Oxygen Saturation Profiles in Healthy Term Infants in Early Postnatal Life.

OBJECTIVE: Oxygen saturation profiles generated by pulse oximetry are used as a clinical tool in the neonatal intensive care unit (NICU). There is limited evidence on normal oxygen saturation profile values in term infants. This study aimed to determine oxygen saturation profiles over an 8-hour monitoring period among healthy term neonates between 24 and 48 hours after birth. STUDY DESIGN: A prospective cohort study of healthy term neonates born at 37 to 41 weeks of gestation. Preductal oxygen saturations were continuously monitored for an 8-hour period between 24 and 48 hours of life using pulse oximetry. Oxygen profile histograms were recorded for analysis. The average percent oxygen saturation (SpO2) was measured over the entire study duration for each neonate and was characterized as the fraction of time of their SpO2 reading was in each of five intervals: ≤80, 81 to 84, 85 to 89, 90 to 94, and 95 to 100%. RESULTS: Seventy-five neonates were included in the study. Median SpO2 was 95.4%. Percentage time spent in each of the five SpO2 intervals was as follows: 0.07 (≤80), 0.15 (81-84), 0.88 (85-89), 26.9 (90-94), and 67.3% (95-100%). Eighteen infants (24%) spent the highest percentage of time in SpO2 of 90 to 94%. CONCLUSION: This study provides reference ranges for oxygen profiles in healthy term neonates during 24 to 48 hours of life. Nearly one-quarter of newborns spent the highest percentage of time in SpO2 of 90 to 94%. This data is important when interpreting oxygen saturation profiles of term neonates admitted to the NICU. KEY POINTS: · This study provide reference ranges for oxygen profiles in healthy term neonates during 24 to 48 hours.. · Median SpO2 was 95.4%.. · Nearly one quarter of newborns spent the highest percentage of time in SpO2 of 90 to 94%..

High Black infant mortality in Wisconsin: factors associated with the ongoing racial inequity.

BACKGROUND: Wisconsin has the highest Black infant mortality rate (IMR) in the nation. OBJECTIVE: Evaluate factors associated with racial inequity in IMR in Wisconsin. STUDY DESIGN: Births/deaths/IMR for Black and White infants from 2011 to 2016 were obtained from the Wisconsin Interactive Statistics on Health system, stratified by gestational age (GA), and compared using direct adjustment method. IMR were compared based on cause of death, maternal age, and education. RESULTS: Crude and adjusted IMR was 13.7 and 9.1 for black infants. Respective IMR for white infants was 4.8 and 5.3. Crude IMR was 180% higher in Black infants. After controlling for GA, IMR among Black infants was 70% higher. In term Black infants, deaths due to sudden infant death syndrome (SIDS), accidents, and assaults were markedly high. CONCLUSIONS: Higher IMR in Black infants was due to increased premature births and increased mortality among term infants. Potentially modifiable causes of death were SIDS, accidents, and assaults.