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1.

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Khera, Amit V; Chaffin, Mark; Wade, Kaitlin H; Zahid, Sohail; Brancale, Joseph; Xia, Rui; Distefano, Marina; Senol-Cosar, Ozlem; Haas, Mary E; Bick, Alexander; Aragam, Krishna G; Lander, Eric S; Smith, George Davey; Mason-Suares, Heather; Fornage, Myriam; Lebo, Matthew; Timpson, Nicholas J; Kaplan, Lee M; Kathiresan, Sekar.

Cell; 177(3): 587-596.e9, 2019 04 18.

Artículo en Inglés | MEDLINE | ID: mdl-31002795

2.

Variation in ERAP2 has opposing effects on severe respiratory infection and autoimmune disease.

Hamilton, Fergus; Mentzer, Alexander J; Parks, Tom; Baillie, J Kenneth; Smith, George Davey; Ghazal, Peter; Timpson, Nicholas J.

Am J Hum Genet; 110(4): 691-702, 2023 04 06.

Artículo en Inglés | MEDLINE | ID: mdl-36889308

3.

The UK Biobank: A Shining Example of Genome-Wide Association Study Science with the Power to Detect the Murky Complications of Real-World Epidemiology.

Tan, Vanessa Y; Timpson, Nicholas J.

Annu Rev Genomics Hum Genet; 23: 569-589, 2022 08 31.

Artículo en Inglés | MEDLINE | ID: mdl-35508184

4.

A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis.

Constantinescu, Andrei-Emil; Hughes, David A; Bull, Caroline J; Fleming, Kathryn; Mitchell, Ruth E; Zheng, Jie; Kar, Siddhartha; Timpson, Nicholas J; Amulic, Borko; Vincent, Emma E.

Hum Genomics; 18(1): 26, 2024 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-38491524

5.

An early look at birth cohort genetics in China.

Timpson, Nicholas John.

Nature; 626(7999): 487-488, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38297045

6.

The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT).

Corbin, Laura J; Hughes, David A; Bull, Caroline J; Vincent, Emma E; Smith, Madeleine L; McConnachie, Alex; Messow, Claudia-Martina; Welsh, Paul; Taylor, Roy; Lean, Michael E J; Sattar, Naveed; Timpson, Nicholas J.

Diabetologia; 67(1): 74-87, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-37878066

7.

Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomisation study.

Constantinescu, Andrei-Emil; Bull, Caroline J; Jones, Nicholas; Mitchell, Ruth; Burrows, Kimberley; Dimou, Niki; Bézieau, Stéphane; Brenner, Hermann; Buchanan, Daniel D; D'Amato, Mauro; Jenkins, Mark A; Moreno, Victor; Pai, Rish K; Um, Caroline Y; White, Emily; Murphy, Neil; Gunter, Marc; Timpson, Nicholas J; Huyghe, Jeroen R; Vincent, Emma E.

Int J Cancer; 154(1): 94-103, 2024 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-37578112

8.

Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function.

Corbin, Laura J; White, Stephen J; Taylor, Amy E; Williams, Christopher M; Taylor, Kurt; van den Bosch, Marion T; Teasdale, Jack E; Jones, Matthew; Bond, Mark; Harper, Matthew T; Falk, Louise; Groom, Alix; Hazell, Georgina G J; Paternoster, Lavinia; Munafò, Marcus R; Nordestgaard, Børge G; Tybjærg-Hansen, Anne; Bojesen, Stig E; Relton, Caroline; Min, Josine L; Davey Smith, George; Mumford, Andrew D; Poole, Alastair W; Timpson, Nicholas J.

Circ Res; 130(3): 384-400, 2022 02 04.

Artículo en Inglés | MEDLINE | ID: mdl-35012325

9.

Genetic architecture: the shape of the genetic contribution to human traits and disease.

Timpson, Nicholas J; Greenwood, Celia M T; Soranzo, Nicole; Lawson, Daniel J; Richards, J Brent.

Nat Rev Genet; 19(2): 110-124, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29225335

10.

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study.

Hamilton, Fergus W; Thomas, Matt; Arnold, David; Palmer, Tom; Moran, Ed; Mentzer, Alexander J; Maskell, Nick; Baillie, Kenneth; Summers, Charlotte; Hingorani, Aroon; MacGowan, Alasdair; Khandaker, Golam M; Mitchell, Ruth; Davey Smith, George; Ghazal, Peter; Timpson, Nicholas J.

PLoS Med; 20(1): e1004174, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36716318

11.

Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci.

Manousaki, Despoina; Mitchell, Ruth; Dudding, Tom; Haworth, Simon; Harroud, Adil; Forgetta, Vincenzo; Shah, Rupal L; Luan, Jian'an; Langenberg, Claudia; Timpson, Nicholas J; Richards, J Brent.

Am J Hum Genet; 106(3): 327-337, 2020 03 05.

Artículo en Inglés | MEDLINE | ID: mdl-32059762

12.

Voluntary risk mitigation behaviour can reduce impact of SARS-CoV-2: a real-time modelling study of the January 2022 Omicron wave in England.

Brooks-Pollock, Ellen; Northstone, Kate; Pellis, Lorenzo; Scarabel, Francesca; Thomas, Amy; Nixon, Emily; Matthews, David A; Bowyer, Vicky; Garcia, Maria Paz; Steves, Claire J; Timpson, Nicholas J; Danon, Leon.

BMC Med; 21(1): 25, 2023 01 19.

Artículo en Inglés | MEDLINE | ID: mdl-36658548

13.

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.

Papadimitriou, Nikos; Bull, Caroline J; Jenab, Mazda; Hughes, David J; Bell, Joshua A; Sanderson, Eleanor; Timpson, Nicholas J; Smith, George Davey; Albanes, Demetrius; Campbell, Peter T; Küry, Sébastien; Le Marchand, Loic; Ulrich, Cornelia M; Visvanathan, Kala; Figueiredo, Jane C; Newcomb, Polly A; Pai, Rish K; Peters, Ulrike; Tsilidis, Kostas K; Boer, Jolanda M A; Vincent, Emma E; Mariosa, Daniela; Gunter, Marc J; Richardson, Tom G; Murphy, Neil.

BMC Med; 21(1): 5, 2023 01 04.

Artículo en Inglés | MEDLINE | ID: mdl-36600297

14.

metaboprep: an R package for preanalysis data description and processing.

Hughes, David A; Taylor, Kurt; McBride, Nancy; Lee, Matthew A; Mason, Dan; Lawlor, Deborah A; Timpson, Nicholas J; Corbin, Laura J.

Bioinformatics; 38(7): 1980-1987, 2022 03 28.

Artículo en Inglés | MEDLINE | ID: mdl-35134881

15.

A framework for research into continental ancestry groups of the UK Biobank.

Constantinescu, Andrei-Emil; Mitchell, Ruth E; Zheng, Jie; Bull, Caroline J; Timpson, Nicholas J; Amulic, Borko; Vincent, Emma E; Hughes, David A.

Hum Genomics; 16(1): 3, 2022 01 29.

Artículo en Inglés | MEDLINE | ID: mdl-35093177

16.

Characterising patterns of COVID-19 and long COVID symptoms: evidence from nine UK longitudinal studies.

Bowyer, Ruth C E; Huggins, Charlotte; Toms, Renin; Shaw, Richard J; Hou, Bo; Thompson, Ellen J; Kwong, Alex S F; Williams, Dylan M; Kibble, Milla; Ploubidis, George B; Timpson, Nicholas J; Sterne, Jonathan A C; Chaturvedi, Nishi; Steves, Claire J; Tilling, Kate; Silverwood, Richard J.

Eur J Epidemiol; 38(2): 199-210, 2023 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-36680646

17.

Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies.

Beaumont, Robin N; Kotecha, Sarah J; Wood, Andrew R; Knight, Bridget A; Sebert, Sylvain; McCarthy, Mark I; Hattersley, Andrew T; Järvelin, Marjo-Riitta; Timpson, Nicholas J; Freathy, Rachel M; Kotecha, Sailesh.

PLoS Genet; 16(12): e1009191, 2020 12.

Artículo en Inglés | MEDLINE | ID: mdl-33284794

18.

Common variation at 16p11.2 is associated with glycosuria in pregnancy: findings from a genome-wide association study in European women.

Lee, Matthew A; McMahon, George; Karhunen, Ville; Wade, Kaitlin H; Corbin, Laura J; Hughes, David A; Smith, George Davey; Lawlor, Debbie A; Jarvelin, Marjo-Riitta; Timpson, Nicholas J.

Hum Mol Genet; 29(12): 2098-2106, 2020 07 29.

Artículo en Inglés | MEDLINE | ID: mdl-32227112

19.

HMOX1 STR polymorphism and malaria: an analysis of a large clinical dataset.

Hamilton, Fergus; Mitchell, Ruth; Cunnington, Aubrey; Ghazal, Peter; Timpson, Nicholas J.

Malar J; 21(1): 342, 2022 Nov 17.

Artículo en Inglés | MEDLINE | ID: mdl-36397106

20.

Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis.

Goudswaard, Lucy J; Corbin, Laura J; Burley, Kate L; Mumford, Andrew; Akbari, Parsa; Soranzo, Nicole; Butterworth, Adam S; Watkins, Nicholas A; Pournaras, Dimitri J; Harris, Jessica; Timpson, Nicholas J; Hers, Ingeborg.

Platelets; 33(6): 869-878, 2022 Aug 18.

Artículo en Inglés | MEDLINE | ID: mdl-35068290

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