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1.

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T.

Nat Immunol; 21(5): 535-545, 2020 05.

Artículo en Inglés | MEDLINE | ID: mdl-32313245

2.

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T.

Nat Immunol; 18(2): 236-245, 2017 02.

Artículo en Inglés | MEDLINE | ID: mdl-28024152

3.

In vivo ablation of NF-κB cascade effectors alleviates disease burden in myeloproliferative neoplasms.

Laranjeira, Angelo B A; Kong, Tim; Snyder, Steven C; Fulbright, Mary C; Fisher, Daniel A C; Starczynowski, Daniel T; Oh, Stephen T.

Blood; 143(23): 2414-2424, 2024 Jun 06.

Artículo en Inglés | MEDLINE | ID: mdl-38457657

4.

Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML.

Bennett, Joshua; Ishikawa, Chiharu; Agarwal, Puneet; Yeung, Jennifer; Sampson, Avery; Uible, Emma; Vick, Eric; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Kolt, Amal; Choi, Kwangmin; Volk, Andrew; Greis, Kenneth D; Rosenbaum, Jan; Hoyt, Scott B; Thomas, Craig J; Starczynowski, Daniel T.

Blood; 142(11): 989-1007, 2023 09 14.

Artículo en Inglés | MEDLINE | ID: mdl-37172199

5.

Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salamonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T.

Nat Immunol; 18(4): 474, 2017 03 22.

Artículo en Inglés | MEDLINE | ID: mdl-28323261

6.

Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation.

Muto, Tomoya; Walker, Callum S; Agarwal, Puneet; Vick, Eric; Sampson, Avery; Choi, Kwangmin; Niederkorn, Madeline; Ishikawa, Chiharu; Hueneman, Kathleen; Varney, Melinda; Starczynowski, Daniel T.

Haematologica; 108(10): 2715-2729, 2023 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-37102608

7.

ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms.

Riabov, Vladimir; Xu, Qingyu; Schmitt, Nanni; Streuer, Alexander; Ge, Guo; Bolanos, Lyndsey; Wunderlich, Mark; Jann, Johann-Christoph; Wein, Alina; Altrock, Eva; Demmerle, Marie; Mukherjee, Sanjay; Ali, Abdullah Mahmood; Rapp, Felicitas; Nowak, Verena; Weimer, Nadine; Obländer, Julia; Palme, Iris; Göl, Melda; Jawhar, Ahmed; Darwich, Ali; Wuchter, Patrick; Weiss, Christel; Raza, Azra; Foulks, Jason M; Starczynowski, Daniel T; Yang, Feng-Chun; Metzgeroth, Georgia; Steiner, Laurenz; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Nowak, Daniel.

Haematologica; 2023 Nov 02.

Artículo en Inglés | MEDLINE | ID: mdl-37916386

8.

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies.

Bennett, Joshua; Starczynowski, Daniel T.

Curr Opin Hematol; 29(1): 8-19, 2022 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-34743084

9.

Chronic immune response dysregulation in MDS pathogenesis.

Barreyro, Laura; Chlon, Timothy M; Starczynowski, Daniel T.

Blood; 132(15): 1553-1560, 2018 10 11.

Artículo en Inglés | MEDLINE | ID: mdl-30104218

10.

Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages.

Kong, Fansheng; Liu, Zhiwei; Jain, Viral G; Shima, Kenjiro; Suzuki, Takuji; Muglia, Louis J; Starczynowski, Daniel T; Pasare, Chandrashekhar; Bhattacharyya, Sandip.

J Immunol; 199(10): 3654-3667, 2017 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-29038250

11.

Are DDX41 variants of unknown significance and pathogenic variants created equal?

Xie, Zhuoer; Starczynowski, Daniel T.

Haematologica; 108(11): 2883-2885, 2023 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-37317927

12.

HHEX expression drives AML development.

Starczynowski, Daniel T.

Blood; 136(14): 1575-1576, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-33002120

13.

Errant innate immune signaling in del(5q) MDS.

Starczynowski, Daniel T.

Blood; 124(5): 669-71, 2014 Jul 31.

Artículo en Inglés | MEDLINE | ID: mdl-25082861

14.

Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1.

Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T.

Blood; 120(4): 858-67, 2012 Jul 26.

Artículo en Inglés | MEDLINE | ID: mdl-22685174

15.

Dysregulated innate immune signaling cooperates with RUNX1 mutations to transform an MDS-like disease to AML.

Barreyro, Laura; Sampson, Avery M; Hueneman, Kathleen; Choi, Kwangmin; Christie, Susanne; Ramesh, Vighnesh; Wyder, Michael; Wang, Dehua; Pujato, Mario; Greis, Kenneth D; Huang, Gang; Starczynowski, Daniel T.

iScience; 27(6): 109809, 2024 Jun 21.

Artículo en Inglés | MEDLINE | ID: mdl-38784013

16.

Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression.

Matsui, Shinichiro; Ri, Chihiro; Bolanos, Lyndsey C; Choi, Kwangmin; Shibamiya, Asuka; Ishii, Arata; Takaishi, Koji; Oshima-Hasegawa, Nagisa; Tsukamoto, Shokichi; Takeda, Yusuke; Mimura, Naoya; Yoshimi, Akihide; Yokote, Koutaro; Starczynowski, Daniel T; Sakaida, Emiko; Muto, Tomoya.

Leukemia; 38(5): 1032-1045, 2024 May.

Artículo en Inglés | MEDLINE | ID: mdl-38609495

17.

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation.

Venkatasubramanian, Meenakshi; Schwartz, Leya; Ramachandra, Nandini; Bennett, Joshua; Subramanian, Krithika R; Chen, Xiaoting; Gordon-Mitchell, Shanisha; Fromowitz, Ariel; Pradhan, Kith; Shechter, David; Sahu, Srabani; Heiser, Diane; Scherle, Peggy; Chetal, Kashish; Kulkarni, Aishwarya; Myers, Kasiani C; Weirauch, Matthew T; Grimes, H Leighton; Starczynowski, Daniel T; Verma, Amit; Salomonis, Nathan.

bioRxiv; 2024 Feb 08.

Artículo en Inglés | MEDLINE | ID: mdl-38370617

18.

Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations.

Starczynowski, Daniel T; Morin, Ryan; McPherson, Andrew; Lam, Jeff; Chari, Raj; Wegrzyn, Joanna; Kuchenbauer, Florian; Hirst, Martin; Tohyama, Kaoru; Humphries, R Keith; Lam, Wan L; Marra, Marco; Karsan, Aly.

Blood; 117(2): 595-607, 2011 Jan 13.

Artículo en Inglés | MEDLINE | ID: mdl-20962326

19.

Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells.

Kuchenbauer, Florian; Mah, Sarah M; Heuser, Michael; McPherson, Andrew; Rüschmann, Jens; Rouhi, Arefeh; Berg, Tobias; Bullinger, Lars; Argiropoulos, Bob; Morin, Ryan D; Lai, David; Starczynowski, Daniel T; Karsan, Aly; Eaves, Connie J; Watahiki, Akira; Wang, Yuzhuo; Aparicio, Samuel A; Ganser, Arnold; Krauter, Jürgen; Döhner, Hartmut; Döhner, Konstanze; Marra, Marco A; Camargo, Fernando D; Palmqvist, Lars; Buske, Christian; Humphries, R Keith.

Blood; 118(12): 3350-8, 2011 Sep 22.

Artículo en Inglés | MEDLINE | ID: mdl-21628414

20.

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis.

Guo, Fukun; Zhang, Shuangmin; Grogg, Matthew; Cancelas, Jose A; Varney, Melinda E; Starczynowski, Daniel T; Du, Wei; Yang, Jun-Qi; Liu, Wei; Thomas, George; Kozma, Sara; Pang, Qishen; Zheng, Yi.

Haematologica; 98(9): 1353-8, 2013 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-23716557

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