Detalles de la búsqueda
1.
Neonatal exposure to sevoflurane induces adolescent neurobehavioral dysfunction by interfering with hippocampal glycerophoslipid metabolism in rats.
Cereb Cortex;
33(5): 1955-1971, 2023 02 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35584785
2.
Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53.
Molecules;
29(3)2024 Feb 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38338471
3.
Engeletin alleviates depression-like phenotype by increasing synaptic plasticity via the BDNF-TrkB-mTORC1 signalling pathway.
J Cell Mol Med;
27(23): 3928-3938, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37799103
4.
Integrated lipidomic and transcriptomic analysis reveals clarithromycin-induced alteration of glycerophospholipid metabolism in the cerebral cortex of mice.
Cell Biol Toxicol;
39(3): 771-793, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34458952
5.
Design, synthesis, and biological evaluation of novel molecules as potent inhibitors of PLK1.
Bioorg Chem;
139: 106711, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37473479
6.
Study on Pharmacokinetics and Metabolic Profiles of Novel Potential PLK-1 Inhibitors by UHPLC-MS/MS Combined with UHPLC-Q-Orbitrap/HRMS.
Molecules;
28(6)2023 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36985522
7.
4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis.
J Neurosci;
41(31): 6753-6774, 2021 08 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34099513
8.
Efficacy, Safety, and Tolerability of Ansofaxine (LY03005) Extended-Release Tablet for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding, Phase 2 Clinical Trial.
Int J Neuropsychopharmacol;
25(3): 252-260, 2022 03 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34747448
9.
A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis.
Pharmacol Res;
177: 106128, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35150860
10.
mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens.
Acta Pharmacol Sin;
43(2): 295-306, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34522005
11.
The tyrosine kinase inhibitor LPM4870108 impairs learning and memory and induces transcriptomic and genespecific DNA methylation changes in rats.
Arch Toxicol;
96(3): 845-857, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35098321
12.
PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model.
Toxicol Appl Pharmacol;
429: 115698, 2021 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34428447
13.
Assessment of the toxicity and toxicokinetics of the novel potent tropomyosin receptor kinase (Trk) inhibitor LPM4870108 in rhesus monkeys.
Regul Toxicol Pharmacol;
122: 104886, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33556418
14.
Pharmacokinetics of S-epacadostat, an indoleamine 2,3-dioxygenase 1 inhibitor, in dog plasma and identification of its metabolites in vivo and in vitro.
Biomed Chromatogr;
35(12): e5226, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34388261
15.
WITHDRAWN: PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor coordination-associated side effects in neuropathic pain model.
Toxicol Appl Pharmacol;
: 115208, 2020 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32828906
16.
PCC0208023, a potent SHP2 allosteric inhibitor, imparts an antitumor effect against KRAS mutant colorectal cancer.
Toxicol Appl Pharmacol;
398: 115019, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32335126
17.
Role of BRD4 phosphorylation in the nucleus accumbens in relapse to cocaine-seeking behavior in mice.
Addict Biol;
25(5): e12808, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31364211
18.
Toxicological evaluation of, red rice yeast extract, Xuezhikang: Acute, 26-week chronic and genotoxicity studies.
Regul Toxicol Pharmacol;
114: 104654, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-32278069
19.
A 26-week toxicological study of Xuezhikang (XZK), red yeast rice extract, in Beagle dogs with a 4-week recovery period.
Regul Toxicol Pharmacol;
117: 104781, 2020 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-32896614
20.
A 26-week 20(S)-ginsenoside Rg3 oral toxicity study in Beagle dogs.
Regul Toxicol Pharmacol;
110: 104522, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-31726191