RESUMEN
The positive identification of crystals of calcium oxalate occurring in brain and kidney after xylitol administration is described. Biochemical, histochemical, conventional light and electron microscopical methods, including selected area electron diffraction, were used to characterize the crystals.
Asunto(s)
Química Encefálica , Riñón/análisis , Xilitol/efectos adversos , Bicarbonatos/sangre , Encéfalo/efectos de los fármacos , Calcio/análisis , Cromatografía de Gases , Cromatografía en Capa Delgada , Creatinina/sangre , Cristalografía , Electrones , Histocitoquímica , Humanos , Riñón/efectos de los fármacos , Túbulos Renales/análisis , Túbulos Renales/patología , Masculino , Microscopía Electrónica , Persona de Mediana Edad , Oxalatos/análisis , Diálisis RenalRESUMEN
C13H8N2O2, Mr = 224.2, monoclinic, Cc, a = 3.955 (1), b = 19.278 (4), c = 13.468 (1) A, beta = 98.90 (2) degrees, V = 1015 (2) A3, Z = 4, D chi = 1.468 Mg m-3, lambda (Mo K alpha) = 0.7107 A, mu = 0.061 mm-1, F(000) = 464, T = 293 (2) K, R = 0.047 for 571 observed reflections. The crystal-structure determination of the title compound, a phenazine antibiotic from Pseudomonas fluorescens 2-79 (NRRL B-15132), confirms its structure as phenazine-1-carboxylic acid. The molecular packing is described by discrete stacks of molecules parallel to the a axis with the distance between the essentially planar molecules being ca 3.96 A; there are no significant intermolecular contacts in the lattice.