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1.

Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose.

Clark, Alex E; Zhu, Zhe; Krach, Florian; Rich, Jeremy N; Yeo, Gene W; Spector, Deborah H.

J Virol; 95(5)2021 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-33328307

2.

Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms.

Clark, Alex E; Sabalza, Maite; Gordts, Philip L S M; Spector, Deborah H.

J Virol; 92(6)2018 03 15.

Artículo en Inglés | MEDLINE | ID: mdl-29237845

3.

Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types.

Belzile, Jean-Philippe; Sabalza, Maite; Craig, Megan; Clark, Alex E; Morello, Christopher S; Spector, Deborah H.

J Virol; 90(3): 1259-77, 2016 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-26559848

4.

Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5.

Clark, Alex E; Spector, Deborah H.

J Virol; 89(13): 6928-39, 2015 07.

Artículo en Inglés | MEDLINE | ID: mdl-25903336

5.

Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.

Belzile, Jean-Philippe; Stark, Thomas J; Yeo, Gene W; Spector, Deborah H.

J Virol; 88(8): 4021-39, 2014 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-24453373

6.

Human cytomegalovirus riding the cell cycle.

Spector, Deborah H.

Med Microbiol Immunol; 204(3): 409-19, 2015 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-25776080

7.

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata, Norihito; Carlin, Aaron F; Spann, Nathanael J; Saijo, Kaoru; Morello, Christopher S; McDonald, Jeffrey G; Romanoski, Casey E; Maurya, Mano R; Kaikkonen, Minna U; Lam, Michael T; Crotti, Andrea; Reichart, Donna; Fox, Jesse N; Quehenberger, Oswald; Raetz, Christian R H; Sullards, M Cameron; Murphy, Robert C; Merrill, Alfred H; Brown, H Alex; Dennis, Edward A; Fahy, Eoin; Subramaniam, Shankar; Cavener, Douglas R; Spector, Deborah H; Russell, David W; Glass, Christopher K.

J Biol Chem; 288(50): 35812-23, 2013 Dec 13.

Artículo en Inglés | MEDLINE | ID: mdl-24189069

8.

High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection.

Stark, Thomas J; Arnold, Justin D; Spector, Deborah H; Yeo, Gene W.

J Virol; 86(1): 226-35, 2012 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-22013051

9.

Infection of vascular endothelial cells with human cytomegalovirus under fluid shear stress reveals preferential entry and spread of virus in flow conditions simulating atheroprone regions of the artery.

DuRose, Jenny B; Li, Julie; Chien, Shu; Spector, Deborah H.

J Virol; 86(24): 13745-55, 2012 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-23055562

10.

A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization.

Strang, Blair L; Bender, Brian J; Sharma, Mayuri; Pesola, Jean M; Sanders, Rebecca L; Spector, Deborah H; Coen, Donald M.

J Virol; 86(20): 11066-77, 2012 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-22855486

11.

Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease.

Morello, Christopher S; Levinson, Michael S; Kraynyak, Kimberly A; Spector, Deborah H.

J Virol; 85(7): 3461-72, 2011 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-21270160

12.

Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.

Burgdorf, Sarah W; Clark, Charles L; Burgdorf, James R; Spector, Deborah H.

J Virol; 85(21): 11098-110, 2011 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-21865379

13.

SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus.

Branche, Emilie; Wang, Ying-Ting; Viramontes, Karla M; Valls Cuevas, Joan M; Xie, Jialei; Ana-Sosa-Batiz, Fernanda; Shafee, Norazizah; Duttke, Sascha H; McMillan, Rachel E; Clark, Alex E; Nguyen, Michael N; Garretson, Aaron F; Crames, Jan J; Spann, Nathan J; Zhu, Zhe; Rich, Jeremy N; Spector, Deborah H; Benner, Christopher; Shresta, Sujan; Carlin, Aaron F.

Nat Commun; 13(1): 5341, 2022 09 12.

Artículo en Inglés | MEDLINE | ID: mdl-36097162

14.

Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.

Sanders, Rebecca L; Spector, Deborah H.

J Virol; 84(10): 5158-70, 2010 May.

Artículo en Inglés | MEDLINE | ID: mdl-20200242

15.

Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription.

Tran, Karen; Mahr, Jeffrey A; Spector, Deborah H.

J Virol; 84(6): 3079-93, 2010 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-20042513

16.

Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.

Tran, Karen; Kamil, Jeremy P; Coen, Donald M; Spector, Deborah H.

J Virol; 84(20): 10832-43, 2010 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-20686030

17.

Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription.

Kapasi, Anokhi J; Clark, Charles L; Tran, Karen; Spector, Deborah H.

J Virol; 83(11): 5904-17, 2009 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-19297489

18.

IUGR and congenital cytomegalovirus infection.

Spector, Deborah H.

J Infect Dis; 209(10): 1497-9, 2014 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-24526739

19.

A vaccine containing highly purified virus particles in adjuvant provides high level protection against genital infection and disease in guinea pigs challenged intravaginally with homologous and heterologous strains of herpes simplex virus type 2.

Bernstein, David I; Morello, Christopher S; Cardin, Rhonda D; Bravo, Fernando J; Kraynyak, Kimberly A; Spector, Deborah H.

Vaccine; 38(1): 79-89, 2020 01 03.

Artículo en Inglés | MEDLINE | ID: mdl-31611098

20.

Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome.

Kapasi, Anokhi J; Spector, Deborah H.

J Virol; 82(1): 394-407, 2008 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-17942543

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