has a two-way connection with sleep-related breathing disorders, which tend to occur together more frequently than expected by chance. CONCLUSIONS: CHF seems to have a strong relationship with OS. Further research is required to understand the relationship between OS and CHF.


Asunto(s)
Enfermedades Autoinmunes , Enfermedades Cardiovasculares , Insuficiencia Cardíaca , Enfermedad Pulmonar Obstructiva Crónica , Apnea Obstructiva del Sueño , Trastornos del Sueño-Vigilia , Humanos , Apnea Obstructiva del Sueño/complicaciones , Apnea Obstructiva del Sueño/epidemiología , Síndrome , Insuficiencia Cardíaca/complicaciones , Enfermedad Pulmonar Obstructiva Crónica/complicaciones , Enfermedad Pulmonar Obstructiva Crónica/epidemiología
3.
Environ Monit Assess ; 194(4): 290, 2022 Mar 23.
Artículo en Inglés | MEDLINE | ID: mdl-35320425

RESUMEN

The mountain ecosystem is highly vulnerable to climate changes fraught with a multitude of problems related to environment, food, and nutritional security. Quantification of the soil fertility status can provide an efficient way to devise strategies for sustainable crop production. The lack of information on the soil fertility status prompted us to delineate the spatial variability of the soil attributes, viz., pH, electrical conductivity (EC), soil organic carbon (OC), and the macronutrients (nitrogen (N), phosphorus (P), and potassium (K)). The extensive soil sampling was carried out from the apple orchards (AO) and potential areas under agricultural land (AL) in Kinnaur region of cold desert, Trans-Himalaya, India. Descriptive statistics was employed for the exploratory analysis of data representing a wide variation (coefficient of variation, CV = 5.70-58.62%). The available N and P, categorized as low (< 280 kg ha-1) to medium (280-560 kg ha-1) and low (4-10 kg ha-1) to high (> 25 kg ha-1), respectively, were the main limiting factors in crop production. The availability of the K was categorized as medium (118-280 kg ha-1) to high (> 280 kg ha-1). The geostatistical analysis was carried out to check the spatial dependency in the dataset. The principal component analysis (PCA) was carried out and the dominant PCs were used in fuzzy c-means clustering for the delineation of management zones (MZs). The management zones highlight the need for area-specific interventions for ameliorating soil degradation and increasing apple productivity. The soil nutrient maps in spatial scale would help to provide precise fertilizer recommendations for sustainable production and environmental conservation.


Asunto(s)
Malus , Suelo , Carbono , Ecosistema , Monitoreo del Ambiente , Nutrientes
4.
Medicina (Kaunas) ; 57(4)2021 Apr 07.
Artículo en Inglés | MEDLINE | ID: mdl-33916978

RESUMEN

Chronic thromboembolic pulmonary hypertension (CTEPH) is a specific type of pulmonary hypertension (PH) and the major component of Group 4 pulmonary hypertension (PH). It is caused by pulmonary vasculature obstruction that leads to a progressive increase in pulmonary vascular resistance and, ultimately, to failure of the right ventricle. Pulmonary thromboendarterectomy (PEA) is the only definitive therapy, so a timely diagnosis and early referral to a specialized PEA center to determine candidacy is prudent for a favorable outcome. Percutaneous balloon pulmonary angioplasty (BPA) has a potential role in patients unsuitable for PEA. Medical therapy with riociguat is the only PH-specific medical therapy currently approved for the treatment of inoperable or persistent CTEPH. This review article aims to revisit CTEPH succinctly with a review of prevailing literature.


Asunto(s)
Angioplastia de Balón , Hipertensión Pulmonar , Embolia Pulmonar , Angioplastia , Enfermedad Crónica , Endarterectomía , Humanos , Hipertensión Pulmonar/complicaciones , Hipertensión Pulmonar/terapia , Embolia Pulmonar/complicaciones
5.
Medicina (Kaunas) ; 56(12)2020 Dec 03.
Artículo en Inglés | MEDLINE | ID: mdl-33287199

RESUMEN

Pulmonary embolism (PE) is a commonly encountered clinical entity in patients with coronavirus disease 2019 (COVID-19). Up to 1/3 of patients have been found to have PE in the setting of COVID-19. Given the novelty of the virus causing this pandemic, it has not been easy to address diagnostic and management issues in PE. Ongoing research and publications of the scientific literature have helped in dealing with COVID-19 lately and this applies to PE as well. In this article, we attempt to succinctly yet comprehensively discuss PE in patients with COVID-19 with a review of the prevailing literature.


Asunto(s)
COVID-19/sangre , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/terapia , Trombofilia/sangre , Anticoagulantes/uso terapéutico , COVID-19/complicaciones , Angiografía por Tomografía Computarizada , Manejo de la Enfermedad , Coagulación Intravascular Diseminada/sangre , Ecocardiografía , Oxigenación por Membrana Extracorpórea , Productos de Degradación de Fibrina-Fibrinógeno/metabolismo , Fibrinógeno/metabolismo , Humanos , Extremidad Inferior/diagnóstico por imagen , Tiempo de Tromboplastina Parcial , Recuento de Plaquetas , Sistemas de Atención de Punto , Tiempo de Protrombina , Embolia Pulmonar/sangre , Embolia Pulmonar/etiología , Terapia Trombolítica , Trombofilia/complicaciones , Ultrasonografía Doppler Dúplex , Trombosis de la Vena/diagnóstico por imagen , Gammagrafía de Ventilacion-Perfusión
6.
J Stroke Cerebrovasc Dis ; 27(9): 2538-2542, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-29857929

RESUMEN

BACKGROUND: To review the procedural safety and postimplantation complications of Watchman device implanted at 2 community hospitals for primary prevention of systemic embolization in patients with nonvalvular atrial fibrillation (NVAF) who were not candidates for long-term oral anticoagulation (OAC). METHODS: This was a retrospective case series of 48 patients carried out in 2 community hospitals in the United States. Patients with NVAF who had a CHADS2 higher than 2 or CHADS2VASc2 (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke or transient ischemic attack [TIA] or thromboembolism, vascular disease, age 65-74 years, and female gender) score of 3 or higher and were not candidates for long-term OAC. These patients were selected for implantation of Watchman device. They were followed up at 45 days, 6 months, 9 months, and 12 months after implantation of Watchman device to assess for complications involving the device and to determine if anticoagulation could be discontinued at the 45 days follow-up. They were monitored for any systemic thromboembolism while off anticoagulation. RESULTS: The success rate of device implantation was 98% (48 of 49). Only a single patient could not get Watchman implantation because of unfavorable left atrial appendage anatomy. Access-related and device implantation-related complications were zero (0%). At 45 days follow-up and end of follow-up duration, the rate of thrombus formation on the Watchman device was 4% (2 of 48). One patient had TIA after warfarin discontinuation. CONCLUSION: With improved procedural technique and well-trained operators, Watchman implantation is feasible in a community hospital also.


Asunto(s)
Apéndice Atrial , Fibrilación Atrial/cirugía , Prótesis e Implantes , Anciano , Anciano de 80 o más Años , Femenino , Estudios de Seguimiento , Hospitales Comunitarios , Humanos , Masculino , Vigilancia de Productos Comercializados , Estudios Retrospectivos , Accidente Cerebrovascular/prevención & control , Resultado del Tratamiento , Estados Unidos
7.
J Minim Access Surg ; 13(4): 318-320, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28782749

RESUMEN

BACKGROUND: The precise steps for the removal of gall bladder from the gall bladder bed are not well standardised. The dissection becomes more difficult near the fundus where the assistant's grasper holding the fundus creates a 'tug of war' like situation. MATERIALS AND METHODS: This is a description of a simple technique that aids in accurate dissection of the gallbladder from liver bed. As the gallbladder dissection approaches fundus and more than two-third of gallbladder is dissected from liver bed, the medial and lateral peritoneal folds of gall bladder are further incised. The assistant is asked to leave the traction from the gallbladder fundus, while the surgeon holds the dissected surface of gall bladder around 2-3 cm away from its attachment with liver and flip it above the liver. Further dissection is carried out using a hook or a dissector till it is disconnected completely from the liver bed. RESULTS: We have employed 'Flip technique' in around 645 consecutive cases of laparoscopic cholecystectomy operated in the past 3 years. Only one case of liver bed bleeding and two cases of injury to gall bladder wall were noted during this part of dissection in this study. Ease of dissection by surgeons was rated as 9.6 on a scale of 1-10. CONCLUSION: Gallbladder 'Flip technique' is a simple and easily reproducible technique employed for dissection of gall bladder from liver bed that reduces complications and makes dissection easier.

8.
Langmuir ; 31(1): 413-23, 2015 Jan 13.
Artículo en Inglés | MEDLINE | ID: mdl-25547202

RESUMEN

Nanostructured zinc sulfide can provide unique photonic, electronic, and catalytic properties that are of interest for applications ranging from bioimaging to photocatalysis. Here we report an easily controllable continuous method to produce porous and hollow ZnS nano- and microspheres. We used poly(ethylene glycol) methyl ether (PEG), polyvinylpyrrolidone (PVP), ethylene oxide/propylene oxide block copolymer (Pluronic F-38), and cetyltrimethylammonium bromide (CTAB) as templates to synthesize ZnS nano- and microspheres with controlled internal morphology in a spray pyrolysis process, starting from an aqueous solution of chemical precursors and templating agents. Spherical particles were produced by droplet-to-particle conversion of droplets. Zinc acetate and thiourea, used here as precursors for ZnS, react in solution to form bis-thiourea zinc acetate (BTZA), which precipitates with the evaporation of solvent. Upon further heating, BTZA decomposes to yield ZnS. During solvent evaporation, PEG and Pluronic precipitate after BTZA, driving formation of a shell of ZnS and a hollow core. In contrast, PVP and CTAB interact strongly with BTZA and ZnS, such that the PVP and ZnS remain intermixed. After evaporation of solvent, the templating agents can be pyrolyzed at high temperature to leave behind porous or hollow ZnS microspheres composed of many much smaller nanocrystals.

9.
Cureus ; 16(7): e65429, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-39184613

RESUMEN

Intravenous injection of pulverized tablet formulations intended for oral use may lead to pulmonary foreign body granulomatosis, a rare and serious condition. This case report details an unusual case of pulmonary micronodular disease resulting from the injection of crushed hydrocodone bitartrate and acetaminophen tablets via a peripherally inserted central catheter (PICC). A 62-year-old female on total parenteral nutrition presented with progressive dyspnea on exertion. A high-resolution CT scan revealed bilateral diffuse pulmonary nodules. Bronchoscopy and lung biopsy confirmed the presence of granulomatous inflammation with foreign-body giant cells, consistent with a foreign-body reaction. A detailed history uncovered that the patient had been administering crushed oral medication through her PICC line for better pain control. This case report adds to the literature by documenting the severe consequences of PICC line misuse and enhancing the understanding of lung granulomatous reactions from foreign materials.

10.
Chemosphere ; 352: 141453, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38364916

RESUMEN

Polyethylene Terephthalate (PET) is a polymer which is considered as one of the major contaminants to the environment. The PET waste materials can be recycled to produce value-added products. PET can be converted to nanoparticles, nanofibers, nanocomposites, and nano coatings. To extend the applications of PET nanomaterials, understanding its commercialization potential is important. In addition, knowledge about the factors affecting recycling of PET based nanomaterials is essential. The presented review is focused on understanding the PET commercialization aspects, keeping in mind market analysis, growth drivers, regulatory affairs, safety considerations, issues associated with scale-up, manufacturing challenges, economic viability, and cost-effectiveness. In addition, the paper elaborates the challenges associated with the use of PET based nanomaterials. These challenges include PET contamination to water, soil, sediments, and human exposure to PET nanomaterials. Moreover, the paper discusses in detail about the factors affecting PET recycling, commercialization, and circular economy with specific emphasis on life cycle assessment (LCA) of PET recycled nanomaterials.


Asunto(s)
Nanocompuestos , Nanopartículas , Humanos , Tereftalatos Polietilenos , Reciclaje , Polímeros
11.
Plant Physiol Biochem ; 207: 108334, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38219424

RESUMEN

The exponentially increasing population and the demand for food is inextricably linked. This has shifted global attention to improving crop plant traits to meet global food demands. Potato (Solanum tuberosum L.) is a major non-grain food crop that is grown all over the world. Currently, some of the major global potato research work focuses on the significance of microRNAs (miRNAs) in potato. miRNAs are a type of non-coding RNAs that regulate the gene expression of their target mRNA genes by cleavage and/or their translational inhibition. This suggests an essential role of miRNAs in a multitude of plant biological processes, including maintenance of genome integrity, plant growth, development and maturation, and initiation of responses to various stress conditions. Therefore, engineering miRNAs to generate stress-resistant varieties of potato may result in high yield and improved nutritional qualities. In this review, we discuss the potato miRNAs specifically known to play an essential role in the various stages of the potato life cycle, conferring stress-resistant characteristics, and modifying gene expression. This review highlights the significance of the miRNA machinery in plants, especially potato, encouraging further research into engineering miRNAs to boost crop yields and tolerance towards stress.


Asunto(s)
MicroARNs , Solanum tuberosum , MicroARNs/genética , MicroARNs/metabolismo , Solanum tuberosum/metabolismo , Plantas/genética , Desarrollo de la Planta , Regulación de la Expresión Génica de las Plantas , Estrés Fisiológico/genética
12.
Brief Funct Genomics ; 2024 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-38679487

RESUMEN

Genetic variability is essential for the development of new crop varieties with economically beneficial traits. The traits can be inherited from wild relatives or induced through mutagenesis. Novel genetic elements can then be identified and new gene functions can be predicted. In this study, forward and reverse genetics approaches were described, in addition to their applications in modern crop improvement programs and functional genomics. By using heritable phenotypes and linked genetic markers, forward genetics searches for genes by using traditional genetic mapping and allele frequency estimation. Despite recent advances in sequencing technology, omics and computation, genetic redundancy remains a major challenge in forward genetics. By analyzing close-related genes, we will be able to dissect their functional redundancy and predict possible traits and gene activity patterns. In addition to these predictions, sophisticated reverse gene editing tools can be used to verify them, including TILLING, targeted insertional mutagenesis, gene silencing, gene targeting and genome editing. By using gene knock-down, knock-up and knock-out strategies, these tools are able to detect genetic changes in cells. In addition, epigenome analysis and editing enable the development of novel traits in existing crop cultivars without affecting their genetic makeup by increasing epiallelic variants. Our understanding of gene functions and molecular dynamics of various biological phenomena has been revised by all of these findings. The study also identifies novel genetic targets in crop species to improve yields and stress tolerances through conventional and non-conventional methods. In this article, genetic techniques and functional genomics are specifically discussed and assessed for their potential in crop improvement.

13.
Open Respir Med J ; 18: e18743064279064, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38660684

RESUMEN

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report is an essential resource for all clinicians who strive to provide optimal care to patients with chronic obstructive lung disease (COPD). The annual report of GOLD makes few revisions and updates besides including data from the preceding year. At an interval, GOLD comes up with a significant modification in its guidelines, which is generally a major overhaul of the pre-existing guidelines. According to the latest 2023 updates, published in November 2022, there have been significant advancements made in the field of COPD. These include the development of more precise definitions for COPD and its exacerbations, the introduction of a new set of parameters to measure exacerbation severity, and updating the COPD assessment tool. Additionally, revisions have been made to the initial and follow-up treatment guidelines. The report also simplifies the treatment algorithm and sheds light on new findings that suggest the use of pharmacological triple therapy can reduce mortality rates. Furthermore, the report includes discussions on inhaler device selection and adherence to COPD medications. These improvements demonstrate a continued effort to enhance COPD treatment and management. Although there are some areas that could benefit from more detailed guidance and explanation, such as the proper utilization of blood eosinophil counts for treatment decisions, and the establishment of treatment protocols post-hospitalization, the latest modifications to the GOLD recommendations will undoubtedly aid healthcare providers in addressing any gaps in patient care. We aim to highlight key changes in the GOLD 2023 report and present a viewpoint about their potential implications in a real-world clinical scenario.

14.
Open Respir Med J ; 18: e18743064288565, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39136034

RESUMEN

Pulmonary hypertension (PH) is an intricate medical issue resulting from increased pressure in the pulmonary artery (PA). The current gold standard for diagnosis involves an invasive procedure known as right heart catheterization. Nevertheless, cardiac magnetic resonance imaging (cMRI) offers a non-invasive and valuable alternative for evaluating the function, structure, and blood flow through the pulmonary artery (PA) in both the left ventricle (LV) and right ventricle (RV). Additionally, cMRI can be a good tool for predicting mortality by assessing various hemodynamic parameters. We perceive that cMRI may be an underutilized tool in the evaluation of PH. More discussions might be needed to highlight its utility in patients with PH. This article aims to discuss the potential role of cMRI in evaluating PH based on the review of recent literature.

15.
Cureus ; 15(3): e36349, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-37082482

RESUMEN

Coronavirus disease 2019 (COVID-19) has inflicted significant mortality and morbidity worldwide since the virus was first detected towards the end of 2019. Though it primarily affects the respiratory system, COVID-19 has been shown to have a multisystem effect. There have been literature on liver injury associated with COVID-19 in general but liver injury specific to certain risk and age groups needs to be looked into. Thus, we aim to discuss the liver injury associated with COVID-19 in various age and risk groups and revisit pathophysiology, biochemical markers and their correlation with outcomes, and current management recommendations.

16.
Cureus ; 15(12): e50621, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-38226123

RESUMEN

Chronic eosinophilic pneumonia (CEP) is not a commonly encountered pulmonary disease that presents with bilateral pulmonary infiltrates accompanied by peripheral and bronchoalveolar lavage (BAL) eosinophilia. Recovery is rapid with systemic steroids but has frequent recurrences. We present a case with the classic presentation of CEP that appears to be related to a weight loss medication called naltrexone-bupropion. This case is unique in that this drug combination does not appear to have an established link to CEP, though literature reveals possible association with its individual components. Understanding the mechanism underlying this link may help to better understand CEP as a disease process.

17.
Cureus ; 15(8): e43716, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-37724234

RESUMEN

Accurate determination of intravascular volume status is challenging in acutely ill patients. Favorable patient outcome is vital to correctly identify intravascular volume depletion and avoid systemic venous congestion. Most of the conventional means of hemodynamic monitoring in the acute healthcare setting are geared toward addressing the cardiac output and maintaining an optimum mean arterial pressure. While assessing and maintaining cardiac output in an acutely ill patient is very important, a venous congestion cascade is often overlooked, which can negatively affect the intraabdominal end organs. The prospect of using point-of-care ultrasound (POCUS) to determine systemic venous congestion could be a potentially handy tool for clinicians. Venous excess ultrasound score (VExUS) has also been utilized by clinicians as a semi-quantitative assessment tool to assess fluid status. This review aims to discuss the potential role of POCUS and VExUS scores in determining systemic venous congestion through a narrative review of recently published literature.

18.
Cureus ; 15(9): e45954, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37900542

RESUMEN

Mitral stenosis (MS) is not a common entity in modern-day medicine, especially in developed countries, as the most common etiology is still rheumatic fever. MS can present mainly with a wide range of cardiac symptoms. However, infrequently, MS can cause extra-cardiac symptoms as well. We present a case report of a patient with severe bioprosthetic mitral valve stenosis with intermittent hemoptysis and cardiogenic shock. We aim to report this case to remind clinicians about this uncommon but significant cause of hemoptysis. This case report also emphasizes the importance of utilizing a team approach while treating patients with severe MS, especially if they have serious complications that could be life-threatening. We also aim to add to the current literature by reporting this case.

19.
Methods Mol Biol ; 2575: 153-179, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36301475

RESUMEN

Plants possess a plethora of important secondary metabolites, which are unique sources of natural pigments, pharmaceutical compounds, food additives, natural pesticides, and other industrial components. The commercial significance of such metabolites/compounds has directed the research toward their production and exploration of methods for enhancement of production. Biotechnological tools are critical in selecting, integrating, multiplying, improving, and analyzing medicinal plants for secondary metabolite production. Out of many techniques that are being explored to enhance secondary metabolite production, "plant cell transfection" is the latest tool to achieve maximum output from the plant source. It is based upon the introduction of foreign DNA into the plant cell relying on physical treatment such as electroporation, cell squeezing, sonoporation, optical transfection nanoparticles, magnetofection, and chemical treatment or biological treatment that depends upon carrier. One of the promising tools that have been exploited is CRISPR-Cas9. Overall, the abovementioned tools focus on the stable transfection of desired gene transcripts. Since the integration and continuous expression of transfected gene of particular trait represents stable transfection of host cell genome, resulting from transfer of required trait to daughter cells ultimately leading to enhanced production of secondary metabolites of interest. This chapter will review a set of biotechnological tools that are candidates for achieving the enhanced bioactive compound production indicated here to be used for drug discovery.


Asunto(s)
Células Vegetales , Plantas Medicinales , Transfección , Plantas Medicinales/metabolismo , Biotecnología , Electroporación
20.
J Med Cases ; 14(6): 191-195, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-37435110

RESUMEN

Spindle cell carcinoma (SpCC), also referred to as sarcomatoid carcinoma, makes up less than 3% of all head and neck squamous cell carcinomas (SCCs). It is an uncommon and unusual biphasic malignant tumor primarily affecting the upper aero-digestive tract. SpCC consists of spindled or pleomorphic tumor cells. Mostly, these tumors are seen in the fifth or sixth decades of life and are strongly associated with smoking and alcohol. We hereby report an infrequently encountered case of SpCC in a patient with xeroderma pigmentosum (XP), who was young, nonsmoker, and did not consume alcohol. The mass arose from the right orbit and involved the entire right face. The postoperative histopathological report showed SpCC. Surgical excision of the mass was performed. We aimed to add to the prevailing literature by reporting this case.

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