Survival, Neurologic Injury, and Kidney Function after Surgery for Acute Type A Aortic Dissection.

BACKGROUND: To analyze survival, neurologic injury, and kidney function after acute type A aortic dissection. METHODS: A total of 445 patients undergoing surgery for acute type A aortic dissection were analyzed. Evaluation according to risk factors for mortality, neurologic injury, and kidney function was performed. RESULTS: Overall 1-, 5-, and 10-year survival rates were 82.8 ± 1.8%, 73.6 ± 2.4%, and 59.3 ± 3.9, respectively. Independent preoperative risk factors for mortality were preexisting renal impairment (p = 0.001), reduced left ventricular ejection fraction (p < 0.001), and age (p < 0.001). Perioperative risk factors were prolonged cross-clamp (p < 0.001) and cerebral perfusion time (p = 0.001). Risk factors for renal failure were preexisting renal impairment (p < 0.001), prolonged cross-clamp time (p < 0.001), cerebral perfusion time (p < 0.001), and age (p = 0.022). Risk factors for neurologic injury were cross-clamp time (p = 0.038), cerebral perfusion time (p = 0.007), and age (p = 0.045). CONCLUSION: In addition to classic risk factors, survival after type A aortic dissection is affected by preexisting renal impairment. Preexisting renal impairment is predictive of postoperative renal failure. Therefore treatment and prevention strategies for renal failure during the acute and long-term course after acute type A aortic dissection are warranted.

External validation of scores proposed for estimation of survival probability of patients with severe adult respiratory distress syndrome undergoing extracorporeal membrane oxygenation therapy: a retrospective study.

INTRODUCTION: This study was designed as an external validation of the recently proposed Predicting Death for Severe ARDS on V-V ECMO (PRESERVE) score, The respiratory extracorporeal membrane oxygenation survival prediction (RESP) score and a scoring system developed for externally retrieved patients on extracorporeal membrane oxygenation (ECMO) at our institution. All scores are proposed for the estimation of survival probability after ECMO treatment for severe adult respiratory distress syndrome. METHODS: Data from 51 patients (2008 to 2013) were analyzed in this retrospective single-center study. A calculation of an adapted PRESERVE score, the RESP score as well as the score developed for externally retrieved ECMO patients was performed. RESULTS: Seventy one percent of patients received veno-venous (v-v) and 29% venous-arterial (v-a) ECMO support during the study period. Overall survival at 6 months was 55%, with a 61% survival rate for v-v cannulated patients and a 40% survival rate for v-a cannulated patients. The PRESERVE score discriminated survivors and non-survivors with an area under the curve of 0.67 (95% CI 0.52 to 0.82, P = 0.03). Analyzing survival prediction according to cannulation modus, the PRESERVE score and the RESP score significantly predicted survival for patients on v-v ECMO with an area under the curve of 0.75 (95% CI 0.57 to 0.92, P = 0.01) and 0.81 (95% CI 0.67 to 0.95, P = 0.035), respectively, while the scoring system developed for externally retrieved ECMO patients failed to predict survival in our study population. All scores failed to predict mortality for patients on v-a ECMO. CONCLUSION: Our single-center validation confirms that the proposed PRESERVE and RESP score predict survival for patients treated with v-v ECMO for severe adult respiratory distress syndrome.

Completely epicardial implantation of a cardiac resynchronization therapy defibrillator using a minimal invasive approach.

We report the case of a successful completely epicardial implantation of a cardiac resynchronization defibrillator using a minimal invasive approach in a 55-year-old patient with dilated cardiomyopathy and a history of three cardiac surgical procedures of the aortic root, the ascending aorta and the aortic arch. Due to a chronic Q fever the patient was regarded unsuitable for a transvenous implantation.

Uncommon cause of ventricular tachycardia in a patient with a giant pseudoaneurysm of the ascending aorta.

Ventricular arrhythmias occur predominantly in patients with structural heart disease. The most common substrate is scarring due to ischemic heart disease. We present an uncommon cause of ventricular tachycardia due to excessive right coronary artery stretch in a patient with a giant pseudoaneurysm of the ascending aorta years after aortic root repair.

Impact of a femoral snare approach as a bailout procedure on success rates in lead extractions.

OBJECTIVES: In cases of challenging transvenous lead extraction procedures, limitations exist for the subclavian approach (SCA). In case of absent alternative approaches, the procedure may end with failure. Therefore, we investigated the femoral snare approach (FSA) as bailout procedure. METHODS: From December 2010 to August 2013, 114 patients with 190 leads were scheduled for transvenous lead extraction procedures [mean implant duration (MID): 74.7 (1-384) months]. In 28 leads [MID: 133.8 (36-384) months] the FSA was used. In 20 leads [MID: 127.5 (52-258) months] the FSA was performed as bailout approach and in 8 leads [MID: 149.6 (36-384) months] as first-line approach due to complete intravascular lead position. RESULTS: In all FSA procedures (n = 28), clinical success was 85.7% and complete procedural success 64.3%. In FSA procedures as bailout approach (n = 20), clinical success was 80.0% and complete procedural success 55.0%. In first-line FSA procedures (n = 8), clinical success was 100.0% and complete procedural success 87.5%. Overall (n = 190) clinical success was 96.3%, complete procedural success 91.1%. By adding the FSA in cases of insufficient or impossible SCA, clinical success was increased by 12.6% (from 83.7 to 96.3%) and complete procedural success by 9.5% (from 81.6 to 91.1%). Comparison of leads extracted by SCA with leads extracted by FSA revealed that MID [133.8 (36-384) vs 64.4 (1-300) months; P < 0.0001] and the rate of passive fixation leads (67.9 vs 28.4%; P < 0.0001) were significantly higher in the FSA group. CONCLUSIONS: In cases of failed or impossible subclavian approach, the femoral snare approach may improve overall success rates without relevantly increasing operative risk.

Frailty is a predictor of short- and mid-term mortality after elective cardiac surgery independently of age.

OBJECTIVES: Assessment of perioperative risk of elderly patients in cardiac surgery is difficult, and most of the common risk scores show over- or underestimation. Two frailty scores, the comprehensive assessment of frailty (CAF) score and the Frailty predicts death One yeaR after CArdiac Surgery Test (FORECAST), were developed as additional tools to estimate the preoperative mortality risk, taking into consideration the frailty status of elderly patients. METHODS: Four hundred and fifty patients who were referred for elective cardiac surgery were included. All the patients were assessed with the CAF test and the FORECAST. Thirty-day and 1-year mortality were evaluated by telephone interview. Univariate and bivariate logistic regression were performed to test the predictive power of the tests on mortality. Correlation of the scores with age was calculated with Spearman ranks. Three commensurate groups were built for each of the frailty scores and the outcome was compared between the groups. All analyses were performed for Society of Thoracic Surgeons (STS) and European System for Cardiac Operative Risk Evaluation (EuroSCORE) accordingly. RESULTS: A total of 227 male and 223 female patients were included. Thirty-day mortality was 6.1%, and 1-year mortality was 13.3%. Logistic regression showed that both scores are able to predict 30-day as well as 1-year mortality. Bivariate logistic regression showed that both frailty scores give relevant additional information to the STS and EuroSCORE for the prediction of 1-year mortality. The frailty scores were only weakly correlated with age in contrast to STS and EuroSCORE and therefore can be used as indicator of the biological age of patients besides the numerical age. Survival up to 1 year was relevantly reduced in the group of patients with the higher frailty scores. CONCLUSIONS: CAF and FORECAST are additional tools to evaluate elderly patients adequately before elective cardiac surgery, and showed an association with short- and mid-term mortality independently of age.

Novel emboli protection system during cardiac surgery: a multi-center, randomized, clinical trial.

BACKGROUND: Stroke is a major cause of morbidity and mortality during open-heart surgery. Up to 60% of intraoperative cerebral events are emboli induced. This randomized, controlled, multicenter trial is the first human study evaluating the safety and efficacy of a novel aortic cannula producing simultaneous forward flow and backward suction for extracting solid and gaseous emboli from the ascending aorta and aortic arch upon their intraoperative release. METHODS: Sixty-six patients (25 females; 68±10 years) undergoing elective aortic valve replacement surgery, with or without coronary artery bypass graft surgery, were randomized to the use of the CardioGard (CardioGard Medical, Or-Yehuda, Israel) Emboli Protection cannula ("treatment") or a standard ("control") aortic cannula. The primary endpoint was the volume of new brain lesions measured by diffusion-weighted magnetic resonance imaging (DW-MRI), performed preoperatively and postoperatively. Device safety was investigated by comparisons of complications rate, namely neurologic events, stroke, renal insufficiency and death. RESULTS: Of 66 patients (34 in the treatment group), 51 completed the presurgery and postsurgery MRI (27 in the treatment group). The volume of new brain lesion for the treatment group was (mean±standard error of the mean) 44.00±64.00 versus 126.56±28.74 mm3 in the control group (p=0.004). Of the treatment group, 41% demonstrated new postoperative lesions versus 66% in the control group (p=0.03). The complication rate was comparable in both groups. CONCLUSIONS: The CardioGard cannula is safe and efficient in use during open-heart surgery. Efficacy was demonstrated by the removal of a substantial amount of emboli, a significant reduction in the volume of new brain lesions, and the percentage of patients experiencing new brain lesions.