RESUMEN
OBJECTIVE: To evaluate the effects of Behçet's syndrome (BS) on tear osmolarity and tear film function tests. METHODS: Thirty patients with BS and 41 control subjects were enrolled in this study. Tear osmolarity was measured with an osmometer. Tear film function tests involved corneal fluorescein staining, tear film breakup time (TBUT), Schirmer's 1 test, and an Ocular Surface Disease Index (OSDI) Questionnaire. RESULTS: The patients with BS had significantly higher tear osmolarity (p = 0.000) and OSDI scores (p = 0.000) than the healthy controls. The TBUT (p = 0.000) and Schirmer's 1 test (p = 0.033) results were significantly lower in the BS group, but the fluorescein staining results were not statistically different. A significant correlation was found between tear osmolarity, OSDI, and the activity of BS. CONCLUSIONS: BS is associated with hyperosmolarity of the tear film, which can damage the ocular surface and affect tear functions.
Asunto(s)
Síndrome de Behçet/metabolismo , Síndromes de Ojo Seco/metabolismo , Lágrimas/metabolismo , Adulto , Síndrome de Behçet/complicaciones , Estudios de Casos y Controles , Síndromes de Ojo Seco/etiología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Concentración Osmolar , Estudios Prospectivos , Adulto JovenRESUMEN
PURPOSE: To evaluate the effect of rheumatoid arthritis (RA) on choroid, retinal nerve fiber layer (RNFL), and foveal thickness using spectral domain optical coherence tomography (OCT). METHODS: Fifty patients with RA and forty-one healthy volunteers were enrolled in this study. The subfoveal, perifoveal choroidal, RNFL, and foveal thicknesses were measured by spectral domain OCT. RESULTS: The mean subfoveal, nasal, and temporal choroidal thicknesses in RA individuals were significantly higher than those in the control group (p Ë 0.05). However, there was no significant difference between the RA and healthy group regarding RNFL and foveal thickness (p Ë 0.05). A significant correlation was found between rheumatoid factor (RF) and the subfoveal temporal choroidal thickness. CONCLUSION: Choroidal thickness in RA patients was higher than that in healthy participants. Choroidal thickening showed a positive correlation with RF, which may be an indicator for systemic vasculitis.