On the optimization of 3D inflow-based vascular-space-occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa).

PURPOSE: The inflow-based vascular-space-occupancy (iVASO) MRI was originally developed in a single-slice mode to measure arterial cerebral blood volume (CBVa). When vascular crushers are applied in iVASO, the signals can be sensitized predominantly to small pial arteries and arterioles. The purpose of this study is to perform a systematic optimization and evaluation of a 3D iVASO sequence on both 3 T and 7 T for the quantification of CBVa values in the human brain. METHODS: Three sets of experiments were performed in three separate cohorts. (1) 3D iVASO MRI protocols were compared to single-slice iVASO, and the reproducibility of whole-brain 3D iVASO MRI was evaluated. (2) The effects from different vascular crushers in iVASO were assessed. (3) 3D iVASO MRI results were evaluated in arterial and venous blood vessels identified using ultrasmall-superparamagnetic-iron-oxides-enhanced MRI to validate its arterial origin. RESULTS: 3D iVASO scans showed signal-to-noise ratio (SNR) and CBVa measures consistent with single-slice iVASO with reasonable intrasubject reproducibility. Among the iVASO scans performed with different vascular crushers, the whole-brain 3D iVASO scan with a motion-sensitized-driven-equilibrium preparation with two binomial refocusing pulses and an effective TE of 50 ms showed the best suppression of macrovascular signals, with a relatively low specific absorption rate. When no vascular crusher was applied, the CBVa maps from 3D iVASO scans showed large CBVa values in arterial vessels but well-suppressed signals in venous vessels. CONCLUSION: A whole-brain 3D iVASO MRI scan was optimized for CBVa measurement in the human brain. When only microvascular signals are desired, a motion-sensitized-driven-equilibrium-based vascular crusher with binomial refocusing pulses can be applied in 3D iVASO.

Concurrent measurement of perfusion parameters related to small blood vessels and cerebrospinal fluid circulation in the human brain using dynamic dual-spin-echo perfusion MRI.

Accumulating evidence from recent studies has indicated the importance of studying the interaction between the microvascular and lymphatic systems in the brain. To date, most imaging methods can only measure blood or lymphatic vessels separately, such as dynamic susceptibility contrast (DSC) MRI for blood vessels and DSC MRI-in-the-cerebrospinal fluid (CSF) (cDSC MRI) for lymphatic vessels. An approach that can measure both blood and lymphatic vessels in a single scan offers advantages such as a halved scan time and contrast dosage. This study attempts to develop one such approach by optimizing a dual-echo turbo-spin-echo sequence, termed "dynamic dual-spin-echo perfusion (DDSEP) MRI". Bloch simulations were performed to optimize the dual-echo sequence for the measurement of gadolinium (Gd)-induced blood and CSF signal changes using a short and a long echo time, respectively. The proposed method furnishes a T1-dominant contrast in CSF and a T2-dominant contrast in blood. MRI experiments were performed in healthy subjects to evaluate the dual-echo approach by comparing it with existing separate methods. Based on simulations, the short and long echo time were chosen around the time when blood signals show maximum difference between post- and pre-Gd scans, and the time when blood signals are completely suppressed, respectively. The proposed method showed consistent results in human brains as previous studies using separate methods. Signal changes from small blood vessels occurred faster than from lymphatic vessels after intravenous Gd injection. In conclusion, Gd-induced signal changes in blood and CSF can be detected simultaneously in healthy subjects with the proposed sequence. The temporal difference in Gd-induced signal changes from small blood and lymphatic vessels after intravenous Gd injection was confirmed using the proposed approach in the same human subjects. Results from this proof-of-concept study will be used to further optimize DDSEP MRI in subsequent studies.

Design of a free-form off-axis three-mirror optical system with a low f-number based on the same substrate.

In this paper, we design a free-form off-axis three-mirror optical system with a low f-number and compact structure, which can be used as an infrared reflection imager. The initial structure is calculated from the near-axis optical transfer matrix based on third-order aberration theory. Particular constraints are designed to install all mirrors on the same substrate for simultaneous milling, which reduces the processing difficulty and effectively avoids errors caused by component assembly. Zernike free-form surfaces are introduced to correct aberrations. This optical system has a field of view of 5∘×5∘ and an f-number of 1.82; the modulation transfer function of the system is higher than 0.6 at 30 lp/mm. The results of the tolerance assignment of the system were verified by the Monte Carlo method, and the machining tolerance is reasonable and easy to achieve. This design not only improves the optical performance of the system but also enhances the feasibility of manufacturing.

Free-form off-axis three-mirror optical antenna design with an integrated primary/tertiary-mirror structure.

In order to improve the performance and simplify the structure of an optical antenna for a space laser communication system, we design a free-form off-axis three-mirror optical antenna with an integrated primary/tertiary-mirror structure. The adoption of the integrated primary/tertiary-mirror structure improves efficiency of light energy utilization and reduces the complexity of optical processing and assembly. The introduction of free-form optical elements and optical structure constraints helps to correct the off-axis aberration and realize a large field of view. The obtained optical antenna has the magnification of five times and field of view of 2.4∘×2.4∘. The image quality obtained here reaches the diffraction-limited level. At the communication wavelength of 808 nm, the wavefront error is better than λ/22, and the system has a high energy concentration. The proposed optical antenna could not only improve tracking accuracy of the optical antenna in space but also greatly reduce the complexity of the laser communication system. It has reference significance and application value for free-space laser communication.