RESUMEN
Rheological properties of erythrocytes from patients with high risk of cardiovascular disease (CVD) were analyzed in relation to individual patient risk factors as well as to the medication. Additionally, comparative statistical analysis was performed considering plasma concentration of the selected mediators of vascular endothelium: 6-keto-prostaglandin F(1alpha) (PGF(1alpha)), sVCAM-1 and E-selectin adhesion molecules and interleukin-6 (IL-6). It was found that antihypertensive therapy with angiotensin-converting enzyme inhibitor (ACEI) is accompanied by improvement of RBC rheology: the increase of deformability and the decrease of aggregability. This improvement is probably mediated by endothelial prostacyclin and nitric oxide which are generated by ACEI. A correlation was observed between RBC deformability/aggregability and the patient's hematocrit level, what implicates that the hematocrit level should be explicitly taken into consideration when investigating rheological properties of erythrocytes. A strong relationship was also found between the plasma concentration of sVCAM-1 and patient's age.
Asunto(s)
Enfermedades Cardiovasculares/diagnóstico , Enfermedades Cardiovasculares/patología , Eritrocitos/citología , Reología/métodos , Anciano , Inhibidores de la Enzima Convertidora de Angiotensina/farmacología , Selectina E/metabolismo , Epoprostenol/farmacología , Agregación Eritrocitaria , Deformación Eritrocítica , Femenino , Humanos , Interleucina-6/metabolismo , Masculino , Persona de Mediana Edad , Factores de RiesgoRESUMEN
In recent years, a single ion hit facility has been constructed at the IFJ ion microprobe. The setup is used for the precise irradiations of living cells by a controlled number of ions. Investigations of such type have two very important requirements: (1) cells must be examined in their natural state and environment (i.e. without previously being killed, preferentially neither fixed nor stained) and (2) the possibility of automatic irradiation of large number of cells (including computer recognition of cells positions) must be provided. This work presents some of the crucial features of the off-line and on-line optical systems, including self-developed software responsible for automatic cell recognition.
Asunto(s)
Técnicas de Cultivo de Célula/instrumentación , Separación Celular/instrumentación , Iones Pesados , Interpretación de Imagen Asistida por Computador/métodos , Microscopía/instrumentación , Aceleradores de Partículas/instrumentación , Radiometría/instrumentación , Técnicas de Cultivo de Célula/métodos , Separación Celular/métodos , Diseño de Equipo , Análisis de Falla de Equipo , Alemania , Interpretación de Imagen Asistida por Computador/instrumentación , Iones , Microscopía/métodos , Miniaturización , Sistemas en Línea , Dosis de Radiación , Radiometría/métodos , Sensibilidad y Especificidad , Evaluación de la Tecnología BiomédicaRESUMEN
The gamma decay from Coulomb excitation of 68Ni at 600 MeV/nucleon on a Au target was measured using the RISING setup at the fragment separator of GSI. The 68Ni beam was produced by a fragmentation reaction of 86Kr at 900 MeV/nucleon on a 9Be target and selected by the fragment separator. The gamma rays produced at the Au target were measured with HPGe detectors at forward angles and with BaF2 scintillators at backward angles. The measured spectra show a peak centered at approximately 11 MeV, whose intensity can be explained in terms of an enhanced strength of the dipole response function (pygmy resonance). Such pygmy structure has been predicted in this unstable neutron-rich nucleus by theory.
RESUMEN
The gamma decay associated with the warm rotation of the superdeformed nuclei 151Tb and 196Pb has been measured with the EUROBALL IV array. Several independent quantities provide a stringent test of the population and decay dynamics in the superdeformed well. A Monte Carlo simulation of the gamma decay based on microscopic calculations gives remarkable agreement with the data only assuming a large enhancement of the B(E1) strength for 1-2 MeV gamma rays, which may be related to the evidence for octupole vibrations in both mass regions.