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Biosci Biotechnol Biochem ; 87(2): 171-178, 2023 Jan 24.
Artículo en Inglés | MEDLINE | ID: mdl-36507740

RESUMEN

The FMRFamide-like peptides (FLPs) are conserved in both free-living and parasitic nematodes. This molecular genetic study verified the relevance of the flp-1 gene, which is conserved in many nematode species, to the larval development of the free-living soil nematode Caenorhabditis elegans. Using C. elegans as a model, we found that: (1) FLP-1 suppressed larval development, resulting in diapause; (2) the secretion of FLP-1, which is produced in AVK head neurons, was suppressed by the presence of food (Escherichia coli) as an environmental factor to continue larval development; (3) the FLP-1 reduced the production and secretion of DAF-28, which is produced in ASI head neurons and is the predominant insulin-like peptide (INS) present. FLP-1 is conserved in many species of plant-parasitic root-knot nematodes that cause severe damage to crops. Therefore, our findings may provide insight into the development of new nematicides that can disturb their infection and development.


Asunto(s)
Proteínas de Caenorhabditis elegans , Nematodos , Neuropéptidos , Animales , Caenorhabditis elegans/genética , FMRFamida/química , FMRFamida/genética , Insulina , Nematodos/genética , Péptidos , Proteínas de Caenorhabditis elegans/genética
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