Effect of body composition on isoflurane induction and recovery times in the meadow vole.

The inhalation anesthetic isoflurane is five times more soluble in lipid than in lean tissue. Using the meadow vole as a model, the authors sought to determine the effect of body composition on isoflurane induction and recovery times.

The effects of lipid location on non-invasive estimates of body composition using EM-SCAN technology.

We evaluated the effect of lipid location on body-composition estimation accuracy using electromagnetic scanning (EM-SCAN), a non-invasive [total body electrical conductivity (TOBEC)] method. Molds were constructed that simulated a 'general' small mammal, either 93% lean/7% lipid (control) or 82% lean/18% lipid (lipid-location groups). In the 18% lipid molds, we varied the location of the fat; simulating all the fat in the head, tail or midsection or simulating homogenous distribution. Comparisons were made between the EM-SCAN output of each lipid-location group, and multiple-regression techniques were performed to derive body-composition estimation equations for both lipid mass (M(L)) and fat-free mass (M(FF)). Device output varied significantly for all lipid-location groups even though all groups contained 18% body fat, showing a lipid-location effect on device output. Calibration equations derived for each lipid-location condition estimated both M(L) and M(FF) accurately, but an independent equation was required for each lipid-location condition. In situations where species significantly vary body fat content and location, for example during hibernation or reproductive periods, we suggest deriving a calibration equation that is more representative of the actual body composition to improve M(L) and M(FF) estimation accuracy using non-invasive EM-SCAN methods.

The relationship between participation restrictions and selected clinical measures following anterior cruciate ligament reconstruction.

This study examined the relationship between participation restrictions in activities of daily living and sports following anterior cruciate ligament reconstruction (ACLR) and the status of knee structures, performance-based activity limitations, and impairments. Fifty subjects (36 men, 14 women, age=20.6 +/- 1.3 years) at a mean of 31.0 +/- 16.3 months following ACLR participated in this study. Participation restrictions in activities of daily living and sports were measured by the combined scores of the Knee Outcome Survey Activities of Daily Living Scale and Sports Activity Scale. The status of knee structures was assessed by determining the number of previously injured structures in the knee and the time from the most recent ACLR to testing. Performance-based activity limitations were assessed with the single leg hop for distance test. Impairments included isokinetic quadriceps function and anterior tibiofemoral joint laxity. Forward stepwise regression analysis revealed that while the number of injured knee structures alone accounted for 47% of the variability in patient-reported participation restrictions, the combination of the number of injured knee structures, time from ACLR, and the hop index provided the most effective estimate of participation restrictions. Isokinetic quadriceps function and KT-1000 side-to-side differences were not entered into the regression model and were not significant predictors of participation restrictions. We recommend that clinicians use caution in assuming that isokinetic quadriceps function and anterior tibiofemoral joint laxity provide an effective estimate of participation restrictions.