RESUMEN
BACKGROUND: Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with prematurity and infants with BPD suffer from increased incidence of respiratory infections, asthma, other forms of chronic lung illness, and death (Day and Ryan, Pediatr Res 81: 210-213, 2017; Isayama et la., JAMA Pediatr 171:271-279, 2017). BPD is now understood as a longitudinal disease process influenced by the intrauterine environment during gestation and modulated by gene-environment interactions throughout the neonatal and early childhood periods. Despite of this concept, there remains a paucity of multidisciplinary team-based approaches dedicated to the comprehensive study of this complex disease. METHODS: The Discovery BPD (D-BPD) Program involves a cohort of infants < 1,250 g at birth prospectively followed until 6 years of age. The program integrates analysis of detailed clinical data by machine learning, genetic susceptibility and molecular translation studies. DISCUSSION: The current gap in understanding BPD as a complex multi-trait spectrum of different disease endotypes will be addressed by a bedside-to-bench and bench-to-bedside approach in the D-BPD program. The D-BPD will provide enhanced understanding of mechanisms, evolution and consequences of lung diseases in preterm infants. The D-BPD program represents a unique opportunity to combine the expertise of biologists, neonatologists, pulmonologists, geneticists and biostatisticians to examine the disease process from multiple perspectives with a singular goal of improving outcomes of premature infants. TRIAL REGISTRATION: Does not apply for this study.
Asunto(s)
Displasia Broncopulmonar/epidemiología , Enfermedades del Prematuro/epidemiología , Recién Nacido de muy Bajo Peso , Estudios Multicéntricos como Asunto/métodos , Animales , Displasia Broncopulmonar/complicaciones , Displasia Broncopulmonar/genética , Enfermedad Crónica , Progresión de la Enfermedad , Exposición a Riesgos Ambientales , Femenino , Estudios de Seguimiento , Estudios de Asociación Genética , Predisposición Genética a la Enfermedad , Edad Gestacional , Humanos , Recién Nacido , Recien Nacido Prematuro , Enfermedades del Prematuro/genética , Unidades de Cuidado Intensivo Neonatal , Investigación Interdisciplinaria , Colaboración Intersectorial , Enfermedades Pulmonares/etiología , Aprendizaje Automático , Masculino , Ratones , Padres , Estudios Prospectivos , Pruebas de Función Respiratoria , Investigación Biomédica TraslacionalRESUMEN
Cardiopulmonary resuscitation (CPR) courses meet all the definitions of an educational activity for prevention of cardiac arrest death by risk patients' parents and/or the general population. The aim is to improve patients' home care and turn parents confident before their children are discharged from hospital, mainly from intensive care units. Currently these courses are part of discharge protocols in many neonatologist services although there are offers that exceed this target, and extend to other areas such as education and caregivers. Locally the experience of neonatal CPR at the Sociedad Argentina de Pediatría stands out in connection with delivering courses to high risk patients' parents as well as designing and spreading learning material.
Asunto(s)
Reanimación Cardiopulmonar/educación , Padres , Humanos , Lactante , Recién NacidoRESUMEN
Los cursos de reanimación cardiopulmonar (RCP), cumplen todas las definiciones de una actividad educativa dirigida hacia la prevención, por parte de los padres, de la muerte por paro cardiorrespiratorio de pacientes de riesgo y/o población general. Su finalidad es principalmente la de mejorar el cuidado hogareño de los pacientes y brindar confianza antes del alta de los sectores de internación, sobre todo de cuidados intensivos. En la actualidad, forman parte del protocolo de alta de muchos servicios de neonatología, aunque hay propuestas que superan este objetivo y se extienden a otras áreas, tales como los distintos ámbitos educativos y cuidadores. A nivel local, se destaca la experiencia del grupo de RCP neonatal de la Sociedad Argentina de Pediatría en sus funciones de dictado regular de cursos a grupos familiares de pacientes de alto riesgo, así como también en la creación y difusión de contenidos.
Cardiopulmonary resuscitation (CPR) courses meet all the definitions of an educational activity for prevention of cardiac arrest death by risk patients' parents and/or the general population. The aim is to improve patients Ì home care and turn parents confident before their children are discharged from hospital, mainly from intensive care units. Currently these courses are part of discharge protocols in many neonatologist services although there are offers that exceed this target, and extend to other areas such as education and caregivers. Locally the experience of neonatal CPR at the Sociedad Argentina de Pediatría stands out in connection with delivering courses to high risk patients Ì parents as well as designing and spreading learning material