Off-label use of a vena caval filter in the SVC in an adolescent with upper deep vein thrombosis.

Vena caval filters remain as a useful tool in patients with deep vein thrombosis and contraindications to anticoagulation. Although they are rarely used in paediatric patients, they have been shown to be safe and effective when used in the inferior vena cava.In this case report, we describe the off-label use of a retrievable vena caval filter in the superior vena cava in an adolescent with acute lymphoblastic leukaemia with extensive thrombosis of the right upper neck veins as a means to reduce the risk of pulmonary embolism.

Key dimensions of cities' engagement in the transition to climate neutrality.

Urbanization and the concentration of energy-consuming economic activities make cities responsible for more than 70% of global greenhouse gas emissions. At the same time, cities are becoming increasingly vulnerable to climate change impacts. The European Cities Mission launched a call in September 2021 to set out on a path towards "100 climate-neutral and smart cities by 2030". A very large and diverse sample of 344 candidate cities in 35 countries (a subset of the 362 considered eligible to participate in the Cities Mission) was used to conduct this timely research aimed at identifying the main dimensions on which cities are working to achieve a smart and sustainable transition. The research focused on five main dimensions: local climate planning, climate emergency declarations, participation in networks, international projects and competitions. Results show that only 20 (5.8%) cities have no experience in any of them, while there are 18 (5.2%) cities that have in their background activities that fall under all dimensions. Moreover, networking is the most important dimension, among the five analysed, for cities applying for this Mission, involving 309 cities (approximately 90% of the sample). This is followed by local climate planning, involving 275 cities (80%) and city participation in international projects, involving 152 cities (44%). Cities that have declared a climate emergency are less than a fifth of the sample and are very unevenly distributed in only 37.1% of the countries represented (interestingly, all the UK cities in the sample). Similarly, only 49 cities (14.2%) have received international awards. The results provide insights into the main efforts currently being made by cities to engage in the transition to climate neutrality and may be useful to practitioners, scholars and policy-makers at all levels to improve their knowledge of the steps they need to take to support this process and amplify its scope.

Climate mitigation in the Mediterranean Europe: An assessment of regional and city-level plans.

In Europe, regions in the Mediterranean area share common characteristics in terms of high sensitivity to climate change impacts. Does this translate into specificities regarding climate action that could arise from these Mediterranean characteristics? This paper sheds light on regional and local climate mitigation actions of the Mediterranean Europe, focusing on the plans to reduce greenhouse gases emissions in a representative sample of 51 regions and 73 cities across 9 Mediterranean countries (Croatia, Cyprus, France, Greece, Italy, Malta, Portugal, Slovenia, Spain). The study investigates: (i) the availability of local and regional mitigation plans, (ii) their goals in term of greenhouse gas emissions reduction targets on the short and medium-long term, and (iii) the impact of transnational climate networks on such local and regional climate mitigation planning. Results of this study indicate an uneven and fragmented planning, that shows a Mediterranean West-East divide, and a link with population size. However, overall, both regional and city action seem insufficiently ambitious with regards to meeting the Paris Agreement, at least at city level. While national frameworks are currently weak in influencing regional and local actions, transnational networks seem to be engaging factors for commitment (at city level) and ambitiousness (at regional level). The uneven and fragmented progress revealed by this study, does not align with the characteristics shared by investigated regions and cities in terms of environmental, socio-political, climatic and economic conditions. The results support the call of a common green deal at the Mediterranean level to further address specific Mediterranean challenges and related needs. This will allow to capitalise on available resources, generate local-specific knowledge, build capacities, and support Mediterranean regions and cities in preparing the next generation of more ambitious mitigation plans.

Influence of computers in students' academic achievement.

With fast-growing technology, schools have to adapt and use technology constantly as a tool to grow. This study aims to understand the influence of computer factors on students' academic achievement. We propose a model on the influence of computer attitudes, computer learning environments, computer learning motivations, computer confidence, computer use, computer self-efficacy, loneliness, mothers' education, parents' marital status and family size on academic achievement (AA). To validate the conceptual model, 286 students aged 16-18 years old answered an online questionnaire. The most important drivers that positively affect AA are computer use, employment motivations, and mothers' education. While enjoyment attitudes, school environment, interest motivations, and loneliness influence AA negatively. Also, family size and computer self-efficacy work as moderators, and computer use works as a mediator between computer learning environments and academic achievement.

Expression of the chick vascular endothelial growth factor D gene during limb development.

Vascular endothelial growth factor D (VEGF-D) is a member of the VEGF/PDGF superfamily that has been implicated in angiogenesis and lymphangiogenesis. We have isolated a chick cDNA that shows homology with VEGF-D (also known as FIGF, c-fos-induced growth factor) of other species. Here, we describe the expression pattern of cVegf-D in chick embryos. In the limb buds, cVegf-D shows a dynamic expression pattern that is restricted to the mesenchyme of the posterior region. cVegf-D expression is also detected in the ectoderm and mesenchyme of the head region, somites, notochord and pharyngeal arches. We also report on the capability of Sonic hedgehog and retinoic acid to regulate cVegf-D expression.