Dynamical topological phase realized in a trapped-ion quantum simulator.

Nascent platforms for programmable quantum simulation offer unprecedented access to new regimes of far-from-equilibrium quantum many-body dynamics in almost isolated systems. Here achieving precise control over quantum many-body entanglement is an essential task for quantum sensing and computation. Extensive theoretical work indicates that these capabilities can enable dynamical phases and critical phenomena that show topologically robust methods to create, protect and manipulate quantum entanglement that self-correct against large classes of errors. However, so far, experimental realizations have been confined to classical (non-entangled) symmetry-breaking orders1-5. In this work, we demonstrate an emergent dynamical symmetry-protected topological phase6, in a quasiperiodically driven array of ten 171Yb+ hyperfine qubits in Quantinuum's System Model H1 trapped-ion quantum processor7. This phase shows edge qubits that are dynamically protected from control errors, cross-talk and stray fields. Crucially, this edge protection relies purely on emergent dynamical symmetries that are absolutely stable to generic coherent perturbations. This property is special to quasiperiodically driven systems: as we demonstrate, the analogous edge states of a periodically driven qubit array are vulnerable to symmetry-breaking errors and quickly decohere. Our work paves the way for implementation of more complex dynamical topological orders8,9 that would enable error-resilient manipulation of quantum information.

Subdiffusive hydrodynamics of nearly integrable anisotropic spin chains.

We address spin transport in the easy-axis Heisenberg spin chain subject to different integrability-breaking perturbations. We find subdiffusive spin transport characterized by dynamical exponent z = 4 up to a timescale parametrically long in the anisotropy. In the limit of infinite anisotropy, transport is subdiffusive at all times; for finite anisotropy, one eventually recovers diffusion at late times but with a diffusion constant independent of the strength of the perturbation and solely fixed by the value of the anisotropy. We provide numerical evidence for these findings, and we show how they can be understood in terms of the dynamical screening of the relevant quasiparticle excitations and effective dynamical constraints. Our results show that the diffusion constant of near-integrable diffusive spin chains is generically not perturbative in the integrability-breaking strength.

Tunable Superdiffusion in Integrable Spin Chains Using Correlated Initial States.

Although integrable spin chains host only ballistically propagating particles, they can still feature diffusive charge transfer. This diffusive charge transfer originates from quasiparticle charge fluctuations inherited from the initial state's magnetization Gaussian fluctuations. We show that ensembles of initial states with quasi-long-range correlations lead to superdiffusive charge transfer with a tunable dynamical exponent. We substantiate our prediction with numerical simulations and discuss how finite time and finite size effects might cause deviations.

Hydrodynamic nonlinear response of interacting integrable systems.

We develop a formalism for computing the nonlinear response of interacting integrable systems. Our results are asymptotically exact in the hydrodynamic limit where perturbing fields vary sufficiently slowly in space and time. We show that spatially resolved nonlinear response distinguishes interacting integrable systems from noninteracting ones, exemplifying this for the Lieb-Liniger gas. We give a prescription for computing finite-temperature Drude weights of arbitrary order, which is in excellent agreement with numerical evaluation of the third-order response of the XXZ spin chain. We identify intrinsically nonperturbative regimes of the nonlinear response of integrable systems.

Anomalous transport from hot quasiparticles in interacting spin chains.

Many experimentally relevant quantum spin chains are approximately integrable, and support long-lived quasiparticle excitations. A canonical example of integrable model of quantum magnetism is the XXZ spin chain, for which energy spreads ballistically, but, surprisingly, spin transport can be diffusive or superdiffusive. We review the transport properties of this model using an intuitive quasiparticle picture that relies on the recently introduced framework of generalized hydrodynamics. We discuss how anomalous linear response properties emerge from hierarchies of quasiparticles both in integrable and near-integrable limits, with an emphasis on the role of hydrodynamic fluctuations. We also comment on recent developments including non-linear response, full-counting statistics and far-from-equilibrium transport. We provide an overview of recent numerical and experimental results on transport in XXZ spin chains.

Integrability Breaking from Backscattering.

We analyze the onset of diffusive hydrodynamics in the one-dimensional hard-rod gas subject to stochastic backscattering. While this perturbation breaks integrability and leads to a crossover from ballistic to diffusive transport, it preserves infinitely many conserved quantities corresponding to even moments of the velocity distribution of the gas. In the limit of small noise, we derive the exact expressions for the diffusion and structure factor matrices, and show that they generically have off diagonal components. We find that the particle density structure factor is non-Gaussian and singular near the origin, with a return probability showing logarithmic deviations from diffusion.

Fredkin Staircase: An Integrable System with a Finite-Frequency Drude Peak.

We introduce and explore an interacting integrable cellular automaton, the Fredkin staircase, that lies outside the existing classification of such automata, and has a structure that seems to lie beyond that of any existing Bethe-solvable model. The Fredkin staircase has two families of ballistically propagating quasiparticles, each with infinitely many species. Despite the presence of ballistic quasiparticles, charge transport is diffusive in the dc limit, albeit with a highly non-Gaussian dynamic structure factor. Remarkably, this model exhibits persistent temporal oscillations of the current, leading to a delta-function singularity (Drude peak) in the ac conductivity at nonzero frequency. We analytically construct an extensive set of operators that anticommute with the time-evolution operator; the existence of these operators both demonstrates the integrability of the model and allows us to lower bound the weight of this finite-frequency singularity.

Nonlinear Fluctuating Hydrodynamics for Kardar-Parisi-Zhang Scaling in Isotropic Spin Chains.

Finite temperature spin transport in integrable isotropic spin chains is known to be superdiffusive, with dynamical spin correlations that are conjectured to fall into the Kardar-Parisi-Zhang (KPZ) universality class. However, integrable spin chains have time-reversal and parity symmetries that are absent from the KPZ (Kardar-Parisi-Zhang) or stochastic Burgers equation, which force higher-order spin fluctuations to deviate from standard KPZ predictions. We put forward a nonlinear fluctuating hydrodynamic theory consisting of two coupled stochastic modes: the local spin magnetization and its effective velocity. Our theory fully explains the emergence of anomalous spin dynamics in isotropic chains: it predicts KPZ scaling for the spin structure factor but with a symmetric, quasi-Gaussian, distribution of spin fluctuations. We substantiate our results using matrix-product states calculations.

Full Counting Statistics of Charge in Chaotic Many-Body Quantum Systems.

We investigate the full counting statistics of charge transport in U(1)-symmetric random unitary circuits. We consider an initial mixed state prepared with a chemical potential imbalance between the left and right halves of the system and study the fluctuations of the charge transferred across the central bond in typical circuits. Using an effective replica statistical mechanics model and a mapping onto an emergent classical stochastic process valid at large on-site Hilbert space dimension, we show that charge transfer fluctuations approach those of the symmetric exclusion process at long times, with subleading t^{-1/2} quantum corrections. We discuss our results in the context of fluctuating hydrodynamics and macroscopic fluctuation theory of classical nonequilibrium systems and check our predictions against direct matrix-product state calculations.

Divergent Nonlinear Response from Quasiparticle Interactions.

We demonstrate that nonlinear response functions in many-body systems carry a sharp signature of interactions between gapped low-energy quasiparticles. Such interactions are challenging to deduce from linear response measurements. The signature takes the form of a divergent-in-time contribution to the response-linear in time in the case when quasiparticles propagate ballistically-that is absent for free bosonic excitations. We give a physically transparent semiclassical picture of this singular behavior. While the semiclassical picture applies to a broad class of systems we benchmark it in two simple models: in the Ising chain using a form-factor expansion, and in a nonintegrable model-the spin-1 Affleck-Kennedy-Lieb-Tasaki chain-using time-dependent density matrix renormalization group simulations. We comment on extensions of these results to finite temperatures.

Transitions in the Learnability of Global Charges from Local Measurements.

We consider monitored quantum systems with a global conserved charge, and ask how efficiently an observer ("eavesdropper") can learn the global charge of such systems from local projective measurements. We find phase transitions as a function of the measurement rate, depending on how much information about the quantum dynamics the eavesdropper has access to. For random unitary circuits with U(1) symmetry, we present an optimal classical classifier to reconstruct the global charge from local measurement outcomes only. We demonstrate the existence of phase transitions in the performance of this classifier in the thermodynamic limit. We also study numerically improved classifiers by including some knowledge about the unitary gates pattern.

Field Theory of Charge Sharpening in Symmetric Monitored Quantum Circuits.

Monitored quantum circuits (MRCs) exhibit a measurement-induced phase transition between area-law and volume-law entanglement scaling. MRCs with a conserved charge additionally exhibit two distinct volume-law entangled phases that cannot be characterized by equilibrium notions of symmetry-breaking or topological order, but rather by the nonequilibrium dynamics and steady-state distribution of charge fluctuations. These include a charge-fuzzy phase in which charge information is rapidly scrambled leading to slowly decaying spatial fluctuations of charge in the steady state, and a charge-sharp phase in which measurements collapse quantum fluctuations of charge without destroying the volume-law entanglement of neutral degrees of freedom. By taking a continuous-time, weak-measurement limit, we construct a controlled replica field theory description of these phases and their intervening charge-sharpening transition in one spatial dimension. We find that the charge fuzzy phase is a critical phase with continuously evolving critical exponents that terminates in a modified Kosterlitz-Thouless transition to the short-range correlated charge-sharp phase. We numerically corroborate these scaling predictions also hold for discrete-time projective-measurement circuit models using large-scale matrix-product state simulations, and discuss generalizations to higher dimensions.

Anomalous relaxation and the high-temperature structure factor of XXZ spin chains.

We compute the spin-structure factor of XXZ spin chains in the Heisenberg and gapped (Ising) regimes in the high-temperature limit for nonzero magnetization, within the framework of generalized hydrodynamics, including diffusive corrections. The structure factor shows a hierarchy of timescales in the gapped phase, owing to s-spin magnon bound states ("strings") of various sizes. Although short strings move ballistically, long strings move primarily diffusively as a result of their collisions with short strings. The interplay between these effects gives rise to anomalous power-law decay of the spin-structure factor, with continuously varying exponents, at any fixed separation in the late-time limit. We elucidate the cross-over to diffusion (in the gapped phase) and to superdiffusion (at the isotropic point) in the half-filling limit. We verify our results via extensive matrix product operator calculations.

Stability of Superdiffusion in Nearly Integrable Spin Chains.

Superdiffusive finite-temperature transport has been recently observed in a variety of integrable systems with non-Abelian global symmetries. Superdiffusion is caused by giant Goldstone-like quasiparticles stabilized by integrability. Here, we argue that these giant quasiparticles remain long-lived and give divergent contributions to the low-frequency conductivity σ(ω), even in systems that are not perfectly integrable. We find, perturbatively, that σ(ω)∼ω^{-1/3} for translation-invariant static perturbations that conserve energy and σ(ω)∼|logω| for noisy perturbations. The (presumable) crossover to regular diffusion appears to lie beyond low-order perturbation theory. By contrast, integrability-breaking perturbations that break the non-Abelian symmetry yield conventional diffusion. Numerical evidence supports the distinction between these two classes of perturbations.

Subdiffusion and Many-Body Quantum Chaos with Kinetic Constraints.

We investigate the spectral and transport properties of many-body quantum systems with conserved charges and kinetic constraints. Using random unitary circuits, we compute ensemble-averaged spectral form factors and linear-response correlation functions, and find that their characteristic timescales are given by the inverse gap of an effective Hamiltonian-or equivalently, a transfer matrix describing a classical Markov process. Our approach allows us to connect directly the Thouless time, t_{Th}, determined by the spectral form factor, to transport properties and linear-response correlators. Using tensor network methods, we determine the dynamical exponent z for a number of constrained, conserving models. We find universality classes with diffusive, subdiffusive, quasilocalized, and localized dynamics, depending on the severity of the constraints. In particular, we show that quantum systems with "Fredkin" constraints exhibit anomalous transport with dynamical exponent z≃8/3.

Floquet quantum criticality.

We study transitions between distinct phases of one-dimensional periodically driven (Floquet) systems. We argue that these are generically controlled by infinite-randomness fixed points of a strong-disorder renormalization group procedure. Working in the fermionic representation of the prototypical Floquet Ising chain, we leverage infinite randomness physics to provide a simple description of Floquet (multi)criticality in terms of a distinct type of domain wall associated with time translational symmetry-breaking and the formation of "Floquet time crystals." We validate our analysis via numerical simulations of free-fermion models sufficient to capture the critical physics.

Quantum Criticality in the 2D Quasiperiodic Potts Model.

Quantum critical points in quasiperiodic magnets can realize new universality classes, with critical properties distinct from those of clean or disordered systems. Here, we study quantum phase transitions separating ferromagnetic and paramagnetic phases in the quasiperiodic q-state Potts model in 2+1D. Using a controlled real-space renormalization group approach, we find that the critical behavior is largely independent of q, and is controlled by an infinite-quasiperiodicity fixed point. The correlation length exponent is found to be ν=1, saturating a modified version of the Harris-Luck criterion.

Superdiffusion from Emergent Classical Solitons in Quantum Spin Chains.

Finite-temperature spin transport in the quantum Heisenberg spin chain is known to be superdiffusive, and has been conjectured to lie in the Kardar-Parisi-Zhang (KPZ) universality class. Using a kinetic theory of transport, we compute the KPZ coupling strength for the Heisenberg chain as a function of temperature, directly from microscopics; the results agree well with density-matrix renormalization group simulations. We establish a rigorous quantum-classical correspondence between the "giant quasiparticles" that govern superdiffusion and solitons in the classical continuous Landau-Lifshitz ferromagnet. We conclude that KPZ universality has the same origin in classical and quantum integrable isotropic magnets: a finite-temperature gas of low-energy classical solitons.

Gemcitabine-induced epithelial-mesenchymal transition-like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal-like phenotype.

Growing body of evidence suggests that epithelial-mesenchymal transition (EMT) is a critical process in tumor progression and chemoresistance in pancreatic cancer (PC). The aim of this study was to analyze the role of EMT-like changes in acquisition of resistance to gemcitabine in pancreatic cells of the mesenchymal or epithelial phenotype. Therefore, chemoresistant BxPC-3, Capan-2, Panc-1, and MiaPaca-2 cells were selected by chronic exposure to increasing concentrations of gemcitabine. We show that gemcitabine-resistant Panc-1 and MiaPaca-2 cells of mesenchymal-like phenotype undergo further EMT-like molecular changes mediated by ERK-ZEB-1 pathway, and that inhibition of ERK1/2 phosphorylation or ZEB-1 expression resulted in a decrease in chemoresistance. Conversely, gemcitabine-resistant BxPC-3 and Capan-2 cells of epithelial-like phenotype did not show such typical EMT-like molecular changes although the expression of the tight junction marker occludin could be found decreased. In pancreatic cancer patients, high ZEB-1 expression was associated with tumor invasion and tumor budding. In addition, tumor budding was essentially observed in patients treated with neoadjuvant chemotherapy. These findings support the notion that gemcitabine treatment induces EMT-like changes that sustain invasion and chemoresistance in PC cells.

Kinetic Theory of Spin Diffusion and Superdiffusion in XXZ Spin Chains.

We address the nature of spin transport in the integrable XXZ spin chain, focusing on the isotropic Heisenberg limit. We calculate the diffusion constant using a kinetic picture based on generalized hydrodynamics combined with Gaussian fluctuations: we find that it diverges, and show that a self-consistent treatment of this divergence gives superdiffusion, with an effective time-dependent diffusion constant that scales as D(t)∼t^{1/3}. This exponent had previously been observed in large-scale numerical simulations, but had not been theoretically explained. We briefly discuss XXZ models with easy-axis anisotropy Δ>1. Our method gives closed-form expressions for the diffusion constant D in the infinite-temperature limit for all Δ>1. We find that D saturates at large anisotropy, and diverges as the Heisenberg limit is approached, as D∼(Δ-1)^{-1/2}.