1.
Bioorg Med Chem Lett
; 16(4): 989-94, 2006 Feb 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16297617
RESUMEN
A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activity, a typical liability of 4-substituted imidazoles, have been established.