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1.
Molecules ; 29(12)2024 Jun 11.
Artículo en Inglés | MEDLINE | ID: mdl-38930831

RESUMEN

In recent years, researchers have often encountered the significance of the aberrant metabolism of tumor cells in the pathogenesis of malignant neoplasms. This phenomenon, known as the Warburg effect, provides a number of advantages in the survival of neoplastic cells, and its application is considered a potential strategy in the search for antitumor agents. With the aim of developing a promising platform for designing antitumor therapeutics, we synthesized a library of conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones. To gain insight into the determinants of the biological activity of the prepared compounds, we showed that the conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones, which are cytotoxic agents, demonstrate selective activity toward a number of tumor cell lines with glycolysis-inhibiting ability. Moreover, the results of molecular and in silico screening allowed us to identify these compounds as potential inhibitors of the pyruvate kinase M2 oncoprotein, which is the rate-determining enzyme of glycolysis. Thus, the results of our work indicate that the synthesized conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones can be considered a promising platform for designing selective cytotoxic agents against the glycolysis process, which opens new possibilities for researchers involved in the search for antitumor therapeutics among compounds containing piperidone platforms.


Asunto(s)
Antineoplásicos , Lactonas , Piperidonas , Sesquiterpenos , Humanos , Sesquiterpenos/farmacología , Sesquiterpenos/química , Lactonas/química , Lactonas/farmacología , Lactonas/síntesis química , Antineoplásicos/farmacología , Antineoplásicos/química , Antineoplásicos/síntesis química , Línea Celular Tumoral , Piperidonas/farmacología , Piperidonas/química , Glucólisis/efectos de los fármacos , Proliferación Celular/efectos de los fármacos , Simulación del Acoplamiento Molecular , Neoplasias/tratamiento farmacológico , Neoplasias/metabolismo , Neoplasias/patología , Ensayos de Selección de Medicamentos Antitumorales
2.
Zh Vopr Neirokhir Im N N Burdenko ; 83(6): 111-119, 2019.
Artículo en Ruso | MEDLINE | ID: mdl-32031174

RESUMEN

Rehabilitation of patients with severe traumatic brain injury (sTBI) is a topical medical and social issue because this pathology is one of the main causes of mortality and disability in the young working age population [1]. The most common sTBI consequences include motor and cognitive impairment as well as depression of consciousness [2, 3]. Despite significant progress in treatment of the consequences of severe traumatic brain injury, there are no treatment and rehabilitation standards for these patients, and the used rehabilitation measures are not always effective. These circumstances substantiate the need for the development of additional methods of neurotherapy. Over the past decade, transcranial electrical and magnetic stimulation (TMS) has been increasingly used as neuromodulatory treatment in clinical practice [4-12]. The accumulated experience has shown that transcranial neurostimulation methods require a more individualized approach in terms of both careful selection of patients and choice of exposure parameters. This review is based on an analysis of the most significant publications and recommendations recognized in the scientific community, as well as on reports of domestic and foreign authors presented at dedicated congresses in comparison with experience of our own research on transcranial stimulation. The paper discusses the main problems of using this method in medical practice of sTMI and their possible solutions.


Asunto(s)
Lesiones Traumáticas del Encéfalo , Rehabilitación Neurológica , Estimulación Transcraneal de Corriente Directa , Estimulación Magnética Transcraneal , Algoritmos , Lesiones Traumáticas del Encéfalo/terapia , Humanos
3.
Artículo en Ruso | MEDLINE | ID: mdl-31251858

RESUMEN

The craniocerebral injury is a global problem of health care and society. The fatal and incapacitating aftermaths developed because of this type of trauma result in significant social and economic losses. To develop effective measures of decreasing these losses epidemiological studies are needed to be implemented considering gender, age, regional and other characteristics. The purpose of study was to analyze regional and epidemiological characteristics of craniocerebral injury in children population of Russia. The study was based on data of state statistic reports in Russia and in its regions in 2003-2004. During analyzed period, dynamics of children morbidity of craniocerebral injury are characterized by its maximal level reached in 2010 (6.3 per 1,000 of children population) and by its decreasing to initial level (5.4% per 1,000 of children population) in 2014. The two-fold increase of percentage of children of the first year of life in mortality of craniocerebral injury was established against the background of stable decrease of craniocerebral injury mortality among children aged from 0 to 17 years. In 2014, every ninth child who died because of head trauma did not survived age of 1 year. In Russia, decreasing of level of hospitalization of children with craniocerebral injury was established. At that, indices of hospitalized morbidity of children of the first year of life increased up to 30%. The actual statistical reporting in Russian Federation provides no full measure evaluation of true levels of mortality, morbidity and hospitalized morbidity. this condition occurs due to limitations of including additional nosological forms in state statistic reporting and to specificity of main disease codification or leading causes of death. The study established significant regional specificity of craniocerebral injury in children that determines necessity of development effective measures considering established epidemiological characteristics.


Asunto(s)
Traumatismos Craneocerebrales , Adolescente , Niño , Preescolar , Traumatismos Craneocerebrales/epidemiología , Traumatismos Craneocerebrales/terapia , Atención a la Salud , Hospitalización , Humanos , Lactante , Recién Nacido , Morbilidad , Federación de Rusia/epidemiología
4.
Urologiia ; (6): 30-33, 2017 Dec.
Artículo en Ruso | MEDLINE | ID: mdl-29376591

RESUMEN

RELEVANCE: Collagen type I and III have a significant role in the development of pelvic organ prolapse (POP) and urinary incontinence in women. The role of the COL3A1 gene polymorphism remains debatable. Some studies and meta-analyzes have found a direct correlation between genetic defects and POP, while other researchers have not confirmed this association. This study aimed to investigate the association of the 1800255 COL3A1 gene polymorphism with the development of POP and urinary incontinence in women. MATERIALS AND METHODS: The study group comprised 52 patients (mean age 64.4 years) with verified POP and stress urinary incontinence. The control group included 21 patients without pelvic floor dysfunction. Patients were comparable in age and had at least one or more risk factors for developing pelvic floor dysfunction. Exclusion criteria for both groups were Marfan and Ehlers-Danlos syndromes and a history of surgery for POP or incontinence (for the control group). In all women, saliva samples were collected to detect polymorphism at the rs1800255 locus of the COL3A1 gene. Genotyping was conducted by Sanger sequencing. RESULTS: In patients with isolated genital prolapse, homozygous polymorphism (AA) had a low sensitivity (0.06) but an extremely high specificity (0.95). Heterozygote (GA) had the sensitivity of 0.35, the specificity of 0.53, and the AUC of 0.44. For urinary incontinence by homozygote (AA), sensitivity was 0.08, specificity 0.96, and by heterozygote (GA) 0.45 and 0.63, respectively. For the combination of pelvic prolapse and urinary incontinence by homozygote (AA), sensitivity was 0.07, specificity 1.0, and heterozygote (GA) 0.41 and 0.62, respectively. CONCLUSION: Given the high specificity of the polymorphism at the rs1800255 locus of the COL3A1 gene, determined by the Sanger sequencing, it can be concluded that there is an association between this polymorphism and urinary incontinence and POP in women.


Asunto(s)
Colágeno Tipo III/genética , Prolapso de Órgano Pélvico/genética , Polimorfismo Genético , Incontinencia Urinaria/genética , Adulto , Anciano , Femenino , Humanos , Persona de Mediana Edad , Prolapso de Órgano Pélvico/patología , Prolapso de Órgano Pélvico/fisiopatología , Incontinencia Urinaria/patología , Incontinencia Urinaria/fisiopatología
5.
Vopr Onkol ; 62(1): 122-32, 2016.
Artículo en Ruso | MEDLINE | ID: mdl-30444590

RESUMEN

Using the technology of DNA chips Infinium HumanMethylation 450 BeadChip it was analyzed quantitative DNA methylation status in 12 paired samples of prostate adenocarcinoma, and morphologically altered tissues. Analysis of differentially methylated regions of the genome showed an association with abnormal status for 21610 and 3852 hypomethylated hyper-methylated CpG sites. Dominance in the cancer genome hypermethylated sites and their predominant localization in the regulatory regions of genes indicate their possible role in the implementation of mechanisms of gene suppression in the pathogenesis of prostate cancer (PCa). For 14 genes studied were characterized array maximum values hypermethylation in promoter region (> 50% CpG sites) in combination with a high level of methylation differences between treatment groups (> 40%). Role of hypermethylation in some of them: AOX1, KLF8, ZNF154, TMEM106A in the pathogenesis of prostate cancer has been showed previously. Hypermethylation of genes ACSS3, TAC1, TUBA4B, ZSCAN12 not previously been shown for prostate cancer, but is characterized by the association with other cancers. In turn, the differences in the levels of methylation in genes GPRASP1, NKX2-6, ARX, CYBA, EPSTI1, RHCG been documented as a result of a number of genome-research oncology, but has not been studied in detail. To assess the diagnostic potential of epigenetic markers of prostate cancer there was carried out unbiased selection of individual CpG sites most reliably discriminate against tumor samples from a group of no tumor samples. In selected diagnostic model based on logistic regression included 9 CpG sites. Validation of the model was carried out on an independent dataset of methylation of 40 paired samples from the prostate cancer project Atlas of Cancer Genome (TCGA) analyzed on the same version of the DNA chip. Summarized rates of diagnostic informativeness of a model (specificity 95%, sensitivity of 97%, the area under the curve of the diagnostic test (ROC) - 0,96), obtained after validation, allow us to consider these CpG Sites as potential markers for molecular diagnosis of prostate cancer.


Asunto(s)
Biomarcadores de Tumor/genética , Metilación de ADN , ADN de Neoplasias/genética , Estudio de Asociación del Genoma Completo , Proteínas de Neoplasias/genética , Análisis de Secuencia por Matrices de Oligonucleótidos/métodos , Neoplasias de la Próstata/genética , Adulto , Biomarcadores de Tumor/metabolismo , Islas de CpG , ADN de Neoplasias/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Proteínas de Neoplasias/metabolismo , Neoplasias de la Próstata/metabolismo
6.
Fiziol Cheloveka ; 42(5): 23-30, 2016 09.
Artículo en Ruso | MEDLINE | ID: mdl-29932546

RESUMEN

The study analyzed ERPs in 37 healthy right handed subjects without neurological and psychiatric disorders. Young age group consisted of 18 persons aged 18 to 27; advanced age group included 19 persons aged 32 to 59. ERPs were recorded by 32 scalp electrodes according to 10-20% system. Two toned addball paradigm including standard and target tones was used for ERP-recording. The sound sequence was given to examinees without any preliminary instruction. Complex psychology testing included Stroop color and word test for the attention and interference assessment, and Wisconsin card sorting test. Significantly larger amplitude of N200 was detected in young persons in comparison to ones of advantage age. Wavelet-analysis revealed stronger wavelet-connections in frontal-central area on the time range of P300 in persons of advanced age vs. younger ones. The correlation of data of psychological tests examining executive functions was detected with latency of P300 in young examinees and with amplitude of P300 in advanced age ones. Obtained data suggests that switching from one activity to another is prevalence in young persons and focusing on a current activity in advanced age persons.


Asunto(s)
Percepción Auditiva , Potenciales Evocados Auditivos , Adolescente , Adulto , Factores de Edad , Atención , Potenciales Evocados , Función Ejecutiva , Humanos , Persona de Mediana Edad , Adulto Joven
7.
Fiziol Cheloveka ; 41(1): 5-16, 2015.
Artículo en Ruso | MEDLINE | ID: mdl-25857172

RESUMEN

This paper analyzes the variation of the functional anatomy of the brain in healthy people performing identical activities on the basis of functional magneticresonance imaging (fMRI). According to the authors, this approach allows you to showcase a variety of individual strategies to achieve the same external (behavioral) result intracerebral different means, and to identify the factors that determine this diversity. Investigated hemodynamic (fMRT) brain reactions at activization of attention to opening of eyes, motor (search of the right and left hand fingers) and speech tests (mental transfer of months or days of the week upside-down) at 21 healthy subjects (21-30 years): 14 men, 7 women. Certain variety of fMRT answers is revealed: 3-4 jet types of hemodynamic changes were allocated for test in group, and the percent of supervision of each type fluctuated from 40 to 10%. Shown marked gender differences responses which specificity is determined by the nature of the functional load. In motor and speech tests, performed with his eyes closed, fMRI response in women is characterized by greater specificity and locality than in men. At motor tests fMRT answers of men are accompanied big, than at women, inclusion in reaction of frontal areas of the cortex, providing realization of regulatory functions. When opening of eyes the women's fMRT responses, on the contrary, become more diffusion, and men's--more local.


Asunto(s)
Movimientos Oculares/fisiología , Ojo , Imagen por Resonancia Magnética , Caracteres Sexuales , Percepción del Habla/fisiología , Percepción Visual/fisiología , Adulto , Femenino , Humanos , Masculino
8.
Artículo en Ruso | MEDLINE | ID: mdl-25710070

RESUMEN

Bioelectrical (EEG) and hemodynamic (fMRI) responses of cerebral reactions to active and passive movements by the right hand were analyzed in 17 right-handed healthy persons. Individual and averaged fMRI and EEG data was analyzed. The main cortex fMRI responses (sensorimotor cortex of the contralateral, left hemisphere) were topographically similar during both active and passive movements. This fact allows us to recommend the usage of the passive movement paradigm for the mapping of the motor areas in patients with movement disorders. Including in reactive process of cerebellum and subcortical structures at passive movements was more variability than active ones. FMRI-reactions at passive movements were characterized more individual variability than during active ones at the expense of diversity of cerebellum and subcortical structures answers. The EEG analysis revealed that at both passive and active movements there is a coherence increase in the high-frequency alpha-ban in left central-frontal area of the left, activated hemisphere. The power-frequency changes of the EEG parameters during active and passive movements were primarily shown in a frequency increase and the desynchronization of the beta-band. Consistency with the topography of the fMRI response was not found.


Asunto(s)
Cerebro/fisiología , Mano/fisiología , Movimiento/fisiología , Corteza Sensoriomotora/fisiología , Adulto , Mapeo Encefálico , Cerebelo/fisiología , Electroencefalografía , Femenino , Lateralidad Funcional/fisiología , Humanos , Imagen por Resonancia Magnética , Masculino
9.
Zh Vopr Neirokhir Im N N Burdenko ; 78(1): 14-25; discussion 25, 2014.
Artículo en Inglés, Ruso | MEDLINE | ID: mdl-24761592

RESUMEN

The aim of studies of patients in long-term posttraumatic unconscious state (PUS) was to outline prognostically significant EEG-markers of consciousness condition and an assessment of its dynamics orientation. We analysed outcomes of dynamic (from days to 16 years after trauma) EEG studies in 196 patients in TBI-caused PUS and different degrees of mental recovery: from chronic unconscious state up to clear consciousness. These results were compared to clinical protocols and data of MRI. It is revealed that dynamic features of EEC pattern (with the analysis of equivalent dipolar sources of separate components) allow to characterize the severity of patient's current state, to reveal the brain structures with the most expressed dysfunction, to define a zone of local cortical damage, and also the general direction of development of a traumatic illness (as though dynamics of a homeostasis of a brain). Frequency characteristics of EEG power spectrum (average frequency--an effective frequency strip) in a background and at reactions find the greatest predictive importance, especially at their assessment in 2-3 months after a trauma. The background interhemispheric EEG coherence (first of all, frontal) as the integrative characteristic of system brain activity, and its change at reactions to external incentives most reflect degree of consciousness oppression, dynamics and potential of its restoration. It was shown the high informational of the researches EEG changes to indifferent and functionally significant signs for an assessment of CNS functionality, and also of PUS pathogenesis.


Asunto(s)
Lesiones Encefálicas/fisiopatología , Estado de Conciencia , Electroencefalografía , Inconsciencia/fisiopatología , Adolescente , Adulto , Anciano , Lesiones Encefálicas/diagnóstico , Estudios de Casos y Controles , Corteza Cerebral/patología , Corteza Cerebral/fisiopatología , Niño , Humanos , Imagen por Resonancia Magnética , Persona de Mediana Edad , Inconsciencia/diagnóstico
10.
Epigenetics Chromatin ; 17(1): 6, 2024 Mar 14.
Artículo en Inglés | MEDLINE | ID: mdl-38481282

RESUMEN

BACKGROUND: Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methylation and a high rate of large genomic rearrangements are often observed in PRAD. RESULTS: To investigate the reasons for such high variance, we integrated DNA methylation, RNA-seq, and copy number alterations datasets from The Cancer Genome Atlas (TCGA), focusing on PRAD, and employed weighted gene co-expression network analysis (WGCNA). Our results show that only single cluster of co-expressed genes is associated with genomic and epigenomic instability. Within this cluster, TP63 and TRIM29 are key transcription regulators and are downregulated in PRAD. We discovered that TP63 regulates the level of enhancer methylation in prostate basal epithelial cells. TRIM29 forms a complex with TP63 and together regulates the expression of genes specific to the prostate basal epithelium. In addition, TRIM29 binds DNA repair proteins and prevents the formation of the TMPRSS2:ERG gene fusion typically observed in PRAD. CONCLUSION: Our study demonstrates that TRIM29 and TP63 are important regulators in maintaining the identity of the basal epithelium under physiological conditions. Furthermore, we uncover the role of TRIM29 in PRAD development.


Asunto(s)
Neoplasias de la Próstata , Masculino , Humanos , Neoplasias de la Próstata/metabolismo , Metilación de ADN , Secuencias Reguladoras de Ácidos Nucleicos , Inestabilidad Cromosómica , Proteínas de Unión al ADN/genética , Proteínas de Unión al ADN/metabolismo , Factores de Transcripción/genética , Factores de Transcripción/metabolismo , Proteínas Supresoras de Tumor/genética
11.
Artículo en Ruso | MEDLINE | ID: mdl-25464765

RESUMEN

We investigated variability of responses to emotionally important auditory stimulation in different groups of TBI (Traumatic Brain Injury) in acute state or recovery. The patients sampling consisted of three different groups: patients in coma or vegetative state, patients with Severe and Moderate TBI in recovery period. Subjects were stimulated with auditory stimuli containing important physiological sounds (coughing, vomiting), emotional sounds (laughing, crying), nature sounds (bird song, barking), unpleasant household sounds (nails scratching the glass), natural sounds (sea, rain, fire) and neutral sounds (white noise). The background encephalographic activity was registered during at least 7 minutes. EEG was recorded while using portable device "Entsefalan". Significant differences of power of the rhythmic activity registered during the presentation of different types of stimuli were analyzed using Mathlab and Statistica 6.0. Results showed that EEG-response to the emotional stimuli differed depending on consciousness level, stimuli type, severity of TBI. Most valuable changes in EEG spectrum power for a patient with TBI were found for unpleasant auditory stimulation. Responsiveness to the pleasant stimulation could be registered in later stages of coming out of coma than to unpleasant stimulation. Alpha-activity is reducing in patients with TBI: the alpha rhythm depression is most evident in the control group, less in group after moderate TBI, and even less in group after severe TBI. Patients in coma or vegetative state didn't show any response in rhythmic power in the frequency of alpha rhythm.


Asunto(s)
Ritmo alfa , Lesiones Encefálicas/fisiopatología , Electroencefalografía , Estimulación Acústica , Adulto , Lesiones Encefálicas/terapia , Emociones/fisiología , Femenino , Humanos , Masculino
12.
Artículo en Ruso | MEDLINE | ID: mdl-24450163

RESUMEN

Bioelectrical (EEG) and hemodynamic (fMRI-response) cerebral reactions to performance and imaginary motor tasks by right or left hand were analyzed in 15 right-handed healthy persons (21-39 years old). During actual movement the main fMRI-response was registered in the area of central gyrus of the hemisphere contralateral to the working hand. Areas of activation were also revealed in the supplemental motor area and the ipsilateral hemisphere of the cerebellum. EEG data showed coherence increase in high frequency alpha- and beta-bands in the activated hemisphere. In imaginary motor tasks the intensity and topography of fMRI-response became the more variable; response was decreased in the motor area and in cerebellum, they increased in the subcortical structures and in the parietal association zones. EEG changes were very variable in this situation also; it was observe an increase of EEG coherence in the right hemisphere for higher frequency of alpha and beta spectral bands. Changes of power spectrum parameters were similar to performance and imaginary motor tasks. Spectrum power and middle frequency of beta band were increased. Topographically these changes did not correspond to activated hemisphere and it was more in the left hemisphere. These changes were reflected nonspecific component of reaction.


Asunto(s)
Cerebelo/fisiología , Electroencefalografía , Imagen por Resonancia Magnética , Movimiento/fisiología , Adulto , Femenino , Mano/fisiología , Voluntarios Sanos , Humanos , Masculino
13.
Artículo en Ruso | MEDLINE | ID: mdl-22567988

RESUMEN

Behavior and brain electrical activity of 79 male Wistar rats (intact and with acute experimental brainstem injury) were studied during the course of therapeutic transcranial electromagnetic stimulation (TEMS) with frequencies 60 and 70 Hz. In intact animals this effect was accompanied by a decrease in voluntary motor activity and increase in synchronization of the brain electrical activity, in particular, in the delta and beta1 frequency ranges. This inhibitory effect was similar to that of sleep. In the early period of acute experimental stem pathology, the TEMS course was accompanied by suppression of EEG signs of adaptive post-operative stress response and could lead to increased severity of the condition of an animal, along with the slowing of postoperative recovery. Cytomorphological evidence was obtained to the importance of vascular factor in the formation of cerebral reactions to TEMS.


Asunto(s)
Lesiones Encefálicas/fisiopatología , Tronco Encefálico/lesiones , Tronco Encefálico/fisiopatología , Terapia por Estimulación Eléctrica , Recuperación de la Función/fisiología , Estimulación Magnética Transcraneal , Núcleo Vestibular Lateral/fisiopatología , Animales , Ritmo beta/fisiología , Encéfalo/fisiopatología , Lesiones Encefálicas/terapia , Ritmo Delta/fisiología , Masculino , Actividad Motora/fisiología , Plasticidad Neuronal/fisiología , Ratas , Ratas Wistar
14.
Artículo en Ruso | MEDLINE | ID: mdl-22690544

RESUMEN

To gain a deeper insight into the relationship between the electrogenesis and oxygenation of the brain, fMRI and EEG reactions to identical functional loads (opening of the eyes and right- and left-hand fingering) were compared in 11 young right-handed healthy subjects with statistical techniques. Changes in power, frequency and coherent EEG parameters obtained by 18-channel monopolar recording were compared with values of + BOLD-fMRI response, calculated for 18 corresponding cortical areas on the basis of application of the "virtual cap" by the original algorithm. In reactive changes of both hemodynamic and bioelectrical parameters, sets of independent factors were identified, which were regarded on the basis of their topography as specific (localized in the cortical representation ofa relevant analyzer) and nonspecific (diffuse and similar under different functional loads). Specific component dominated in the fMRI response, whereas non-specific component was characteristic of the EEG reaction. The similar topography of reactive fMRI and EEG factors under normal conditions, confirmed by the correlation analysis, reflects the multilevel character of the systemic organization of the brain activity, visualized, in particular, in the sagittal projections of the individual fMRI images. Each of the reactive EEG factors included all of the EEG quantitative characteristics. EEG coherence, which dominated among other parameters (with a local increase in the cortical representation of a relevant analyzer and a diffuse decrease in the areas of the influence of the regulatory structures) displayed the highest correlation with hemodynamic responses of the brain.


Asunto(s)
Mapeo Encefálico/métodos , Encéfalo/fisiología , Electroencefalografía/estadística & datos numéricos , Imagen por Resonancia Magnética/estadística & datos numéricos , Adulto , Movimientos Oculares/fisiología , Femenino , Dedos/fisiología , Lateralidad Funcional/fisiología , Hemodinámica/fisiología , Humanos , Masculino , Análisis Multivariante
15.
Fiziol Cheloveka ; 38(4): 11-7, 2012.
Artículo en Ruso | MEDLINE | ID: mdl-23101360

RESUMEN

The going of present pilot study is an analysis of features changes of EEG short pieces registered from 32 sites, at perception of musical melodies healthy examinees depending on logic (cognizance) and emotional (it was pleasant it was not pleasant) melody estimations. For this purpose changes of event-related synchronization/desynchronization, and also wavelet-synchrony of EEG-responses at 31 healthy examinees at the age from 18 till 60 years were compared. It is shown that at a logic estimation of music the melody cognizance is accompanied the event-related desynchronization in the left fronto-parietal-temporal area. At an emotional estimation of a melody the event-related synchronization in left fronto - temporal area for the pleasant melodies, desynchronization in temporal area for not pleasant and desynchronization in occipital area for the melodies which are not causing the emotional response is typical. At the analysis of wavelet-synchrony of EEG characterizing jet changes of interaction of cortical zones, it is revealed that the most distinct topographical distinctions concern type of processing of the heard music: logic (has learned-hasn't learned) or emotional (it was pleasant-it was not pleasant). If at an emotional estimation changes interhemispheric communications between associative cortical zones (central, frontal, temporal), are more expressed at logic - between inter - and intrahemispheric communications of projective zones of the acoustic analyzer (temporal area). It is supposed that the revealed event-related synchronization/desynhronization reflects, most likely, an activation component of an estimation of musical fragments whereas the wavelet-analysis provides guidance on character of processing of musical stimulus.


Asunto(s)
Percepción Auditiva/fisiología , Corteza Cerebral/fisiología , Electroencefalografía , Emociones/fisiología , Música , Adolescente , Adulto , Humanos , Masculino , Persona de Mediana Edad , Análisis de Ondículas
16.
Artículo en Ruso | MEDLINE | ID: mdl-21469334

RESUMEN

Event-related potentials (ERP) are informative indicators of higher nervous activity of healthy people and patients in pathological states. Traditionally, methods of ERP processing include peak-time characteristics, topographical mapping and localization of equivalent dipole sources. At the same time, estimation of ERP synchronization is complicated by a short duration of the process. The wavelet analysis makes it possible to overcome the disadvantages of the traditional Furrier analysis and to calculate characteristics of ERP synchronization, in particular, phase synchronization. A new approach to estimation of the auditory ERP in healthy persons is proposed in the article. The method is based on the analysis of phase wavelet-synchronization of ERP individual components under conditions of differentiation of different degrees of attention concentration in healthy persons.


Asunto(s)
Potenciales Evocados Auditivos , Estimulación Acústica , Adolescente , Atención , Humanos , Valores de Referencia , Análisis de Ondículas , Adulto Joven
17.
Zh Vopr Neirokhir Im N N Burdenko ; 75(3): 19-30; discussion 30, 2011.
Artículo en Ruso | MEDLINE | ID: mdl-22066253

RESUMEN

The authors analyzed correlations of amplitude and latency levels of N100, N200 and P300 components of acoustic evoked potentials (AEP) registered during sonic stimulation and counting of target-oriented stimuli in 22 patients in vegetative state and mutism as an outcome of traumatic brain injury. Results were analyzed with association of electrophysiological findings with data of diffusion-tensor MRI. 55 healthy volunteers were included into control group. It is described that patients in vegetative state with formal recovery to the level of clear consciousness develop all three components of AEP in response to target-oriented tone. The instruction "to counts" leads to their better development. Patients with restoration to minimal level of consciousness produce all components during audition of sounds and only N100 and N200 in response to standard tone after instruction "to count". It is discovered that levels of amplitude have bigger correlation according to Spearman's criterion with outcome in comparison to latency. There changes are more prominent in N100 and N200 components rather in P300. In addition, after instruction "to count sounds" the registered changes between stages of vegetative state and mutism are significant for leads of left hemisphere, and during audition of sounds--for sagittal leads. The study showed correspondence of acquired changes with MRI data. Chronic unconscious state is associated with changes in corpus callosum (degeneration fibers) and corticospinal tracts in the brainstem. The data are discussed in light of hypothesis of the role of morphofunctional disconnections (brainstem-thalamus and interhemispheric) in impairment of attention and in genesis of different forms of posttraumatic unconscious state.


Asunto(s)
Lesiones Encefálicas/fisiopatología , Electroencefalografía , Potenciales Evocados Auditivos , Inconsciencia/fisiopatología , Adolescente , Adulto , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Índices de Gravedad del Trauma
18.
Fiziol Cheloveka ; 36(6): 32-40, 2010.
Artículo en Ruso | MEDLINE | ID: mdl-21254604

RESUMEN

At 8 healthy examinees-volunteers of 22-25 years the functional effects of super-threshold (above 1.2 T) and subthreshold (70-80% of a motor threshold) rTMS of premotor cortexes medial departments were compared. Functional brain activity changes were estimated (before and 1 hour after stimulation) by comparing data including neuropsychological testing, visual and spectral-coherent EEG-analysis, and also haemodynamic parameters. The number of the work's problem included selection of activating orientated stimulation's frequency, and also specification objective EEG--criteria of efficiency rTMS. It is established the effect of EEG-analysis during different frequency photostimulation for a choice of activating rTMS. The received results reveal EEG-coherence as one of the most informative characteristics of cerebral neuro-dynamics under rTMS-influence. Dependence of stimulation's functional effects (activated or brake character) from initial level of the intercentral coherent communications is noted. It is revealed that rTMS of the healthy examinees causes certain changes of functional activity of a brain, distinct from placebo-effects. rTMS-effect dependent on intensity (super--or sub-threshold), and also from features of an initial intercentral rations. More expressed functional changes are observed in the left hemisphere. It is shown big by reactance of the left hemisphere on this influence. In formation of brain responses on rTMS the active role of the vascular factor is shown.


Asunto(s)
Ondas Encefálicas/fisiología , Cerebro/fisiología , Estimulación Magnética Transcraneal/métodos , Adulto , Humanos , Masculino
19.
Fiziol Cheloveka ; 36(5): 66-75, 2010.
Artículo en Ruso | MEDLINE | ID: mdl-21061671

RESUMEN

fMRI (1.5 or 3 T) and EEG studies with estimation of reactive responses on motor task (by right or left hand) were performed in 9 patients with tumors localized in frontal lobe of the brain. Results of this investigation were compared with results of the similar study in 12 healthy persons. It was shown that in cases of the brain pathology disorders of functional specialization and increase of diffuse component of reactivity was observed, fMRI-responses had been characterized the more intact reactions than reactive changes of EEG parameters. This specificity was described in cases of afferent loads in damaged hemisphere. Peculiarity of including different spectral bands in forming of EEG responses on motor tasks and changes of fMRI-answer depend on degree of cerebral decompensation, reflected in the of baseline EEG reorganization and degree of motor defect. Predominantly an increase of EEG coherence in delta-band with the predominance of reaction in the damaged hemisphere in cases of addressing any afferent load was observed in patients with severe cerebral decompensation and reflect dominant character of pathological focus forming. This data indicate on the more including of the deep brain structures in process of reactivity in patients compared with healthy persons and confirmed by fMRI-data.


Asunto(s)
Neoplasias Encefálicas/fisiopatología , Electroencefalografía , Lóbulo Frontal/fisiopatología , Imagen por Resonancia Magnética , Adulto , Anciano , Neoplasias Encefálicas/patología , Femenino , Lóbulo Frontal/patología , Humanos , Masculino , Persona de Mediana Edad
20.
Voen Med Zh ; 331(8): 25-8, 2010 Aug.
Artículo en Ruso | MEDLINE | ID: mdl-21089429

RESUMEN

21 patients with lumbosacral osteochondritis and diskal hernia were treated. Diagnosis was verified with the help of radiological method. The spinal motion segment after the hernia excision was fixed with the help of fixator with the shape memory for the prevention of post-operation instability. Thioctic acid showed the high effectiveness in complex treatment of radiculopathy.


Asunto(s)
Antioxidantes/administración & dosificación , Desplazamiento del Disco Intervertebral/diagnóstico por imagen , Desplazamiento del Disco Intervertebral/terapia , Región Lumbosacra/diagnóstico por imagen , Ácido Tióctico/administración & dosificación , Femenino , Humanos , Masculino , Osteocondritis/diagnóstico por imagen , Osteocondritis/terapia , Radiografía
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