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1.
Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Chembiochem;
22(12): 2107-2110, 2021 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33838082
2.
Identification of azabenzimidazoles as potent JAK1 selective inhibitors.
Bioorg Med Chem Lett;
26(1): 60-7, 2016 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26614408
3.
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Cell Chem Biol;
28(8): 1158-1168.e13, 2021 08 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33705687
4.
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
J Med Chem;
64(20): 15189-15213, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34647738
5.
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Cancer Cell;
39(9): 1214-1226.e10, 2021 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34375612
6.
Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes.
SLAS Discov;
25(3): 241-252, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-31855104
7.
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.
Cell Chem Biol;
27(7): 877-887.e14, 2020 07 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32679093
8.
Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.
J Med Chem;
63(9): 4517-4527, 2020 05 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32297743
9.
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
J Med Chem;
63(24): 15564-15590, 2020 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33306391
10.
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.
Bioorg Med Chem Lett;
18(14): 4242-8, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18547806
11.
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
J Med Chem;
61(3): 1061-1073, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29301085
12.
Dual catalyst control in the enantioselective intramolecular Morita-Baylis-Hillman reaction.
Org Lett;
7(18): 3849-51, 2005 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16119914
13.
Peptide bond isosteres: ester or (E)-alkene in the backbone of the collagen triple helix.
Org Lett;
7(13): 2619-22, 2005 Jun 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-15957905
14.
Small molecule inhibitor of apoptosis proteins antagonists: a patent review.
Expert Opin Ther Pat;
25(7): 755-74, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25980951
15.
Dual catalyst control in the amino acid-peptide-catalyzed enantioselective Baylis-Hillman reaction.
Org Lett;
5(20): 3741-3, 2003 Oct 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-14507219
16.
Stereocontrol in Intermolecular Dirhodium(II)-Catalyzed Carbonyl Ylide Formation and Reactions. Dioxolanes and Dihydrofurans.
J Org Chem;
62(21): 7210-7215, 1997 Oct 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11671830
17.
Incorporation of Peptide Isosteres into Enantioselective Peptide-Based Catalysts as Mechanistic Probes.
Angew Chem Int Ed Engl;
40(15): 2824-2827, 2001 Aug 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29711981
18.
Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
J Med Chem;
56(5): 1996-2015, 2013 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23398453
19.
Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).
J Med Chem;
56(24): 9897-919, 2013 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24320998
20.
Incorporation of Peptide Isosteres into Enantioselective Peptide-Based Catalysts as Mechanistic Probes This research is supported by the U.S. National Science Foundation (CHE-9874963). We are also grateful to the U.S. NIH (GM-57595), DuPont, Eli Lilly, Glaxo-Wellcome, and Merck for research support. S.J.M. is a Fellow of the Alfred P. Sloan Foundation, a Cottrell Scholar of Research Corporation, and a Camille Dreyfus Teacher-Scholar.
Angew Chem Int Ed Engl;
40(15): 2824-2827, 2001 Aug 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-11500878