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1.
Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.
Bioorg Med Chem Lett;
23(11): 3443-7, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23597790
2.
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
Bioorg Med Chem Lett;
23(11): 3438-42, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23582272
3.
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
Nat Struct Mol Biol;
11(12): 1192-7, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15543157
4.
Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J Struct Biol;
162(1): 152-69, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18086534
5.
Characterization of substrate binding and catalysis in the potential antibacterial target N-acetylglucosamine-1-phosphate uridyltransferase (GlmU).
Protein Sci;
16(12): 2657-66, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18029420
6.
The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.
Biochemistry;
45(6): 1712-22, 2006 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-16460018
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