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1.

Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo.

Nilles, Julie; Theile, Dirk; Weiss, Johanna; Haefeli, Walter E; Ruez, Stephanie.

Arch Toxicol; 2024 May 07.

Artículo en Inglés | MEDLINE | ID: mdl-38713375

2.

Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site.

Phondeth, Lottida; Kamaraj, Rajamanikkam; Nilles, Julie; Weiss, Johanna; Haefeli, Walter E; Pávek, Petr; Theile, Dirk.

Arch Toxicol; 98(1): 223-231, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-37833491

3.

Molecular prediction of clinical response to anti-PD-1/anti-PD-L1 immune checkpoint inhibitors: New perspectives for precision medicine and mass spectrometry-based investigations.

Longuespée, Rémi; Theile, Dirk; Zörnig, Inka; Hassel, Jessica C; Lindner, Joshua Raoul; Haefeli, Walter E; Fresnais, Margaux.

Int J Cancer; 153(2): 252-264, 2023 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-36408912

4.

Comprehensive in vitro analysis evaluating the variable drug-drug interaction risk of rifampicin compared to rifabutin.

Nilles, Julie; Weiss, Johanna; Sauter, Max; Haefeli, Walter E; Ruez, Stephanie; Theile, Dirk.

Arch Toxicol; 97(8): 2219-2230, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37285043

5.

How to avoid misinterpretation of dual reporter gene assay data affected by cell damage.

Nilles, Julie; Weiss, Johanna; Haefeli, Walter E; Ruez, Stephanie; Theile, Dirk.

Arch Toxicol; 96(9): 2501-2510, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35678845

6.

A nuclear factor kappa B reporter cell line used to evaluate ex vivo the net inflammatory effect of plasma samples from patients with rheumatoid arthritis, psoriasis, or COVID-19.

Wagner, Lelia; Haefeli, Walter E; Merle, Uta; Lorenz, Hanns-Martin; Hohmann, Nicolas; Weiss, Johanna; Theile, Dirk.

Cytokine; 138: 155399, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33338916

7.

Approaching sites of action of drugs in clinical pharmacology: New analytical options and their challenges.

Longuespée, Rémi; Theile, Dirk; Fresnais, Margaux; Burhenne, Jürgen; Weiss, Johanna; Haefeli, Walter E.

Br J Clin Pharmacol; 87(3): 858-874, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-32881012

8.

Reporter cell assay-based functional quantification of TNF-α-antagonists in serum - a proof-of-principle study for adalimumab.

Schuster, Lukas; Sauter, Max; Uhl, Philipp; Meid, Andreas; Haefeli, Walter E; Weiss, Johanna; Theile, Dirk.

Anal Biochem; 596: 113646, 2020 05 01.

Artículo en Inglés | MEDLINE | ID: mdl-32112722

9.

Methadone against cancer: Lost in translation.

Theile, Dirk; Mikus, Gerd.

Int J Cancer; 143(8): 1840-1848, 2018 10 15.

Artículo en Inglés | MEDLINE | ID: mdl-29516505

10.

Physiology-based pharmacokinetic modelling and experimental data suggest that rifabutin alters dolutegravir kinetics by both P-glycoprotein induction and concurrent inhibition.

Theile, Dirk; Nilles, Julie; Meid, Andreas D.

Br J Clin Pharmacol; 89(7): 2329-2331, 2023 07.

Artículo en Inglés | MEDLINE | ID: mdl-37077127

11.

Impact of enzalutamide and its main metabolite N-desmethyl enzalutamide on pharmacokinetically important drug metabolizing enzymes and drug transporters.

Weiss, Johanna; Kocher, Jutta; Mueller, Corina; Rosenzweig, Stephanie; Theile, Dirk.

Biopharm Drug Dispos; 38(9): 517-525, 2017 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-28865089

12.

Under-Reported Aspects of Platinum Drug Pharmacology.

Theile, Dirk.

Molecules; 22(3)2017 Feb 28.

Artículo en Inglés | MEDLINE | ID: mdl-29760371

13.

Bortezomib and ixazomib protect firefly luciferase from degradation and can flaw respective reporter gene assays.

Becker, Jonas Philipp; Clemens, Jannick Robert; Theile, Dirk; Weiss, Johanna.

Anal Biochem; 509: 124-129, 2016 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-27325500

14.

Fetal calf sera can distort cell-based luminescent proteasome assays through heat-resistant chymotrypsin-like activity.

Dettmer, Susan; Theile, Dirk; Seckinger, Anja; Burhenne, Jürgen; Weiss, Johanna.

Anal Biochem; 471: 23-5, 2015 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-25447494

15.

Desmethyl bosentan displays a similar in vitro interaction profile as bosentan.

Weiss, Johanna; Baumann, Sybille; Theile, Dirk; Haefeli, Walter Emil.

Pulm Pharmacol Ther; 30: 80-6, 2015 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-25535031

16.

Bosentan enhances in vitro bortezomib's anti-proliferative potency against multiple myeloma by mechanisms going beyond endothelin receptor blockade.

Schäfer, Julia; Weiss, Johanna; Theile, Dirk.

Br J Haematol; 184(6): 1052-1055, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-29676451

17.

Given the Data of Hommers and Colleagues, Valproic Acid Is Not an Unequivocal Inducer of Clozapine Metabolism.

Foerster, Kathrin I; Theile, Dirk.

J Clin Psychopharmacol; 39(4): 419-420, 2019.

Artículo en Inglés | MEDLINE | ID: mdl-31188239

18.

RNA is a pro-apoptotic target of cisplatin in cancer cell lines and C. elegans.

Rose, Fabian; Köberle, Beate; Honnen, Sebastian; Bay, Cindy; Burhenne, Jürgen; Weiss, Johanna; Haefeli, Walter E; Theile, Dirk.

Biomed Pharmacother; 173: 116450, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38503239

19.

The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants.

Nilles, Julie; Weiss, Johanna; Masin, Martin; Tuffs, Christopher; Strowitzki, Moritz J; Haefeli, Walter E; Ruez, Stephanie; Theile, Dirk.

Naunyn Schmiedebergs Arch Pharmacol; 397(4): 2485-2496, 2024 04.

Artículo en Inglés | MEDLINE | ID: mdl-37851058

20.

Watch out for reporter gene assays with Renilla luciferase and paclitaxel.

Theile, Dirk; Spalwisz, Adriana; Weiss, Johanna.

Anal Biochem; 437(2): 109-10, 2013 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-23499973

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