RESUMEN
Atypical teratoid/rhabdoid tumours (AT/RT) are aggressive neoplasms of the central nervous system occurring mainly in the paediatric population. We reported a 32-year-old male patient who was admitted in emergency in unconscious state. The neoplasm was localised in the left frontal region and was totally excised. The histological and immunohistochemical report revealed AT/RT. This unusual presentation underlines the necessity of considering this devastating neoplasm in the differential diagnosis of malignant brain tumours of adults.
Asunto(s)
Neoplasias del Sistema Nervioso Central/patología , Tumor Rabdoide/patología , Teratoma/patología , Adulto , Neoplasias del Sistema Nervioso Central/diagnóstico por imagen , Neoplasias del Sistema Nervioso Central/cirugía , Humanos , Masculino , Radiografía , Tumor Rabdoide/diagnóstico por imagen , Tumor Rabdoide/cirugía , Teratoma/diagnóstico por imagen , Teratoma/cirugía , Resultado del TratamientoRESUMEN
AIMS: To determine the possible histogenesis of the intracranial variant of olfactory neuroblastoma. METHODS: Four specimens from three cases of intracranial olfactory neuroblastoma were studied by light microscopy and immuno-histochemistry, and electron microscopy in two cases. RESULTS: Light microscopical examination showed small cell tumour with additional features of epithelioid cells in one case and ganglion cells in another. Olfactory and Homer-Wright rosettes were present. All the specimens showed a uniform positive reaction to neurone specific enolase, S-100, and cytokeratin antibodies. Glial fibrillary acidic protein was absent. The salient electron microscopic features were the presence of cell junctions, cytoplasmic intermediate filaments, basal bodies and cytolasmic processes. Dense cored vesicles were absent. CONCLUSIONS: The results strongly support the view that intracranial olfactory neuroblastomas are of olfactory epithelial origin and differ from conventional neuroblastomas.