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1.
J Neural Transm (Vienna) ; 129(5-6): 661-674, 2022 06.
Artículo en Inglés | MEDLINE | ID: mdl-34837533

RESUMEN

OBJECTIVES: Posttraumatic stress disorder (PTSD) is triggered by extremely stressful environmental events and characterized by high emotional distress, re-experiencing of trauma, avoidance and hypervigilance. The present study uses polygenic risk scores (PRS) derived from the UK Biobank (UKBB) mega-cohort analysis as part of the PGC PTSD GWAS effort to determine the heritable basis of PTSD in the South Eastern Europe (SEE)-PTSD cohort. We further analyzed the relation between PRS and additional disease-related variables, such as number and intensity of life events, coping, sex and age at war on PTSD and CAPS as outcome variables. METHODS: Association of PRS, number and intensity of life events, coping, sex and age on PTSD were calculated using logistic regression in a total of 321 subjects with current and remitted PTSD and 337 controls previously subjected to traumatic events but not having PTSD. In addition, PRS and other disease-related variables were tested for association with PTSD symptom severity, measured by the Clinician Administrated PTSD Scale (CAPS) by liner regression. To assess the relationship between the main outcomes PTSD diagnosis and symptom severity, each of the examined variables was adjusted for all other PTSD related variables. RESULTS: The categorical analysis showed significant polygenic risk in patients with remitted PTSD and the total sample, whereas no effects were found on symptom severity. Intensity of life events as well as the individual coping style were significantly associated with PTSD diagnosis in both current and remitted cases. The dimensional analyses showed as association of war-related frequency of trauma with symptom severity, whereas the intensity of trauma yielded significant results independently of trauma timing in current PTSD. CONCLUSIONS: The present PRS application in the SEE-PTSD cohort confirms modest but significant polygenic risk for PTSD diagnosis. Environmental factors, mainly the intensity of traumatic life events and negative coping strategies, yielded associations with PTSD both categorically and dimensionally with more significant p-values. This suggests that, at least in the present cohort of war-related trauma, the association of environmental factors and current individual coping strategies with PTSD psychopathology was stronger than the polygenic risk.


Asunto(s)
Trastornos por Estrés Postraumático , Adaptación Psicológica , Emociones , Europa Oriental , Humanos , Factores de Riesgo , Trastornos por Estrés Postraumático/diagnóstico , Trastornos por Estrés Postraumático/genética , Trastornos por Estrés Postraumático/psicología
2.
Med Arch ; 70(2): 151-3, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-27147793

RESUMEN

INTRODUCTION: Belching is often reported symptom. It is rarely an isolated disorder and mainly occurs within various gastroduodenal diseases. AIM: The aim is to show the great breadth of clinical symptoms of postcholecystectomy syndrome which should have a multidisciplinary therapeutic approach taking into account all aspects of patient's life. CASE REPORT: We report a case of excessive belching within postcholecystectomy syndrome which disturbs the general psycho-physical condition of the patient, with symptoms of depression and anxiety, and social isolation, which significantly reduces the quality of his life.


Asunto(s)
Colecistectomía Laparoscópica/efectos adversos , Eructación/psicología , Pancreatitis/cirugía , Síndrome Poscolecistectomía/psicología , Complicaciones Posoperatorias/psicología , Ansiedad , Depresión , Eructación/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Síndrome Poscolecistectomía/fisiopatología , Calidad de Vida , Aislamiento Social/psicología , Factores de Tiempo
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