Disparities in primary and emergency health care among "off-reserve" Indigenous females compared with non-Indigenous females aged 15-55 years in Canada.

BACKGROUND: Access to primary care protects the reproductive and non-reproductive health of females. We aimed to quantify health care disparities among "off-reserve" First Nations, Métis and Inuit females, compared with non-Indigenous females of reproductive age. METHODS: We used population-based data from cross-sectional cycles of the Canadian Community Health Survey (2015-2020), including 4 months during the COVID-19 pandemic. We included all females aged 15-55 years. We measured health care access, use and unmet needs, and quantified disparities through weighted and age-standardized absolute prevalence differences compared with non-Indigenous females. RESULTS: We included 2902 First Nations, 2345 Métis, 742 Inuit and 74 760 non-Indigenous females of reproductive age, weighted to represent 9.7 million people. Compared with non-Indigenous females, Indigenous females reported poorer health and higher morbidity, yet 4.2% (95% confidence interval [CI] 1.8% to 6.6%) fewer First Nations females and 40.7% (95% CI 34.3% to 47.1%) fewer Inuit females had access to a regular health care provider. Indigenous females waited longer for primary care, more used hospital services for nonurgent care, and fewer had consultations with dental professionals. Accordingly, 3.2% (95% CI 0.3% to 6.1%) more First Nations females and 4.0% (95% CI 0.7% to 7.3%) more Métis females reported unmet needs, especially for mental health (data for Inuit females not reported owing to high variability). INTERPRETATION: During reproductive age, Indigenous females in Canada face many disparities in health care access, use and unmet needs. Solutions aimed at increasing access to primary care are urgently needed to advance health care reconciliation.

Recent Patterns of Physical Activity and Sedentary Behaviour Among Pregnant Adults in Canada.

OBJECTIVE: To evaluate current levels of physical activity and sedentary behaviour among pregnant and non-pregnant adults in Canada. METHODS: We ascertained population-based cross-sectional data from the Canadian Community Health Survey (CCHS), 2015-2019, and the Canadian Health Measures Survey (CHMS), 2007-2019. We included adults who were assigned female at birth and were of reproductive age (aged 18-55 years) living in the provinces. We analyzed activity data from validated questionnaires and accelerometers. RESULTS: We included 53 765 adults from the CCHS and 5321 from the CHMS, weighted to represent 16 million people. Based on accelerometers, both pregnant and non-pregnant adults spent 9.5 hours per day (70% of their time) engaged in sedentary behaviour. Across all survey years, ages, and Canadian regions, pregnant adults, especially those aged under 35 years, spent less time engaged in moderate-to-vigorous physical activity (MVPA) compared with non-pregnant adults. Pregnant adults reported 34.3 minutes (95% CI 30.5-38.2) and objectively accrued 14.9 minutes (95% CI 7.9-21.8) in MVPA per day - 15.1 and 8.9 fewer minutes than non-pregnant adults, respectively. After accounting for self-report bias, only 27.5% (95% CI 24.1-31.0) of the pregnant and 41.1% (95% CI 40.4-41.9) of the non-pregnant adults met the Canadian physical activity guidelines (i.e., ≥150 minutes of MVPA per week). CONCLUSION: Physical activity levels are remarkably low among both pregnant and non-pregnant adults, with few meeting current guidelines. Given the substantial physical and mental health benefits, more support is needed to increase pre-pregnancy and prenatal activity in Canada.

Examining the role of pre-pregnancy weight and gestational weight gain in allergic disease development among offspring: A population-based cohort study in Ontario, Canada.

BACKGROUND: Studies suggest maternal weight and weight gain during pregnancy may influence foetal immunological development. However, their role in the aetiology of allergic disease is unclear. OBJECTIVES: We sought to examine the impact of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on the incidence of four common paediatric allergic diseases. METHODS: We conducted a retrospective, population-based cohort study of all singleton live births in Ontario, Canada between 2012 and 2014, using maternal-newborn records from the provincial birth registry linked with health administrative databases. Neonates were followed up to 7 years for anaphylaxis, asthma, dermatitis and rhinitis, identified through validated algorithms based on healthcare encounters. We multiply imputed missing data and employed Cox proportional-hazards models to calculate adjusted hazard ratios (aHR) with 95% confidence intervals (CI). To test the robustness of our findings, we also conducted several sensitivity analyses, including probabilistic bias analyses for exposure and outcome misclassification. All methods were prespecified in a published protocol. RESULTS: Of the 248,017 infants followed, 52% were born to mothers with a pre-pregnancy BMI in the normal range and only 19% were born to mothers with adequate weight gain during pregnancy. Incidence rates (per 100,000 person-days) for anaphylaxis, asthma, dermatitis and rhinitis were 0.22, 6.80, 12.41 and 1.54, respectively. Compared with normal BMI, maternal obesity was associated with increased hazards of asthma in offspring (aHR 1.08, 95% CI 1.05, 1.11), but decreased hazards of anaphylaxis (aHR 0.83, 95% CI 0.69, 0.99) and dermatitis (aHR 0.97, 95% CI 0.94, 0.99). In contrast, maternal underweight was associated with increased hazards of dermatitis (aHR 1.06, 95% CI 1.02, 1.10). We found no associations between pre-pregnancy BMI and rhinitis or GWG and any allergic outcome, and no evidence of effect measures modification by infant sex. CONCLUSIONS: These findings provide support for the involvement of maternal pre-pregnancy BMI in paediatric allergic disease development.

Evaluating the utility of self-reported questionnaire data to screen for dysglycemia in young adults: Findings from the US National Health and Nutrition Examination Survey.

Dysglycemia, including prediabetes and type 2 diabetes, is dangerous and widespread. Yet, the condition is transiently reversible and sequelae preventable, prompting the use of prediction algorithms to quickly assess dysglycemia status through self-reported data. However, as current algorithms have largely been developed in older populations, their application to younger adults is uncertain considering associations between risk factors and dysglycemia vary by age. We sought to identify sex-specific predictors of current dysglycemia among young adults and evaluate their ability to screen for prediabetes and undiagnosed diabetes. We analyzed 2005-2014 data from the National Health and Nutrition Examination Survey for 3251 participants aged 20-39, who completed an oral glucose tolerance test (OGTT), had not been diagnosed with diabetes, and, for females, were not pregnant. Sex-specific stepwise logistic models were fit with predictors identified from univariate analyses. Risk scores were developed using adjusted odds ratios and model performance was assessed using area under the curve (AUC) measures. The OGTT identified 906 (27.9%) and 78 (2.4%) participants with prediabetes or undiagnosed diabetes, respectively. Predictors of dysglycemia status for males were BMI, age, race, and first-degree family history of diabetes, and, in addition to those, education, delivered baby weight, waist circumference, and vigorous physical activity for females. Our male- and female-specific models demonstrated improved validity to assess dysglycemia presence among young adults relative to the widely-used American Diabetes Association test (AUC = 0.69 vs. 0.61; 0.92 vs. 0.71, respectively). Thus, age-specific scoring algorithms employing questionnaire data show promise and are effective in identifying dysglycemia among young adults.

Associations between paediatric obesity, chemical mixtures and environmental factors, in a national cross-sectional study of Canadian children.

BACKGROUND: Whilst single chemical exposures are suspected to be obesogenic, the combined role of chemical mixtures in paediatric obesity is not well understood. OBJECTIVES: We aimed to evaluate the potential associations between chemical mixtures and obesity in a population-based sample of Canadian children. METHODS: We ascertained biomonitoring and health data for children aged 3-11 from the cross-sectional Canadian Health Measures Survey from 2007 to 2019. Several chemicals of interest were measured in blood or urine and paediatric obesity was defined based on measured anthropometrics. Using quantile-based G computational analysis, we quantified the effects of three chemical mixtures selected a priori. Models were adjusted for sociodemographic and environmental factors identified through a directed acyclic graph. Results are presented through adjusted relative risks (RR) with 95% confidence intervals (95% CI). RESULTS: We included 9147 children. Of these, 24.1% were overweight or obese. Exposure to the mixture of bisphenol A, acrylamide, glycidamide, metals, parabens and arsenic increased the risk of childhood overweight or obesity by 45% (95% CI 1.09, 1.93), obesity by 109% (95% CI 1.27, 3.42) and central obesity by 82% (95% CI 1.30, 2.56). CONCLUSIONS: Our findings support the role of early childhood chemical exposures in paediatric obesity and the potential combined effects of chemicals.

Implementation of the CANRISK Tool: A Qualitative Exploration Among Allied Health Professionals in Canada.

OBJECTIVES: Launched in 2011 by the Public Health Agency of Canada, the Canadian Diabetes Risk Questionnaire (CANRISK) is a self-assessment tool validated in a Canadian sample, but its uptake has never been assessed. We sought to determine the level of current use of the CANRISK tool, identify common facilitators and barriers to its use and recommend future improvements. METHODS: Ten professional allied health organizations across Canada were contacted for in-depth interviews. Contextual content and thematic analysis were used to analyze the qualitative data set. RESULTS: According to allied health professionals, the tool is widely used, appealing and needed, and is being used for risk screening and health promotion. Respondents also identified the need to provide support and next steps for users identified as high risk. Still, several barriers to implementation were found, including readability, offensive or confusing language and difficulty ascertaining body measurements. CONCLUSIONS: The CANRISK is a valuable diabetes risk assessment tool in Canada, particularly for allied health organizations.

Examining the effects of pre-pregnancy weight and gestational weight gain on allergic disease development in offspring: a protocol for a population-based study using health administrative databases in Ontario, Canada.

Introduction: Over the last 20 years, excess maternal pre-pregnancy weight (overweight and obesity) and gestational weight gain have become the most common morbidities in pregnancy. These morbidities may pose a threat to fetal immunological development through associated metabolic dysfunction and inflammation and, as such, may partly explain the concurrent rise of paediatric allergic disease. We will examine the effect of maternal pre-pregnancy weight and gestational weight gain during pregnancy on the incidence of allergic diseases among offspring in Canada's most populous province. Methods and analysis: We will conduct a retrospective, population-based cohort study of all singleton live births to residents of Ontario, Canada in 2012-2013 and 2013-2014. The study population will be defined using maternal-newborn records from the provincial birth registry, which captures information on maternal pre-pregnancy weight and gestational weight gain. The cohort will be linked with provincial health administrative databases, allowing for follow-up of neonates through early childhood until 2019 (5-7 years of age). Allergic disease development (asthma, rhinitis, atopic dermatitis and anaphylaxis) will be ascertained using diagnostic codes from healthcare encounters. Potential confounders have been identified a priori through a directed acyclic graph. Cox proportional hazards regression models will be employed to assess the associations between maternal pre-pregnancy weight, gestational weight gain and incident paediatric allergic disease. Several preplanned sensitivity analyses will be conducted, including a probabilistic bias analysis of outcome misclassification. Ethics and dissemination: Ethics approval was obtained from the Research Ethics Board of the Children's Hospital of Eastern Ontario and the ICES Privacy Office. Findings will be disseminated in scientific conference presentations and peer-reviewed publications.

Are school-based measures of walkability and greenness associated with modes of commuting to school? Findings from a student survey in Ontario, Canada.

OBJECTIVES: In Canada, students are increasingly reliant on motorized vehicles to commute to school, and few meet the recommended overall physical activity guidelines. Infrastructure and built environments around schools may promote active commuting to and from school, thereby increasing physical activity. To date, few Canadian studies have examined this research question. METHODS: This study is a cross-sectional analysis of 11,006 students, aged 11-20, who participated in the 2016/2017 Ontario Student Drug Use and Health Survey. The remote sensing-derived Normalized Difference Vegetation Index (NDVI), at a buffer of 500 m from the schools' locations, was used to characterize greenness, while the 2016 Canadian Active Living Environments (Can-ALE) measure was used for walkability. Students were asked about their mode of regular commuting to school, and to provide information on several socio-demographic variables. Multivariable logistic regression models were used to quantify associations between active commuting and greenness and the Can-ALE. The resulting odds ratios, and their 95% confidence intervals, were adjusted for a series of risk factors that were collected from the survey. RESULTS: Overall, 21% of students reported active commuting (biking or walking) to school, and this prevalence decreased with increasing age. Students whose schools had higher Can-ALE scores were more likely to be active commuters. Specifically, the adjusted odds ratio (OR) of being an active commuter for schools in the highest quartile of the Can-ALE was 2.11 (95% CI = 1.64, 2.72) when compared with those in the lowest. For children, aged 11-14 years, who attended schools in high dwelling density areas, a higher odds of active commuting was observed among those in the upper quartile of greenness relative to the lowest (OR = 1.41; 95% CI = 0.92, 2.15). In contrast, for lower dwelling density areas, greenness was inversely associated with active commuting across all ages. CONCLUSION: Our findings suggest that students attending schools with higher Can-ALE scores are more likely to actively commute to school, and that positive impacts of greenness on active commuting are evident only in younger children in more densely populated areas. Future studies should collect more detailed data on residential measures of the built environment, safety, distance between home and school, and mixed modes of commuting behaviours.

RéSUMé: OBJECTIFS: Au Canada, les élèves comptent de plus en plus sur les véhicules à moteur pour faire le trajet entre la maison et l'école, et ils sont peu nombreux à avoir des niveaux d'activité physique globaux conformes aux recommandations des lignes directrices. Les infrastructures et les milieux bâtis autour des écoles pourraient promouvoir les déplacements actifs entre la maison et l'école, faisant ainsi augmenter l'activité physique. Jusqu'à maintenant toutefois, très peu d'études canadiennes ont examiné cette question de recherche. MéTHODE: La présente étude est une analyse transversale de 11 006 élèves de 11 à 20 ans ayant participé au Sondage sur la consommation de drogues et la santé des élèves de l'Ontario en 2016-2017. L'indice de végétation par différence normalisée (IVDN) dérivé par télédétection, utilisé dans un rayon de 500 m des établissements scolaires, a servi à caractériser la verdure, et l'indice d'accessibilité à la vie active dans les milieux de vie au Canada (AVA-Can) a servi à caractériser la marchabilité. Les élèves ont répondu à une question sur leur mode de transport habituel pour se rendre à l'école et donné des informations sur plusieurs variables sociodémographiques. Des modèles de régression logistique multivariée ont servi à chiffrer les associations entre les déplacements actifs, la verdure et l'AVA-Can. Les rapports de cotes ainsi obtenus, et leurs intervalles de confiance de 95 %, ont été ajustés en fonction d'une série de facteurs de risque retracés dans l'enquête. RéSULTATS: Dans l'ensemble, 21 % des élèves ont dit utiliser un mode de déplacement actif (vélo ou marche) pour se rendre à l'école, et cette prévalence était inversement liée à l'âge. Les élèves dont les écoles avaient un indice Can-ALE élevé étaient plus susceptibles d'employer un mode de transport actif. Spécifiquement, le rapport de cotes (RC) ajusté pour le fait de se rendre à l'école par un mode de transport actif dans le quartile supérieur de l'indice Can-ALE était de 2,11 (IC de 95 % = 1,64, 2,72) comparativement au quartile inférieur. Pour les enfants (11 à 14 ans) fréquentant des écoles dans des zones à forte densité d'habitation, des probabilités plus élevées de déplacements actifs ont été observées chez ceux du quartile de verdure supérieur que chez ceux du quartile inférieur (RC = 1,41; IC de 95 % = 0,92, 2,15). Par contre, dans les zones à faible densité d'habitation, la verdure étaient inversement associée aux déplacements actifs, à tout âge. CONCLUSION: Nos constatations indiquent que les élèves fréquentant des écoles dont l'indice Can-ALE est élevé sont plus susceptibles d'utiliser un mode de déplacement actif pour se rendre à l'école, et que l'effet positif de la verdure n'est manifeste que chez les jeunes enfants, dans les zones urbaines densément peuplées. Les études futures devraient obtenir des données plus détaillées sur les indicateurs résidentiels du milieu bâti, la sécurité, la distance entre la maison et l'école et les modes de déplacement mixtes.

At-a-glance - Living arrangements and health status of seniors in the 2018 Canadian Community Health Survey. / Aperçu - Conditions de logement et état de santé des aînés d'après l'Enquête sur la santé dans les collectivités canadiennes de 2018.

Currently, 1 in 3 Canadian seniors meet the criteria for successful aging, which include low probability of disease and disability, high cognitive and physical ability and active engagement in life. The sociodemographic characteristic of living alone can identify high-risk seniors, due to its association with lower social support and interactions, thus increasing susceptibility to negative health outcomes in older age. However, limited data exists on the living arrangements of Canadian seniors. In this analysis, we present sociodemographic characteristics and measures of health and social well-being of seniors by living arrangement. This information should be used to identify and support vulnerable seniors and increase the prevalence of healthy aging among Canadians.

An understanding of living arrangements may help those who develop intervention programs better target seniors at higher risk for negative health outcomes in older age. We found that seniors who were female, older, lower-income, divorced or separated, living in a population centre, renters and less educated were most likely to live alone. Seniors who were living alone were also more likely to report poor perceived health and social well-being. These results may be useful in targeting policies and programs aimed to improve health outcomes among seniors.

Une compréhension des conditions de logement pourrait aider les gens qui développent les programmes d'intervention à mieux cibler les aînés courant un risque plus élevé de problèmes de santé à un âge avancé. D'après nos résultats, les femmes, les personnes plus âgées, à faible revenu, divorcées ou séparées, vivant en milieu urbain, locataires et moins scolarisées étaient plus susceptibles de vivre seules. Les aînés vivant seuls étaient également plus susceptibles de faire état d'une perception défavorable de leur santé et de leur bien-être social. Ces résultats peuvent servir à mieux cibler les politiques et les programmes visant à améliorer l'état de santé des aînés.

Assessing Dysglycemia Risk Among Younger Adults: A Validation of the Canadian Diabetes Risk Questionnaire.

OBJECTIVES: The Canadian prevalence and incidence of diabetes has increased by the greatest extent in young adulthood. The original Canadian Diabetes Risk Questionnaire (CANRISK) was created to assess dysglycemia risk among adults ≥40 years of age, but it has not been validated among younger adults. Furthermore, it is unclear whether a young adult-specific risk score would better identify dysglycemia in this age group. METHODS: Analyses were done on participants who completed the self-administered CANRISK and underwent anthropometric and blood glucose measurements, were 18 to 39 years of age, were not pregnant and had no previous diabetes diagnosis. A risk model was generated from a lenient stepwise function fit with predictors identified through univariate analyses. Risk scores were produced from adjusted odds ratios. Model performance was internally validated using bootstrap methods and compared with the original CANRISK prognostic tool. RESULTS: Of the 3,334 participants included in the study, 194 (5.8%) and 51 (1.5%) were living with prediabetes or undiagnosed diabetes, respectively. The model displayed an area under the curve of 73.0%, adjusted to 72.9% after bootstrapping; however, using the original CANRISK model resulted in similar results (area under the curve, 71.4%). Sensitivity and specificity of the new and original models were also comparable (78.8% vs 77.1% and 54.0% vs 55.0%, respectively). CONCLUSIONS: The original CANRISK score performed well among young adults, even when compared with a young adult-specific model. We suggest that the cut point be lowered for young adults and the tool be permitted for use in this age group.

Impact of Maternal Malnutrition on Gut Barrier Defense: Implications for Pregnancy Health and Fetal Development.

Small intestinal Paneth cells, enteric glial cells (EGC), and goblet cells maintain gut mucosal integrity, homeostasis, and influence host physiology locally and through the gut-brain axis. Little is known about their roles during pregnancy, or how maternal malnutrition impacts these cells and their development. Pregnant mice were fed a control diet (CON), undernourished by 30% vs. control (UN), or fed a high fat diet (HF). At day 18.5 (term = 19), gut integrity and function were assessed by immunohistochemistry and qPCR. UN mothers displayed reduced mRNA expression of Paneth cell antimicrobial peptides (AMP; Lyz2, Reg3g) and an accumulation of villi goblet cells, while HF had reduced Reg3g and mucin (Muc2) mRNA and increased lysozyme protein. UN fetuses had increased mRNA expression of gut transcription factor Sox9, associated with reduced expression of maturation markers (Cdx2, Muc2), and increased expression of tight junctions (TJ; Cldn-7). HF fetuses had increased mRNA expression of EGC markers (S100b, Bfabp, Plp1), AMP (Lyz1, Defa1, Reg3g), and TJ (Cldn-3, Cldn-7), and reduced expression of an AMP-activator (Tlr4). Maternal malnutrition altered expression of genes that maintain maternal gut homeostasis, and altered fetal gut permeability, function, and development. This may have long-term implications for host-microbe interactions, immunity, and offspring gut-brain axis function.

Assessing the Impact of School-Based Greenness on Mental Health Among Adolescent Students in Ontario, Canada.

Neighbourhood greenness has been frequently associated with improved mental health in adulthood, yet its impact among youth is less clear. Additionally, though youth spend large portions of time at school, no study has investigated associations between school-based measures of greenness and students' mental health in Canada. We addressed this gap by linking participant responses from the 2016-2017 Ontario Student Drug Use and Health Survey to school-based features of the built environment. Our analyses included 6313 students, ages 11-20. Measures of greenness were the mean and max of the annual mean Normalized Difference Vegetation Index within 500 m and 1000 m from the centroid of the school postal code. Measures of mental health included: serious psychological distress (Kessler 6-item Psychological Distress Scale), self-rated mental health (using a five-point Likert scale), suicide ideation, and suicide attempt. In our study population, the prevalence of serious psychological distress and low self-rated mental health was 16.7% and 20.3%, respectively. Suicide ideation was reported by 13.5% of participants, while 3.7% reported a suicide attempt. Quantity of greenness was similar between schools in the lower and upper quartiles. In logistic regressions, we found no association between objective school-based greenness and mental health, as assessed by multiple measures, both before and after adjustment. Null findings held true after stratification by season, as well. Whether other characteristics of school greenness (such as type, quality, or access and use) are more impactful to students' mental health should be a focus of future analyses.