Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Más filtros

Bases de datos
Tipo del documento
Intervalo de año de publicación
1.
Biomacromolecules ; 13(1): 84-91, 2012 Jan 09.
Artículo en Inglés | MEDLINE | ID: mdl-22148638

RESUMEN

The synthesis of a supramolecular double hydrophilic block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) as a thermoresponsive block and poly(dimethylaminoethylmethacrylate) (PDMAEMA) as a pH-responsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuli-responsive DHBC micelle system represents an evolution over conventional double stimuli-responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers.


Asunto(s)
Acrilamidas , Antibióticos Antineoplásicos , Doxorrubicina , Metacrilatos , Nanopartículas/química , Nylons , Polímeros , Acrilamidas/química , Acrilamidas/farmacología , Resinas Acrílicas , Antibióticos Antineoplásicos/química , Antibióticos Antineoplásicos/farmacología , Preparaciones de Acción Retardada/química , Preparaciones de Acción Retardada/farmacología , Doxorrubicina/química , Doxorrubicina/farmacología , Células HeLa , Humanos , Metacrilatos/química , Metacrilatos/farmacología , Nylons/química , Nylons/farmacología , Polímeros/química , Polímeros/farmacología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA