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1.
Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists.
Bioorg Med Chem Lett;
52: 128384, 2021 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34587541
2.
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives.
Bioorg Med Chem Lett;
30(24): 127636, 2020 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33132115
3.
Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats.
J Pharmacol Exp Ther;
369(1): 78-87, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30674560
4.
Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization.
Bioorg Med Chem Lett;
29(9): 1143-1147, 2019 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30833109
5.
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds.
Bioorg Med Chem Lett;
29(5): 688-693, 2019 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30728111
6.
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening.
Bioorg Med Chem Lett;
28(13): 2338-2342, 2018 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29805055
7.
Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach.
Bioorg Med Chem Lett;
27(17): 4194-4198, 2017 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28754363
8.
Suppression of the acute upregulation of phosphorylated-extracellular regulated kinase in ventral tegmental area by a µ-opioid receptor agonist is related to resistance to rewarding effects in a mouse model of bone cancer.
J Pharmacol Sci;
133(1): 9-17, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28034513
9.
Effect of the norepinephrine transporter (NET) inhibition on µ-opioid receptor (MOR)-induced anti-nociception in a bone cancer pain model.
J Pharmacol Sci;
125(3): 264-73, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24965165
10.
[11C]PK11195 PET imaging of spinal glial activation after nerve injury in rats.
Neuroimage;
79: 121-8, 2013 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23611861
11.
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs.
Bioorg Med Chem Lett;
18(24): 6444-7, 2008 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18977140
12.
Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α2A-adrenergic receptors in rats.
Behav Brain Res;
345: 21-29, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29476896
13.
Ibudilast produces anti-allodynic effects at the persistent phase of peripheral or central neuropathic pain in rats: Different inhibitory mechanism on spinal microglia from minocycline and propentofylline.
Eur J Pharmacol;
833: 263-274, 2018 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29886243
14.
Injury-specific functional alteration of N-type voltage-gated calcium channels in synaptic transmission of primary afferent C-fibers in the rat spinal superficial dorsal horn.
Eur J Pharmacol;
772: 11-21, 2016 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26708163
15.
Effect of estrogen on morphine- and oxycodone-induced antinociception in a female femur bone cancer pain model.
Eur J Pharmacol;
773: 1-12, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26802873
16.
Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors.
Neurosci Lett;
615: 78-82, 2016 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-26806036
17.
[Pharmacological profiles of benzodiazepinergic hypnotics and correlations with receptor subtypes].
Nihon Shinkei Seishin Yakurigaku Zasshi;
25(3): 143-51, 2005 Jun.
Artículo
en Japonés
| MEDLINE | ID: mdl-16045197
18.
Role of voltage-dependent calcium channel subtypes in spinal long-term potentiation of C-fiber-evoked field potentials.
Pain;
152(3): 623-631, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21211907
19.
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.
Bioorg Med Chem Lett;
17(14): 3925-9, 2007 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17531479
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