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1.

SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.

Miyamoto, Takashi; Kim, Chaeyoung; Chow, Johann; Dugas, Jason C; DeGroot, Jack; Bagdasarian, Alex L; Thottumkara, Arun P; Larhammar, Martin; Calvert, Meredith Ek; Fox, Brian M; Lewcock, Joseph W; Kane, Lesley A.

J Biol Chem; 300(2): 105630, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38199568

2.

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Lee, Bianca J; Boyer, Jacob A; Burnett, G Leslie; Thottumkara, Arun P; Tibrewal, Nidhi; Wilson, Stacy L; Hsieh, Tientien; Marquez, Abby; Lorenzana, Edward G; Evans, James W; Hulea, Laura; Kiss, Gert; Liu, Hui; Lee, Dong; Larsson, Ola; McLaughlan, Shannon; Topisirovic, Ivan; Wang, Zhengping; Wang, Zhican; Zhao, Yongyuan; Wildes, David; Aggen, James B; Singh, Mallika; Gill, Adrian L; Smith, Jacqueline A M; Rosen, Neal.

Nat Chem Biol; 17(10): 1065-1074, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-34168367

3.

Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Lee, Bianca J; Boyer, Jacob A; Burnett, G Leslie; Thottumkara, Arun P; Tibrewal, Nidhi; Wilson, Stacy L; Hsieh, Tientien; Marquez, Abby; Lorenzana, Edward G; Evans, James W; Hulea, Laura; Kiss, Gert; Liu, Hui; Lee, Dong; Larsson, Ola; McLaughlan, Shannon; Topisirovic, Ivan; Wang, Zhengping; Wang, Zhican; Zhao, Yongyuan; Wildes, David; Aggen, James B; Singh, Mallika; Gill, Adrian L; Smith, Jacqueline A M; Rosen, Neal.

Nat Chem Biol; 17(8): 925, 2021 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-34188221

4.

Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Lee, Bianca J; Boyer, Jacob A; Burnett, G Leslie; Thottumkara, Arun P; Tibrewal, Nidhi; Wilson, Stacy L; Hsieh, Tientien; Marquez, Abby; Lorenzana, Edward G; Evans, James W; Hulea, Laura; Kiss, Gert; Liu, Hui; Lee, Dong; Larsson, Ola; McLaughlan, Shannon; Topisirovic, Ivan; Wang, Zhengping; Wang, Zhican; Zhao, Yongyuan; Wildes, David; Aggen, James B; Singh, Mallika; Gill, Adrian L; Smith, Jacqueline A M; Rosen, Neal.

Nat Chem Biol; 17(11): 1209, 2021 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-34616097

5.

Saxitoxin.

Thottumkara, Arun P; Parsons, William H; Du Bois, J.

Angew Chem Int Ed Engl; 53(23): 5760-84, 2014 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-24771635

6.

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.

Burnett, G Leslie; Yang, Yu C; Aggen, James B; Pitzen, Jennifer; Gliedt, Micah K; Semko, Chris M; Marquez, Abby; Evans, James W; Wang, Gang; Won, Walter S; Tomlinson, Aidan C A; Kiss, Gert; Tzitzilonis, Christos; Thottumkara, Arun P; Cregg, James; Mellem, Kevin T; Choi, Jong S; Lee, Julie C; Zhao, Yongyuan; Lee, Bianca J; Meyerowitz, Justin G; Knox, John E; Jiang, Jingjing; Wang, Zhican; Wildes, David; Wang, Zhengping; Singh, Mallika; Smith, Jacqueline A M; Gill, Adrian L.

J Med Chem; 66(1): 149-169, 2023 01 12.

Artículo en Inglés | MEDLINE | ID: mdl-36533617

7.

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.

Craig, Robert A; Fox, Brian M; Hu, Cheng; Lexa, Katrina W; Osipov, Maksim; Thottumkara, Arun P; Larhammar, Martin; Miyamoto, Takashi; Rana, Anil; Kane, Lesley A; Yulyaningsih, Ernie; Solanoy, Hilda; Nguyen, Hoang; Chau, Roni; Earr, Timothy; Kajiwara, Yuji; Fleck, Daniel; Lucas, Anthony; Haddick, Patrick C G; Takahashi, Ryan H; Tong, Vincent; Wang, Jing; Canet, Mark J; Poda, Suresh B; Scearce-Levie, Kimberly; Srivastava, Ankita; Sweeney, Zachary K; Xu, Musheng; Zhang, Rui; He, Jianrong; Lei, Yanan; Zhuo, Zheng; de Vicente, Javier.

J Med Chem; 65(24): 16290-16312, 2022 12 22.

Artículo en Inglés | MEDLINE | ID: mdl-36469401

8.

In situ generation of o-iodoxybenzoic acid (IBX) and the catalytic use of it in oxidation reactions in the presence of Oxone as a co-oxidant.

Thottumkara, Arun P; Bowsher, Michael S; Vinod, Thottumkara K.

Org Lett; 7(14): 2933-6, 2005 Jul 07.

Artículo en Inglés | MEDLINE | ID: mdl-15987173

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SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Saxitoxin.

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.

In situ generation of o-iodoxybenzoic acid (IBX) and the catalytic use of it in oxidation reactions in the presence of Oxone as a co-oxidant.