Detalles de la búsqueda
1.
FDA Approval Summary: Daratumumab for Treatment of Multiple Myeloma After One Prior Therapy.
Oncologist;
22(11): 1347-1353, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28904172
2.
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.
Bioorg Med Chem Lett;
27(14): 3101-3106, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28539220
3.
Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.
Bioorg Med Chem Lett;
24(24): 5721-5726, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25453808
4.
Development of a carbon-14 labeling approach to support disposition studies with a pegylated biologic.
Drug Metab Dispos;
40(9): 1677-85, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22627466
5.
Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.
Chem Res Toxicol;
25(3): 556-71, 2012 Mar 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-22295996
6.
FDA Approval Summary: Belantamab Mafodotin for Patients with Relapsed or Refractory Multiple Myeloma.
Clin Cancer Res;
28(21): 4629-4633, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35736811
7.
Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition.
Biopharm Drug Dispos;
32(2): 65-75, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21341276
8.
FDA Approval Summary: Entrectinib for the Treatment of NTRK gene Fusion Solid Tumors.
Clin Cancer Res;
27(4): 928-932, 2021 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32967940
9.
Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.
Acta Pharmacol Sin;
31(9): 1223-40, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20729872
10.
Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.
Pharm Res;
26(10): 2324-31, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19669099
11.
Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters.
Biopharm Drug Dispos;
30(7): 345-55, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19725016
12.
Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.
Cancer Res;
67(20): 9937-44, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17942926
13.
Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism.
Mol Cancer Ther;
7(9): 2609-20, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18790744
14.
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.
ACS Med Chem Lett;
10(3): 306-311, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891131
15.
Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.
Cancer Res;
66(2): 613-21, 2006 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16423986
16.
Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study.
J Chromatogr B Analyt Technol Biomed Life Sci;
852(1-2): 56-61, 2007 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17236826
17.
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.
Toxicol Lett;
168(1): 21-39, 2007 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-17127020
18.
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.
Mol Cancer Ther;
5(8): 1918-26, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16928811
19.
Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin.
Mol Cancer Ther;
5(1): 39-51, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16432161
20.
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.
Oncogene;
24(28): 4486-95, 2005 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-15856023