Detalles de la búsqueda
1.
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Cell;
186(5): 1013-1025.e24, 2023 03 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36827973
2.
Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis.
Antimicrob Agents Chemother;
68(4): e0156223, 2024 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38376228
3.
Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model.
Antimicrob Agents Chemother;
67(4): e0003523, 2023 04 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36920217
4.
Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data.
J Infect Dis;
225(11): 1876-1885, 2022 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33606880
5.
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Antimicrob Agents Chemother;
66(6): e0013222, 2022 06 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35607978
6.
Delamanid or pretomanid? A Solomonic judgement!
J Antimicrob Chemother;
77(4): 880-902, 2022 03 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35089314
7.
Comparative Efficacy of the Novel Diarylquinoline TBAJ-876 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother;
65(12): e0141221, 2021 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34570644
8.
Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother;
65(4)2021 03 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33526488
9.
Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis.
Antimicrob Agents Chemother;
65(7): e0025321, 2021 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33903099
10.
TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity.
Antimicrob Agents Chemother;
64(2)2020 01 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31712198
11.
Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology.
Bioorg Med Chem;
28(1): 115213, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31810890
12.
Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis.
Bioorg Med Chem;
28(22): 115784, 2020 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33007562
13.
Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline.
Molecules;
25(6)2020 Mar 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-32245020
14.
Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria.
Molecules;
25(10)2020 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32456032
15.
TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase.
Antimicrob Agents Chemother;
63(10)2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31358589
16.
Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis.
Antimicrob Agents Chemother;
63(5)2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30833432
17.
Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline.
Bioorg Med Chem;
27(7): 1283-1291, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30792104
18.
3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.
Bioorg Med Chem;
27(7): 1292-1307, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30803745
19.
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles.
Bioorg Med Chem;
26(8): 1797-1809, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29482950
20.
Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units.
Bioorg Med Chem Lett;
27(23): 5190-5196, 2017 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29107541