Detalles de la búsqueda
1.
N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.
Nature;
625(7993): 189-194, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38057663
2.
Evaluating data integrity in ribosome footprinting datasets through modelled polysome profiles.
Nucleic Acids Res;
50(19): e112, 2022 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35979952
3.
Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc-fusion protein produced in CHO cells.
Biotechnol Bioeng;
119(12): 3408-3420, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36082414
4.
Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells.
Biotechnol Bioeng;
118(7): 2422-2434, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33694218
5.
Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis.
Metab Eng;
59: 98-105, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32061967
6.
Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production.
Metab Eng;
57: 203-216, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31805379
7.
Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.
RNA;
22(4): 623-35, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26857222
8.
The effect of formulation variables on protein stability and integrity of a model IgG4 monoclonal antibody and translation to formulation of a model ScFv.
Biotechnol Lett;
40(1): 33-46, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28939995
9.
Erratum for "Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells" (Vol. 118, Issue 7, pp. 2422-2434).
Biotechnol Bioeng;
119(2): 667-669, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34873686
10.
mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells.
Biochem J;
473(24): 4651-4664, 2016 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27760840
11.
Investigations into, and development of, a lyophilized and formulated recombinant human factor IX produced from CHO cells.
Biotechnol Lett;
39(8): 1109-1120, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28484912
12.
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Biochem J;
465(2): 213-25, 2015 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25329545
13.
Biological insights into the expression of translation initiation factors from recombinant CHOK1SV cell lines and their relationship to enhanced productivity.
Biochem J;
472(3): 261-73, 2015 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26420881
14.
Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.
Biochem J;
465(2): 227-38, 2015 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25353634
15.
Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model system.
Biotechnol Lett;
38(4): 589-96, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26699895
16.
The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.
Biotechnol Bioeng;
112(9): 1727-37, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25998019
17.
The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.
Biochem J;
458(2): 213-24, 2014 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24320561
18.
Corrigendum: Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs.
RNA;
23(12): 1961, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29146689
19.
Control and regulation of mRNA translation.
Biochem Soc Trans;
42(1): 151-4, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24450643
20.
Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.
J Biol Chem;
287(29): 24525-33, 2012 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22610095