RESUMEN
Psychedelics are emerging as a therapeutic innovation in psychiatry and their use in chronic pain is worth exploring. In fact, they can modulate the serotonergic system, affecting central pain sensitization mechanisms. Ketamine, used for chronic analgesia, can lead to pain reduction, but additional studies are needed to assess its longterm effectiveness. "Classic" psychedelics are recently attracting renewed interest for their potential effects on chronic pain. Despite limited studies, evidence suggests analgesic benefits, an effect on inflammation, and potential impacts on certain functional disorders. These results pave the way for further research in this ever-evolving field.
Les psychédéliques émergent comme une innovation thérapeutique en psychiatrie et leur utilisation dans la douleur chronique mérite d'être explorée. En effet, ils peuvent moduler le système sérotoninergique, influençant les mécanismes de sensibilisation centrale à la douleur. La kétamine, utilisée en antalgie chronique, peut aboutir à une réduction de la douleur, mais des études supplémentaires sont nécessaires pour évaluer son efficacité à long terme. Les psychédéliques «classiques¼ suscitent un regain d'intérêt récent pour leurs effets potentiels sur la douleur chronique. Malgré des études limitées, des indices suggèrent des bénéfices analgésiques, une influence sur l'inflammation et des impacts potentiels sur certains troubles fonctionnels. Ces résultats ouvrent la voie à de nouvelles recherches dans ce domaine en constante évolution.
Asunto(s)
Dolor Crónico , Alucinógenos , Ketamina , Humanos , Alucinógenos/uso terapéutico , Dolor Crónico/tratamiento farmacológico , Ketamina/uso terapéutico , Analgésicos , Manejo del DolorRESUMEN
The significant progress of psychiatry in the 20th century provided a sophisticated theoretical framework to analyze the complex relationships between crime and mental illness. Schizophrenia has been traditionally associated with severe cognitive and affective deficits that heavily influence empathy, judgment capacities, but also control of impulsiveness. Although there is an association between psychotic disorders and absence or decrease of legal responsibility, their relationship is also determined by sociodemographic, developmental, and clinical factors. These disorders are associated not only with abolished criminal responsibility but also with diminished responsibility. We conduct a systematic literature review to examine the relation between schizophrenia and criminal responsibility. We have found that this clinical entity is often associated with diminished or abolished criminal liability. We discuss these findings, focusing on the specific deficits found in patients with schizophrenia and examining how this problem affects their behavior and eventually their accountability for their crimes.