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1.

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.

Kumagai, Shogo; Togashi, Yosuke; Kamada, Takahiro; Sugiyama, Eri; Nishinakamura, Hitomi; Takeuchi, Yoshiko; Vitaly, Kochin; Itahashi, Kota; Maeda, Yuka; Matsui, Shigeyuki; Shibahara, Takuma; Yamashita, Yasuho; Irie, Takuma; Tsuge, Ayaka; Fukuoka, Shota; Kawazoe, Akihito; Udagawa, Hibiki; Kirita, Keisuke; Aokage, Keiju; Ishii, Genichiro; Kuwata, Takeshi; Nakama, Kenta; Kawazu, Masahito; Ueno, Toshihide; Yamazaki, Naoya; Goto, Koichi; Tsuboi, Masahiro; Mano, Hiroyuki; Doi, Toshihiko; Shitara, Kohei; Nishikawa, Hiroyoshi.

Nat Immunol; 21(11): 1346-1358, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32868929

2.

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells.

Kumagai, Shogo; Togashi, Yosuke; Sakai, Chika; Kawazoe, Akihito; Kawazu, Masahito; Ueno, Toshihide; Sato, Eiichi; Kuwata, Takeshi; Kinoshita, Takahiro; Yamamoto, Masami; Nomura, Sachiyo; Tsukamoto, Tetsuya; Mano, Hiroyuki; Shitara, Kohei; Nishikawa, Hiroyoshi.

Immunity; 53(1): 187-203.e8, 2020 07 14.

Artículo en Inglés | MEDLINE | ID: mdl-32640259

3.

Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.

Arakawa, Ayumu; Ichikawa, Hitoshi; Kubo, Takashi; Motoi, Noriko; Kumamoto, Tadashi; Nakajima, Miho; Yonemori, Kan; Noguchi, Emi; Sunami, Kuniko; Shiraishi, Kouya; Kakishima, Hiroki; Yoshida, Hiroshi; Hishiki, Tomoro; Kawakubo, Naonori; Kuroda, Takafumi; Kiyokawa, Takako; Yamada, Kyosuke; Yanaihara, Nozomu; Takahashi, Kazuaki; Okamoto, Aikou; Hirabayashi, Shinsuke; Hasegawa, Daisuke; Manabe, Atsushi; Ono, Kentaro; Matsuoka, Masaki; Arai, Yasuhito; Togashi, Yosuke; Shibata, Tatsuhiro; Nishikawa, Hiroyoshi; Aoki, Kazunori; Yamamoto, Noboru; Kohno, Takashi; Ogawa, Chitose.

N Engl J Med; 384(1): 42-50, 2021 01 07.

Artículo en Inglés | MEDLINE | ID: mdl-33406329

4.

Suppression from beyond the grave.

Togashi, Yosuke; Nishikawa, Hiroyoshi.

Nat Immunol; 18(12): 1285-1286, 2017 11 16.

Artículo en Inglés | MEDLINE | ID: mdl-29144496

5.

Activated CTLA-4-independent immunosuppression of Treg cells disturbs CTLA-4 blockade-mediated antitumor immunity.

Watanabe, Tomofumi; Ishino, Takamasa; Ueda, Youki; Nagasaki, Joji; Sadahira, Takuya; Dansako, Hiromichi; Araki, Motoo; Togashi, Yosuke.

Cancer Sci; 114(5): 1859-1870, 2023 May.

Artículo en Inglés | MEDLINE | ID: mdl-36762794

6.

Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models.

Kemmotsu, Naoya; Zhu, Li; Nagasaki, Joji; Otani, Yoshihiro; Ueda, Youki; Dansako, Hiromichi; Fang, Yue; Date, Isao; Togashi, Yosuke.

Cancer Sci; 114(10): 3848-3856, 2023 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-37485636

7.

Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.

Ishino, Takamasa; Kawashima, Shusuke; Tanji, Etsuko; Ueno, Toshihide; Ueda, Youki; Ogasawara, Sadahisa; Sato, Kazuhito; Mano, Hiroyuki; Ishihara, Soichiro; Kato, Naoya; Kawazu, Masahito; Togashi, Yosuke.

Br J Cancer; 128(6): 1166-1175, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-36732592

8.

HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability.

Kawazu, Masahito; Ueno, Toshihide; Saeki, Koichi; Sax, Nicolas; Togashi, Yosuke; Kanaseki, Takayuki; Chida, Keigo; Kishigami, Fumishi; Sato, Kazuhito; Kojima, Shinya; Otsuka, Masafumi; Kawazoe, Akihito; Nishinakamura, Hitomi; Yuka, Maeda; Yamamoto, Yoko; Yamashita, Kazuo; Inoue, Satoshi; Tanegashima, Tokiyoshi; Matsubara, Daisuke; Tane, Kenta; Tanaka, Yosuke; Iinuma, Hisae; Hashiguchi, Yojiro; Hazama, Shoichi; Khor, Seik-Soon; Tokunaga, Katsushi; Tsuboi, Masahiro; Niki, Toshiro; Eto, Masatoshi; Shitara, Kohei; Torigoe, Toshihiko; Ishihara, Soichiro; Aburatani, Hiroyuki; Haeno, Hiroshi; Nishikawa, Hiroyoshi; Mano, Hiroyuki.

Gastroenterology; 162(3): 799-812, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-34687740

9.

Resistance to immune checkpoint inhibitors and the tumor microenvironment.

Kawashima, Shusuke; Togashi, Yosuke.

Exp Dermatol; 32(3): 240-249, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36437644

10.

A variety of 'exhausted' T cells in the tumor microenvironment.

Nagasaki, Joji; Togashi, Yosuke.

Int Immunol; 34(11): 563-570, 2022 10 05.

Artículo en Inglés | MEDLINE | ID: mdl-35460561

11.

Mechanisms of resistance to immune checkpoint inhibitors.

Nagasaki, Joji; Ishino, Takamasa; Togashi, Yosuke.

Cancer Sci; 113(10): 3303-3312, 2022 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-35848888

12.

Aging, cancer, and antitumor immunity.

Ikeda, Hideki; Togashi, Yosuke.

Int J Clin Oncol; 27(2): 316-322, 2022 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-33783658

13.

PD-1⁺ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.

Kamada, Takahiro; Togashi, Yosuke; Tay, Christopher; Ha, Danbee; Sasaki, Akinori; Nakamura, Yoshiaki; Sato, Eiichi; Fukuoka, Shota; Tada, Yasuko; Tanaka, Atsushi; Morikawa, Hiromasa; Kawazoe, Akihito; Kinoshita, Takahiro; Shitara, Kohei; Sakaguchi, Shimon; Nishikawa, Hiroyoshi.

Proc Natl Acad Sci U S A; 116(20): 9999-10008, 2019 05 14.

Artículo en Inglés | MEDLINE | ID: mdl-31028147

14.

[Clonal Evolution in the Tumor Microenvironment].

Ueda, Youki; Togashi, Yosuke.

Gan To Kagaku Ryoho; 49(9): 907-913, 2022 Sep.

Artículo en Japonés | MEDLINE | ID: mdl-36156003

15.

The potential application of PD-1 blockade therapy for early-stage biliary tract cancer.

Umemoto, Kumiko; Togashi, Yosuke; Arai, Yasuhito; Nakamura, Hiromi; Takahashi, Shinichiro; Tanegashima, Tokiyoshi; Kato, Mikiya; Nishikawa, Tsubasa; Sugiyama, Daisuke; Kojima, Motohiro; Gotohda, Naoto; Kuwata, Takeshi; Ikeda, Masafumi; Shibata, Tatsuhiro; Nishikawa, Hiroyoshi.

Int Immunol; 32(4): 273-281, 2020 04 12.

Artículo en Inglés | MEDLINE | ID: mdl-31867666

16.

TENERGY: multicenter phase II study of Atezolizumab monotherapy following definitive Chemoradiotherapy with 5-FU plus Cisplatin in patients with unresectable locally advanced esophageal squamous cell carcinoma.

Bando, Hideaki; Kotani, Daisuke; Tsushima, Takahiro; Hara, Hiroki; Kadowaki, Shigenori; Kato, Ken; Chin, Keisho; Yamaguchi, Kensei; Kageyama, Shun-Ichiro; Hojo, Hidehiro; Nakamura, Masaki; Tachibana, Hidenobu; Wakabayashi, Masashi; Fukutani, Miki; Togashi, Yosuke; Fuse, Nozomu; Nishikawa, Hiroyoshi; Kojima, Takashi.

BMC Cancer; 20(1): 336, 2020 Apr 20.

Artículo en Inglés | MEDLINE | ID: mdl-32312286

17.

Enhanced tumor response to radiotherapy after PD-1 blockade in metastatic gastric cancer.

Sasaki, Akinori; Nakamura, Yoshiaki; Togashi, Yosuke; Kuno, Hirofumi; Hojo, Hidehiro; Kageyama, Shunichiro; Nakamura, Naoki; Takashima, Kenji; Kadota, Tomohiro; Yoda, Yusuke; Mishima, Saori; Sawada, Kentaro; Kotani, Daisuke; Kawazoe, Akihito; Kuboki, Yasutoshi; Taniguchi, Hiroya; Kojima, Takashi; Doi, Toshihiko; Yoshino, Takayuki; Yano, Tomonori; Kobayashi, Tatsushi; Akimoto, Tetsuo; Nishikawa, Hiroyoshi; Shitara, Kohei.

Gastric Cancer; 23(5): 893-903, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32180056

18.

Mutational activation of the epidermal growth factor receptor down-regulates major histocompatibility complex class I expression via the extracellular signal-regulated kinase in non-small cell lung cancer.

Watanabe, Satomi; Hayashi, Hidetoshi; Haratani, Koji; Shimizu, Shigeki; Tanizaki, Junko; Sakai, Kazuko; Kawakami, Hisato; Yonesaka, Kimio; Tsurutani, Junji; Togashi, Yosuke; Nishio, Kazuto; Ito, Akihiko; Nakagawa, Kazuhiko.

Cancer Sci; 110(1): 52-60, 2019 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-30390416

19.

Clinicopathological features of 22C3 PD-L1 expression with mismatch repair, Epstein-Barr virus status, and cancer genome alterations in metastatic gastric cancer.

Kawazoe, Akihito; Shitara, Kohei; Kuboki, Yasutoshi; Bando, Hideaki; Kojima, Takashi; Yoshino, Takayuki; Ohtsu, Atsushi; Ochiai, Atsushi; Togashi, Yosuke; Nishikawa, Hiroyoshi; Doi, Toshihiko; Kuwata, Takeshi.

Gastric Cancer; 22(1): 69-76, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-29859006

20.

Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation.