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1.

Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Patients With Cancer Undergoing Central Line Placement: A Phase 2 Clinical Trial.

Pfeffer, Michael A; Kohs, Tia C L; Vu, Helen H; Jordan, Kelley R; Wang, Jenny Si Han; Lorentz, Christina U; Tucker, Erik I; Puy, Cristina; Olson, Sven R; DeLoughery, Thomas G; Hinds, Monica T; Keshari, Ravi S; Gailani, David; Lupu, Florea; McCarty, Owen J T; Shatzel, Joseph J.

Arterioscler Thromb Vasc Biol; 44(1): 290-299, 2024 01.

Artículo en Inglés | MEDLINE | ID: mdl-37970718

2.

Cytoprotective E-WE thrombin reduces disease severity in a murine model of relapsing-remitting multiple sclerosis.

Verbout, Norah G; Su, Weiping; Pham, Peter; Jordan, Kelley R; Kohs, Tia C L; Tucker, Erik I; McCarty, Owen J T; Sherman, Larry S.

Am J Physiol Cell Physiol; 326(1): C40-C49, 2024 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-37955120

3.

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial.

Lorentz, Christina U; Tucker, Erik I; Verbout, Norah G; Shatzel, Joseph J; Olson, Sven R; Markway, Brandon D; Wallisch, Michael; Ralle, Martina; Hinds, Monica T; McCarty, Owen J T; Gailani, David; Weitz, Jeffrey I; Gruber, András.

Blood; 138(22): 2173-2184, 2021 12 02.

Artículo en Inglés | MEDLINE | ID: mdl-34086880

4.

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus.

Silasi, Robert; Keshari, Ravi S; Regmi, Girija; Lupu, Cristina; Georgescu, Constantin; Simmons, Joe H; Wallisch, Michael; Kohs, Tia C L; Shatzel, Joseph J; Olson, Sven R; Lorentz, Christina U; Puy, Cristina; Tucker, Erik I; Gailani, David; Strickland, Sidney; Gruber, András; McCarty, Owen J T; Lupu, Florea.

Blood; 138(2): 178-189, 2021 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-33598692

5.

Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H.

Puy, Cristina; Pang, Jiaqing; Reitsma, Stéphanie E; Lorentz, Christina U; Tucker, Erik I; Gailani, David; Gruber, András; Lupu, Florea; McCarty, Owen J T.

J Immunol; 206(8): 1784-1792, 2021 04 15.

Artículo en Inglés | MEDLINE | ID: mdl-33811105

6.

Pharmacological targeting of coagulation factor XI attenuates experimental autoimmune encephalomyelitis in mice.

Kohs, Tia C L; Fallon, Meghan E; Oseas, Ethan C; Healy, Laura D; Tucker, Erik I; Gailani, David; McCarty, Owen J T; Vandenbark, Arthur A; Offner, Halina; Verbout, Norah G.

Metab Brain Dis; 38(7): 2383-2391, 2023 10.

Artículo en Inglés | MEDLINE | ID: mdl-37341855

7.

The protein C activator AB002 rapidly interrupts thrombus development in baboons.

Tucker, Erik I; Verbout, Norah G; Markway, Brandon D; Wallisch, Michael; Lorentz, Christina U; Hinds, Monica T; Shatzel, Joseph J; Pelc, Leslie A; Wood, David C; McCarty, Owen J T; Di Cera, Enrico; Gruber, András.

Blood; 135(9): 689-699, 2020 02 27.

Artículo en Inglés | MEDLINE | ID: mdl-31977000

8.

Role of platelets in regulating activated coagulation factor XI activity.

Reitsma, Stéphanie E; Pang, Jiaqing; Raghunathan, Vikram; Shatzel, Joseph J; Lorentz, Christina U; Tucker, Erik I; Gruber, András; Gailani, David; McCarty, Owen J T; Puy, Cristina.

Am J Physiol Cell Physiol; 320(3): C365-C374, 2021 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-33471623

9.

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial.

Lorentz, Christina U; Verbout, Norah G; Wallisch, Michael; Hagen, Matthew W; Shatzel, Joseph J; Olson, Sven R; Puy, Cristina; Hinds, Monica T; McCarty, Owen J T; Gailani, David; Gruber, András; Tucker, Erik I.

Arterioscler Thromb Vasc Biol; 39(4): 799-809, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30700130

10.

Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.

Zilberman-Rudenko, Jevgenia; Reitsma, Stéphanie E; Puy, Cristina; Rigg, Rachel A; Smith, Stephanie A; Tucker, Erik I; Silasi, Robert; Merkulova, Alona; McCrae, Keith R; Maas, Coen; Urbanus, Rolf T; Gailani, David; Morrissey, James H; Gruber, András; Lupu, Florea; Schmaier, Alvin H; McCarty, Owen J T.

Arterioscler Thromb Vasc Biol; 38(8): 1748-1760, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-30354195

11.

Crystalizing our view of the contact system.

Tucker, Erik I.

Blood; 136(14): 1576-1577, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-33002124

12.

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.

Puy, Cristina; Tucker, Erik I; Matafonov, Anton; Cheng, Qiufang; Zientek, Keith D; Gailani, Dave; Gruber, András; McCarty, Owen J T.

Blood; 125(9): 1488-96, 2015 Feb 26.

Artículo en Inglés | MEDLINE | ID: mdl-25587039

13.

Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow.

Zilberman-Rudenko, Jevgenia; Itakura, Asako; Wiesenekker, Chantal P; Vetter, Ralf; Maas, Coen; Gailani, David; Tucker, Erik I; Gruber, András; Gerdes, Christoph; McCarty, Owen J T.

Arterioscler Thromb Vasc Biol; 36(3): 510-7, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26769048

14.

Factor XII inhibition reduces thrombus formation in a primate thrombosis model.

Matafonov, Anton; Leung, Philberta Y; Gailani, Adam E; Grach, Stephanie L; Puy, Cristina; Cheng, Qiufang; Sun, Mao-Fu; McCarty, Owen J T; Tucker, Erik I; Kataoka, Hiroaki; Renné, Thomas; Morrissey, James H; Gruber, Andras; Gailani, David.

Blood; 123(11): 1739-46, 2014 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-24408325

15.

Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis.

Verbout, Norah G; Yu, Xiaolin; Healy, Laura D; Phillips, Kevin G; Tucker, Erik I; Gruber, András; McCarty, Owen J T; Offner, Halina.

Metab Brain Dis; 30(1): 57-65, 2015 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-24810631

16.

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis.

Tucker, Erik I; Verbout, Norah G; Leung, Philberta Y; Hurst, Sawan; McCarty, Owen J T; Gailani, David; Gruber, András.

Blood; 119(20): 4762-8, 2012 May 17.

Artículo en Inglés | MEDLINE | ID: mdl-22442348

17.

Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates.

Crosby, Jeffrey R; Marzec, Ulla; Revenko, Alexey S; Zhao, Chenguang; Gao, Dacao; Matafonov, Anton; Gailani, David; MacLeod, A Robert; Tucker, Erik I; Gruber, Andras; Hanson, Stephen R; Monia, Brett P.

Arterioscler Thromb Vasc Biol; 33(7): 1670-8, 2013 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-23559626

18.

Pharmacologic targeting of coagulation factors XII and XI by monoclonal antibodies reduces thrombosis in nitinol stents under flow.

Keeling, Novella M; Wallisch, Michael; Johnson, Jennifer; Le, Hillary H; Vu, Helen H; Jordan, Kelley R; Puy, Cristina; Tucker, Erik I; Nguyen, Khanh P; McCarty, Owen J T; Aslan, Joseph E; Hinds, Monica T; Anderson, Deirdre E J.

J Thromb Haemost; 22(5): 1433-1446, 2024 May.

Artículo en Inglés | MEDLINE | ID: mdl-38331196

19.

Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia.

Kohs, Tia C L; Vu, Helen H; Jordan, Kelley R; Parra-Izquierdo, Iván; Hinds, Monica T; Shatzel, Joseph J; Kievit, Paul; Morgan, Terry K; Yunga, Samuel Tassi; Ngo, Thuy T M; Aslan, Joseph E; Wallisch, Michael; Lorentz, Christina U; Tucker, Erik I; Gailani, David; Lindner, Jonathan R; Puy, Cristina; McCarty, Owen J T.

Res Pract Thromb Haemost; 8(1): 102276, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-38226339

20.

Size matters.

Gruber, Andras; Tucker, Erik I.

Blood; 118(25): 6481-2, 2011 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-22174307

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