Detalles de la búsqueda
1.
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature;
504(7480): 437-40, 2013 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24226772
2.
Next-generation small molecule therapies for heart failure: 2015 and beyond.
Bioorg Med Chem Lett;
28(9): 1429-1435, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29615340
3.
Nonracemic synthesis of GK-GKRP disruptor AMG-3969.
J Org Chem;
79(8): 3684-7, 2014 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-24678849
4.
Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.
Bioorg Med Chem Lett;
23(24): 6625-8, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24215889
5.
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.
Cancer Discov;
13(11): 2432-2447, 2023 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37623743
6.
Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion.
J Pharmacol Exp Ther;
337(3): 681-91, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21422163
7.
Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2.
Bioorg Med Chem Lett;
21(18): 5191-6, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21824779
8.
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.
Bioorg Med Chem Lett;
20(18): 5544-7, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20708930
9.
A tandem cross-coupling/S(N)Ar approach to functionalized carbazoles.
Org Lett;
9(23): 4893-6, 2007 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-17939678
10.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
J Med Chem;
58(11): 4462-82, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25914941
11.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N â S (nN â σ*S-X) Interaction for Conformational Constraint.
J Med Chem;
58(24): 9663-79, 2015 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26551034
12.
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
ACS Med Chem Lett;
6(9): 987-92, 2015 Sep 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26396685
13.
Discovery of Small-Molecule Glucokinase Regulatory Protein Modulators That Restore Glucokinase Activity.
J Biomol Screen;
19(7): 1014-23, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24717911
14.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
J Med Chem;
57(14): 5949-64, 2014 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-25001129
15.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
J Med Chem;
57(7): 3094-116, 2014 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24611879
16.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
J Med Chem;
57(2): 309-24, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405172
17.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
J Med Chem;
57(2): 325-38, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405213
18.
Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.
ACS Med Chem Lett;
2(11): 824-7, 2011 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900270
19.
From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).
J Med Chem;
54(16): 5836-57, 2011 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-21707077
20.
Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).
J Med Chem;
53(11): 4481-7, 2010 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-20465278