Phytocompounds from Amazonian Plant Species against Acute Kidney Injury: Potential Nephroprotective Effects.

There are several Amazonian plant species with potential pharmacological validation for the treatment of acute kidney injury, a condition in which the kidneys are unable to adequately filter the blood, resulting in the accumulation of toxins and waste in the body. Scientific production on plant compounds capable of preventing or attenuating acute kidney injury-caused by several factors, including ischemia, toxins, and inflammation-has shown promising results in animal models of acute kidney injury and some preliminary studies in humans. Despite the popular use of Amazonian plant species for kidney disorders, further pharmacological studies are needed to identify active compounds and subsequently conduct more complex preclinical trials. This article is a brief review of phytocompounds with potential nephroprotective effects against acute kidney injury (AKI). The classes of Amazonian plant compounds with significant biological activity most evident in the consulted literature were alkaloids, flavonoids, tannins, steroids, and terpenoids. An expressive phytochemical and pharmacological relevance of the studied species was identified, although with insufficiently explored potential, mainly in the face of AKI, a clinical condition with high morbidity and mortality.

Metalobezoar intestinal: relato de caso / Metalobezoar bowel; case report

Objetivo: relatar um caso de metalobezoar intestinal. Relato de caso: paciente de 18 anos atendido no Serviço de Cirurgia Geral do Hospital de Emergências de Macapá-AP, com quadro de dor abdominal, vômitos e febre. Radiografia simples de abdome apresentando imagem radiopaca em quadrante inferior direito. Considerações Finais: confirmado diagnóstico de metalobezoar após abordagem cirúrgica por laparotomia exploratória, salientando a necessidade de, diante de um abdome agudo inflamatório, sempre ter em mente as causas comuns de sua ocorrência, mas também orientar a propedêutica e o diagnóstico diferencial para causas incomuns.

Objective: to report a case of intestinal metalobezoar. Case report: 18 year old patient attended at the General Surgery Service of the Emergency Hospital in Macapa-AP, with abdominal pain, vomiting and fever. Plain abdominal radiograph showing radiopaque image in the lower right quadrant. Final considerations: Confirmed diagnosis of metalobezoar after surgical exploratory laparotomy approach, stressing the need for, in a case of inflammatory acute abdomen, to always keep in mind the common causes of their occurrence, but also guide the propaedeutics and differential diagnosis for unusual causes.