Detalles de la búsqueda
1.
Design and development of benzyl piperazine linked 5-phenyl-1,2,4-triazole-3-thione conjugates as potential agents to combat Alzheimer's disease.
Bioorg Chem;
139: 106749, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37517157
2.
Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease.
Bioorg Chem;
111: 104922, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33945941
3.
Computational exploration and experimental validation to identify a dual inhibitor of cholinesterase and amyloid-beta for the treatment of Alzheimer's disease.
J Comput Aided Mol Des;
34(9): 983-1002, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32488355
4.
Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease.
Bioorg Med Chem;
28(22): 115721, 2020 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33007563
5.
Design, synthesis, and biological evaluation of ferulic acid based 1,3,4-oxadiazole hybrids as multifunctional therapeutics for the treatment of Alzheimer's disease.
Bioorg Chem;
95: 103506, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31887472
6.
Design, synthesis, and evaluation of novel N-(4-phenoxybenzyl)aniline derivatives targeting acetylcholinesterase, ß-amyloid aggregation and oxidative stress to treat Alzheimer's disease.
Bioorg Med Chem;
27(16): 3650-3662, 2019 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31288978
7.
Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions.
Bioorg Chem;
89: 103025, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31176239
8.
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.
Bioorg Chem;
69: 102-120, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27750057
9.
Identifying inflammation-related targets of natural lactones using network pharmacology, molecular modeling and in vitro approaches.
J Biomol Struct Dyn;
: 1-16, 2024 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38334283
10.
Hydroxamic acid derivatives as selective HDAC3 inhibitors: computer-aided drug design strategies.
J Biomol Struct Dyn;
42(1): 362-383, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-36995068
11.
Design, Synthesis, and Biological Investigation of Quinazoline Derivatives as Multitargeting Therapeutics in Alzheimer's Disease Therapy.
ACS Chem Neurosci;
15(4): 745-771, 2024 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38327209
12.
Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy.
Eur J Med Chem;
271: 116409, 2024 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38663285
13.
Lead optimization based design, synthesis, and pharmacological evaluation of quinazoline derivatives as multi-targeting agents for Alzheimer's disease treatment.
Eur J Med Chem;
271: 116450, 2024 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38701714
14.
Synthesis, cytotoxic evaluation, docking and in silico pharmacokinetic prediction of 4-arylideneamino/cycloalkylidineamino 1, 2-naphthoquinone thiosemicarbazones.
J Enzyme Inhib Med Chem;
28(6): 1192-8, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22978426
15.
In silico and in vitro evaluation of extract derived from Dunaliella salina, a halotolerant microalga for its antifungal and antibacterial activity.
J Biomol Struct Dyn;
41(15): 7069-7083, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36017823
16.
Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat Alzheimer's Disease.
ACS Omega;
8(10): 9394-9414, 2023 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36936338
17.
Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for Alzheimer's Disease Therapy.
ACS Chem Neurosci;
14(11): 2217-2242, 2023 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37216500
18.
Cholinesterase as a Target for Drug Development in Alzheimer's Disease.
Methods Mol Biol;
2089: 257-286, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-31773661
19.
Solid-phase synthesis of oligosaccharide drugs: a review.
Mini Rev Med Chem;
9(2): 169-85, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19200022
20.
Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease.
ACS Chem Neurosci;
10(10): 4361-4384, 2019 10 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-31491074