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1.
Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.
Bioorg Med Chem Lett;
23(11): 3443-7, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23597790
2.
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
Bioorg Med Chem Lett;
23(11): 3438-42, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23582272
3.
Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer.
J Med Chem;
64(18): 13410-13428, 2021 09 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34499493
4.
Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.
J Med Chem;
46(2): 210-3, 2003 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-12519059
5.
Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease.
J Med Chem;
45(10): 2016-23, 2002 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-11985469
6.
Synthesis, Equilibration, and Coupling of 4-Lithio-1,3-dioxanes: Synthons for syn- and anti-1,3-Diols.
J Org Chem;
64(18): 6849-6860, 1999 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-11674695
7.
Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates.
Bioorg Med Chem Lett;
15(11): 2829-33, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911263
8.
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.
Bioorg Med Chem Lett;
14(10): 2433-7, 2004 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15109627
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