1.
Org Lett
; 16(6): 1672-5, 2014 Mar 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24597689
RESUMEN
The tetrasubstituted pyridinium amino acids isodesmosine and desmosine are cross-linkers of elastin and are attractive biomarkers for the diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the biomimetic total synthesis of isodesmosine and desmosine via a lanthanide-promoted Chichibabin pyridine synthesis using the corresponding aldehyde and amine hydrochloride is reported.