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Bioorg Med Chem Lett
; 19(4): 1071-4, 2009 Feb 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19171483
RESUMEN
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.