RESUMEN
Familial hypercholesterolemia (FH) is a form of primary hyperlipoproteinemia, is an autosomal co-dominant disorder, characterized by an increase in serum LDL cholesterol concentrations, presence of xanthomas and premature atherosclerosis. Homozygous familial hypercholesterolemia is of rare occurence in which approximately 1 in 1 million persons in the general population are affected. Here we report an interesting case of familial homozygous hypercholesterolemia for its classical presentation and rarity.
RESUMEN
Present study revealed the importance of endosulfan in mediating stress responses in Sorghum bicolor L. Moench (variety JP-1-1). The seeds treated with different concentrations (0.2, 0.4 and 0.6%) of endosulfan showed a significant decrease in percent germination over control. As the concentration increased, the shoot length, root length and biomass decreased. The amount of chlorophyll-a and protein decreased gradually with the increase in endosulfan concentration, whereas phenol and proline contents increased from 1.08 to 1.57 mg g(-1) and 0.18 to 0.98 mg g(-1), respectively. Chlorophyll-b decreased in 0.2% (0.97 mg g(-1)) as compared to control and revealed a gradual increase in 0.4% (1.11 mg g(-1)) and 0.6% (1.13 mg g(-1)). Endosulfan treatment suppressed the catalase and protease activity, but significantly increased the level of peroxidase, polyphenol oxidase, SOD and amylase enzymes. Lowerdose (0.2%) of endosulfan stimulated the activity of amylases.