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1.

Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism.

Sikorska, Justyna; Hou, Yan; Chiurazzi, Paul; Siu, Tony; Baltus, Gretchen A; Sheth, Payal; McLaren, David G; Truong, Quang; Parish, Craig A; Wyss, Daniel F.

Nucleic Acids Res; 51(17): 9356-9368, 2023 09 22.

Artículo en Inglés | MEDLINE | ID: mdl-37486777

2.

Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors.

Simov, Vladimir; Deshmukh, Sujal V; Dinsmore, Christopher J; Elwood, Fiona; Fernandez, Rafael B; Garcia, Yudith; Gibeau, Craig; Gunaydin, Hakan; Jung, Joon; Katz, Jason D; Kraybill, Brian; Lapointe, Blair; Patel, Sangita B; Siu, Tony; Su, Hua; Young, Jonathan R.

Bioorg Med Chem Lett; 26(7): 1803-8, 2016 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-26927423

3.

The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.

Siu, Tony; Kumarasinghe, Sathyajith E; Altman, Michael D; Katcher, Matthew; Northrup, Alan; White, Catherine; Rosenstein, Craig; Mathur, Anjili; Xu, Lin; Chan, Grace; Bachman, Eric; Bouthillette, Melaney; Dinsmore, Christopher J; Marshall, C Gary; Young, Jonathan R.

Bioorg Med Chem Lett; 24(6): 1466-71, 2014 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-24582987

4.

Efficacy and safety of modified Xiao-Feng Powder in the treatment of chronic urticaria: protocol of a randomized double-blind placebo-controlled study.

Hung, Hing Yu; Song, Tianhe; Loo, Steven King Fan; Chan, Kam Leung; Ching, Jessica Yuet Ling; Sum, Chi Him; Lo, Louis Cho Wing; Chia, Sarah Chon Pin; Ho, Ray Tin Muk; Cheong, Pui Kuan; Siu, Tony Hon Chung; Leung, Ka Chun; Lin, Zhi-Xiu.

Chin Med; 17(1): 87, 2022 Jul 22.

Artículo en Inglés | MEDLINE | ID: mdl-35869554

5.

The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial.

Cheong, Pui Kuan; Ho, Tin Muk; Chan, Kam Leung; Lo, Cho Wing; Leung, Sin Bond; Hon, Kam Lun; Leung, Ka Chun; Siu, Tony Hon Chung; Song, Tian-He; Zhang, Hongwei; Ching, Jessica Yuet Ling; Chow, Tak Yee; Sum, Chi Him; Chia, Chon Pin; Lin, Zhi-Xiu.

Front Pharmacol; 13: 1058176, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-36588672

6.

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.

Chang, Wonsuk; Altman, Michael D; Lesburg, Charles A; Perera, Samanthi A; Piesvaux, Jennifer A; Schroeder, Gottfried K; Wyss, Daniel F; Cemerski, Saso; Chen, Yiping; DiNunzio, Edward; Haidle, Andrew M; Ho, Thu; Kariv, Ilona; Knemeyer, Ian; Kopinja, Johnny E; Lacey, Brian M; Laskey, Jason; Lim, Jongwon; Long, Brian J; Ma, Yanhong; Maddess, Matthew L; Pan, Bo-Sheng; Presland, Jeremy P; Spooner, Edward; Steinhuebel, Dietrich; Truong, Quang; Zhang, Zhibo; Fu, Jianmin; Addona, George H; Northrup, Alan B; Parmee, Emma; Tata, James R; Bennett, David Jonathan; Cumming, Jared N; Siu, Tony; Trotter, B Wesley.

J Med Chem; 65(7): 5675-5689, 2022 04 14.

Artículo en Inglés | MEDLINE | ID: mdl-35332774

7.

The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead.

Siu, Tony; Kozina, Ekaterina S; Jung, Joon; Rosenstein, Craig; Mathur, Anjili; Altman, Michael D; Chan, Grace; Xu, Lin; Bachman, Eric; Mo, Jan-Rung; Bouthillette, Melaney; Rush, Thomas; Dinsmore, Christopher J; Marshall, C Gary; Young, Jonathan R.

Bioorg Med Chem Lett; 20(24): 7421-5, 2010 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-21044843

8.

Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.

Li, Yiwei; Liang, Jun; Siu, Tony; Hu, Essa; Rossi, Michael A; Barnett, Stanley F; Defeo-Jones, Deborah; Jones, Raymond E; Robinson, Ronald G; Leander, Karen; Huber, Hans E; Mittal, Sachin; Cosford, Nicholas; Prasit, Peppi.

Bioorg Med Chem Lett; 19(3): 834-6, 2009 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-19097777

9.

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.

Siu, Tony; Altman, Michael D; Baltus, Gretchen A; Childers, Matthew; Ellis, J Michael; Gunaydin, Hakan; Hatch, Harold; Ho, Thu; Jewell, James; Lacey, Brian M; Lesburg, Charles A; Pan, Bo-Sheng; Sauvagnat, Berengere; Schroeder, Gottfried K; Xu, Serena.

ACS Med Chem Lett; 10(1): 92-97, 2019 Jan 10.

Artículo en Inglés | MEDLINE | ID: mdl-30655953

10.

Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors.

Siu, Tony; Liang, Jun; Arruda, Jeannie; Li, Yiwei; Jones, Raymond E; Defeo-Jones, Deborah; Barnett, Stanley F; Robinson, Ronald G.

Bioorg Med Chem Lett; 18(14): 4186-90, 2008 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-18539456

11.

The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity.

Siu, Tony; Li, Yiwei; Nagasawa, Johnny; Liang, Jun; Tehrani, Lida; Chua, Peter; Jones, Raymond E; Defeo-Jones, Deborah; Barnett, Stanley F; Robinson, Ronald G.

Bioorg Med Chem Lett; 18(14): 4191-4, 2008 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-18550373

12.

The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.

Siu, Tony; Brubaker, Jason; Fuller, Peter; Torres, Luis; Zeng, Hongbo; Close, Joshua; Mampreian, Dawn M; Shi, Feng; Liu, Duan; Fradera, Xavier; Johnson, Kevin; Bays, Nathan; Kadic, Elma; He, Fang; Goldenblatt, Peter; Shaffer, Lynsey; Patel, Sangita B; Lesburg, Charles A; Alpert, Carla; Dorosh, Lauren; Deshmukh, Sujal V; Yu, Hongshi; Klappenbach, Joel; Elwood, Fiona; Dinsmore, Christopher J; Fernandez, Rafael; Moy, Lily; Young, Jonathan R.

J Med Chem; 60(23): 9676-9690, 2017 12 14.

Artículo en Inglés | MEDLINE | ID: mdl-29156136

13.

Studies directed toward the total synthesis of lactonamycin: control of the sense of cycloaddition of a quinone through directed intramolecular catalysis.

Cox, Christopher D; Siu, Tony; Danishefsky, Samuel J.

Angew Chem Int Ed Engl; 42(45): 5625-9, 2003 Nov 24.

Artículo en Inglés | MEDLINE | ID: mdl-14639734

14.

Total synthesis of lactonamycinone.

Siu, Tony; Cox, Christopher D; Danishefsky, Samuel J.

Angew Chem Int Ed Engl; 42(45): 5629-34, 2003 Nov 24.

Artículo en Inglés | MEDLINE | ID: mdl-14639735

15.

The Total Synthesis of Heliquinomycinone This work was supported by the National Institutes of Health (Grant numbers: AI 16943 and HL25848). The authors thank Dr. Makoto Chino of Nippon Kayaku Co., Ltd. for kindly providing a sample of heliquinomycin, and Yashuiro Itagaki of Columbia University for high-resolution mass spectral analyses.

Siu, Tony; Qin, Donghui; Danishefsky, Samuel J..

Angew Chem Int Ed Engl; 40(24): 4713-4716, 2001 Dec 17.

Artículo en Inglés | MEDLINE | ID: mdl-12404392

16.

Studies in the Total Synthesis of Heliquinomycinone: Proof of Concept and Assembly of a Fully Mature Spirocyclization Precursor This work was supported by the National Institutes of Health (Grant numbers: AI 16943 and HL25848). A Postdoctoral Fellowship is gratefully acknowledged by R.X.R. (NIH, Grant Number IF32EY06750-0181). The authors thank Dr. Daniel Chen for important initial experiments, Dr. Brian Bridgewater and Prof. Ged Parkin of Columbia University for X-ray crystal structure analysis of 11 a, and Yashuiro Itagaki for high-resolution mass spectral analyses.

Qin, Donghui; Ren, Rex X.; Siu, Tony; Zheng, Changsheng; Danishefsky, Samuel J..

Angew Chem Int Ed Engl; 40(24): 4709-4713, 2001 Dec 17.

Artículo en Inglés | MEDLINE | ID: mdl-12404391

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