Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879).

: An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1-3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima.

During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 µM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.

A brief study on the effects of storage conditions on sexual lubricant components in the presence of a biological fluid.

This study illustrated the effects of environmental conditions (i.e., temperature) on the components of a condom lubricant in the presence of vaginal secretion. Understanding the effects of storage is important for the short-term handling of sexual assault kits, that may contain post-coital swabs, prior to chemical analysis. This preliminary three-day investigation utilized gas chromatography-mass spectrometry (GC-MS) to analyze the samples at three timepoints (24, 48, and 72 h). Lubricated and non-lubricated swabs were exposed to five storage conditions. After percent recovery calculation, GC-MS interpretation, and statistical analysis, it was determined that storing swabs at room temperature (22 °C) for up to 72 h best maintained the integrity of the sexual lubricant - in comparison to T0 - as opposed to colder storage temperatures of 4 °C and - 20 °C. Despite the varying degree of changes in the storage conditions and temperatures, PDMS components were persistent in all lubricated samples and can be used to confirm the presence of condom lubricant if initially present in the sample.