RESUMEN
Two new methoxy lactone chlorins ficusmicrochlorin A (1) and ficusmicrochlorin B (2), and one new anhydride chlorin ficusmicrochlorin C (3), along with eight known pheophytins were isolated from the leaves of Ficus microcarpa. Their structures were determined by the extensive 1D- and 2D-NMR techniques. New pheophytin compound was rarely obtained from natural sources. In the past ten years, only three new natural pheophytins were characterized.
Asunto(s)
Ficus/química , Lactonas/química , Porfirinas/química , Lactonas/aislamiento & purificación , Espectroscopía de Resonancia Magnética , Conformación Molecular , Hojas de la Planta/química , Porfirinas/aislamiento & purificaciónRESUMEN
Four new lactone chlorins, ficuschlorins A - D (1-4, resp.), and six known pheophytins were isolated from the leaves of Ficus microcarpa. The structures of these compounds were determined by 1D- and 2D-NMR spectroscopy, and other techniques. New natural pheophytins were rarely obtained. In the past ten years, only three new pheophytins were isolated from natural sources.
Asunto(s)
Ficus/química , Lactonas/química , Porfirinas/química , Espectroscopía de Resonancia Magnética , Conformación Molecular , Hojas de la Planta/química , Porfirinas/aislamiento & purificaciónRESUMEN
Two new fernane triterpenoids, 7alpha-hydroxyfern-8-en-11-one (1) and 11beta-hydroxyfern-8-en-7-one (2), and two new filicane triterpenoids, 3beta-hydroxyfilic-4(23)-ene (3) and filicenol (5), together with one known filicane-type triterpenoid, 3alpha-hydroxyfilic-4(23)-ene (4), were isolated from the methyl alcohol extract of the leaves of Angiopteris palmiformis. Their structures were elucidated on the basis of extensive analyses of their spectroscopic data (NMR, MS, IR) and comparison with spectroscopic data in the literature.
Asunto(s)
Helechos/química , Hojas de la Planta/química , Triterpenos/química , Conformación Molecular , Especificidad de la Especie , Estereoisomerismo , Triterpenos/aislamiento & purificaciónRESUMEN
Four novel octanorcucurbitane triterpenes, octanorcucurbitacins A-D (1-4), together with one known octanorcucurbitane triterpene, kuguacin M (5), were isolated from the methyl alcohol extract of the stems of Momordica charantia. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 3 inhibited tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity against HepG2 cells.
Asunto(s)
Citoprotección , Glicósidos/análisis , Glicósidos/farmacología , Hepatocitos/efectos de los fármacos , Momordica charantia/química , Triterpenos/análisis , Triterpenos/farmacología , terc-Butilhidroperóxido/efectos adversos , Supervivencia Celular/efectos de los fármacos , Glicósidos/aislamiento & purificación , Células Hep G2 , Hepatocitos/citología , Humanos , Estructura Molecular , Triterpenos/aislamiento & purificaciónRESUMEN
Four new lanostane-type triterpenes, 24-ethyl-3beta-methoxylanost-9(11)-en-25-ol (1), 3beta-methoxy-24-methylenelanost-9(11)-en-25-ol (2), 3beta-methoxy-25-methyl-24-methylenelanost-9(11)-en-21-ol (3) and 3beta-methoxy-24-methyllanosta-9(11),25-dien-24-ol (4) together with three known triterpenes, betulinaldehyde, betulinic acid methyl ester, and ursaldehyde have been isolated from the methanol extract of the twigs of Diospyros discolor. The structures of those new compounds were elucidated by spectroscopic methods.