ERP correlates of self-referential processing moderate the association between pubertal status and disordered eating in preadolescence.

Preadolescence is a critical period for the onset of puberty and eating-related psychopathology. More advanced pubertal status is associated with elevated eating pathology. However, it was unclear whether this association was moderated by self-referential processing, an important, modifiable cognitive risk for various forms of psychopathology, including eating problems. Further, no study has examined the neural correlates of self-referential processing in relation to eating pathology. To address these gaps, we examined how the association between pubertal status and disordered eating was moderated by self-referential processing in a community sample of 115 nine-to-12-year-old preadolescents (66 girls; mean age/SD = 10.98/1.18 years; 87.5% White). Youths reported their pubertal status and disordered eating behaviors and completed an ERP version of the Self-Referent Encoding Task (SRET) to assess self-referential processing. A Principal Component Analysis of the ERP data identified an anterior late positive potential (LPP) in both the positive and negative SRET conditions. The LPP in the positive condition moderated the positive association between pubertal status and disordered eating behaviors, such that this association was significant for youths with a smaller LPP toward positive self-referential cues, but non-significant for those showing a larger LPP toward positive self-referential cues. These results suggest that a deeper processing of positive self-referential information, indicated by a potentiated LPP, may weaken the negative impact of pubertal status on disordered eating. Our findings also suggest that enhancing positive self-referential processing may be a useful tool in preventing the development of eating pathology in preadolescents, especially for those with more advanced pubertal status.

Late Positive Potential Elicited by Monetary Reward Feedback Predicts Changes of Disordered Eating From Age 11 to Age 12 in Community-Dwelling Girls.

OBJECTIVE: Early adolescence is marked by elevated psychopathology, including disrupted eating attitudes and behaviors. Reward processing is an identified mechanism in portending eating pathology, that is, aberrant reward responsivity may contribute to disrupted reward-seeking behaviors (e.g., food consuming). This literature has focused on adults or mid-to-late adolescents, with little work done on early adolescence. We examined the linkages between reward feedback processing, indexed by event-related potentials (ERPs), and changes of emerging disordered eating in community-dwelling early adolescents. METHOD: At T1, 115 youths (66 girls, mean/SD age = 11.00/1.16 years) completed an EEG monetary reward Doors task. Youths completed the Eating Disorder Examination-Questionnaire Short at T1 and ~6 months (T2) and ~12 months (T3) after T1. In the ERP data, we isolated a reward positivity (RewP) and a late positive potential (LPP) via principal component analysis. We applied multilevel modeling to examine whether baseline ERPs interacted with Time in predicting disordered eating and whether these interactions varied by sex. RESULTS: We found a significant Time × LPP interaction in girls but not boys. Among girls, only those with a smaller LPP toward the losses (versus wins), which might reflect suboptimal evaluation and regulatory processes in undesired situations, showed increases in disordered eating from T1 to T3. DISCUSSION: We provided preliminary yet novel evidence concerning the prospective associations between reward processing and changes of disordered eating in early adolescents. Future studies along this line will be critical for understanding the early mechanisms of eating pathology, identifying youths at risk, and developing prevention strategies.

Reward positivity moderates the association between pubertal status and social anxiety symptoms in nine-to-12-year-old youths.

The transition to adolescence is characterized by rapid development of puberty, reward processing, and internalizing psychopathology (i.e., depression and anxiety). More advanced pubertal status and altered reward processing are both known to be associated with elevated internalizing symptoms. However, it was unclear to what extent pubertal status and reward processing interacted with each other in predicting internalizing psychopathology. We examined how the puberty-psychopathology association was moderated by the reward processing indexed by ERPs, including the reward positivity (RewP) and the late positive potential (LPP). A-hundred-and-fifteen nine-to-12-year-old typically developing youths (66 girls; Mean age/SD =10.98/1.18 years) reported their pubertal status and symptoms of depression and social anxiety and completed an EEG Doors task that assessed monetary reward feedback processing. A principal component analysis of the ERP data identified a RewP, an anterior LPP, and a posterior LPP, elicited by the win and loss feedback of the task. The puberty-social anxiety relationship was moderated by the RewP, an identified neural marker of reward sensitivity. Specifically, more advanced puberty was associated with heightened social anxiety symptoms in the presence of a larger, but not smaller, RewP. We did not observe any moderating effect of the LPPs. Our study provided novel evidence that a hypersensitivity toward the reward stimuli (indexed by an enlarged RewP) further exacerbated the risks associated with more advanced pubertal status for social anxiety.

Trial-level ERPs predicted behavioral responses during self-referential processing in late childhood.

Self-referential information is uniquely salient and preferentially processed even in children. The literature has used the self-referent encoding task (SRET) combined with event-related potentials (ERPs) to study self-referential processing and its associations with youth psychopathology. However, it is unclear how the ERP and behavioral indices of SRET are associated with each other, although this knowledge can promote our mechanistic understanding of this construct and its role in psychopathology. We examined this question in 115 9- to 12-year-old children, a critical period for the development of self-related concepts. By applying a multilevel modeling approach to the trial-level data of SRET, we disaggregated the between- and within-person variability and observed within-person, but not between-person, effects of the P2 and late positive potential (LPP) on behavioral responses: a larger P2 on a given trial predicted a faster response in this trial; a larger LPP on a given trial predicted a higher likelihood of endorsing the word of this trial. We provided novel evidence on how the within-person variability of the ERPs predicted the overt responses of the SRET in children. These findings inform our mechanistic knowledge of self-referential processing and shed light on a better understanding of the role of self-referential processing in the development of psychopathology.

Incremental validity of ERP correlates of self-referential processing in predicting emerging depressive symptoms in late childhood: Evidence from a community-dwelling sample.

Depressogenic self-referential processing (e.g., self-schemas reflecting shallower processing of positive, and deeper processing of negative, self-descriptive words) is an established cognitive vulnerability to depression. Alterations of event-related potentials (ERPs) during self-referential processing have been observed in adolescents with depression risk or clinical depression. However, no study has examined ERPs associated with self-referential processing in typical-risk youth with emerging depressive symptoms during late childhood, a high-risk period for depression. It is also unclear to what extent ERPs provide incremental validity in predicting symptoms beyond performance on self-referential processing tasks. Sixty-five community-dwelling children (38 girls; mean age/SD = 11.02/1.59 years) completed a self-referent encoding task (SRET) with EEG recorded. Children showed a larger P2 and a larger late positive potential (LPP) in response to positive SRET stimuli versus negative stimuli. Hierarchical regression showed that in the positive condition only, including ERP correlates (P1, P2, LPP) and interactions between the ERPs and positive SRET score increased the explained variation in depressive symptoms beyond behavioral SRET performance. The LPP in response to positive words was associated with lower depressive symptoms. The P1 and P2 in response to positive words interacted with positive SRET score, such that the association between positive SRET score and symptoms was significant in children with greater P1 but smaller P2. We provide novel evidence supporting the incremental validity of ERPs beyond behavioral makers in predicting emerging depressive symptoms in children. Our findings also highlight the moderating role of ERP activity in strengthening the association between behavioral markers of self-schemas and depressive outcomes.

Beyond the RewP: The reward feedback-elicited LPP and its potential associations with perceived stress and internalizing symptoms in late childhood.

Internalizing problems increase substantially during late childhood and early adolescence, which are known to be associated with elevated perceived stress as children transition into adolescence. One risk factor that may moderate the stress-symptom association is reward processing. While neurophysiological research in this field has focused on the reward positivity component (RewP) elicited during reward processing, little work has examined the reward feedback-elicited late positive potential (LPP) and its association with internalizing psychopathology. The present study examined the moderating roles of the RewP and feedback-elicited LPP in the relationship between perceived stress and internalizing symptoms in late childhood. A community sample of 115 nine-to-12-year-old children (66 girls, Mean age = 11.00 years, SD = 1.16) completed an EEG version of the reward feedback paradigm, the Doors task, and completed questionnaires on perceived stress and internalizing symptoms. A principal component analysis revealed three temporo-spatial factors that were temporally and spatially analogous to the RewP, anterior LPP, and posterior LPP, respectively. As expected, an enlarged RewP was found towards the win condition compared to the loss condition. We also observed a potentiated LPP towards loss relative to win feedback, which may reflect the evaluation and reappraisal processes following unsuccessful performance (i.e., loss). We did not, however, find significant moderating effects of any ERP components on the stress-symptom association. Our study was first to isolate the feedback-elicited LPP in a reward processing paradigm in children and provide initial evidence on the modulation of the ERP component by task conditions. Future research is warranted to further explore the functional significance of the reward feedback-elicited LPP in association with perceived stress and internalizing psychopathology in youths.

Behavioral and ERP indices of self-schematic processing show differential associations with emerging symptoms of depression and social anxiety in late childhood: Evidence from a community-dwelling sample.

Symptoms of depression and social anxiety elevate in late childhood. An identified cognitive risk to both depression and social anxiety is maladaptive self-schemas (or self-schematic processing). Beyond the behavioral indices of this construct, event-related potentials (ERPs) during self-schematic processing have also been observed to be associated with depression or depressive symptoms. However, no study has examined the ERPs underlying self-schematic processing in relation to social anxiety. More importantly, it was unclear to what extent behavioral and ERP indices of self-schematic processing were differentially associated with depression and social anxiety, especially in typical-risk youth with emerging symptoms. A hundred and fifteen community-dwelling children (66 girls; Mean age=10.91 years, SD=1.45) completed a self-referent encoding task (SRET) with EEG recorded. A Principal Component Analysis identified a late positive potential (LPP) component elicited in both the positive and negative SRET conditions. Multivariate multiple regression showed that in both conditions, behavioral SRET scores were associated with depressive symptoms while partialling out social anxiety symptoms, but not with social anxiety symptoms with depressive symptoms partialled out. The LPP amplitude elicited in both conditions showed marginally positive associations with social anxiety symptoms while partialling out depressive symptoms, but not with depressive symptoms while accounting for social anxiety. This study provides novel evidence concerning the ERP correlates of self-schematic processing in relation to social anxiety symptoms. More importantly, our findings for the first time speak to the differential associations between the behavioral SRET scores and SRET-elicited LPP and emerging symptoms of depression and social anxiety in late childhood.

Goal adjustment capacities in uncontrollable life circumstances: Benefits for psychological well-being during COVID-19.

Goal adjustment capacities (i.e., goal disengagement and goal reengagement) are core self-regulatory resources theorized to buffer psychological well-being during intractable life circumstances. However, research has yet to examine whether these capacities protect well-being for individuals who encounter uncontrollable losses in their ability to pursue important life goals due to the COVID-19 pandemic. Using a nationally-representative sample of U.S. adults aged 18-80 (n = 292), the present longitudinal study examined the extent to which goal disengagement and reengagement predicted levels and change in psychological well-being for individuals who differed in perceived control over their goals early in the pandemic. Results from multilevel growth models showed that goal reengagement, but not goal disengagement, capacities predicted higher levels of well-being during the pandemic (lower perceived stress, depressive symptoms; higher life satisfaction, meaning in life). Moderation models showed the benefits of goal reengagement for well-being were pronounced among individuals who perceived pandemic-induced declines in control over their goals. Findings inform theories of motivation and self-regulation and point to the adaptive value of goal reengagement capacities during uncontrollable life circumstances.