1.
Bioorg Med Chem Lett
; 13(17): 2907-11, 2003 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-14611855
RESUMEN
A series of greatly simplified microcystin analogues comprised only of Adda (the beta-amino acid common to the microcystins, nodularins, and motuporin,) and a single additional amino acid residue was synthesized and screened for inhibition of the protein phosphatases 1 and 2A. Several of the analogues were shown to be mid-nanomolar inhibitors of the enzymes.