Piezo-deformable mirrors for active mode matching in advanced LIGO.

The detectors of the laser interferometer gravitational-wave observatory (LIGO) are broadly limited by the quantum noise and rely on the injection of squeezed states of light to achieve their full sensitivity. Squeezing improvement is limited by mode mismatch between the elements of the squeezer and the interferometer. In the current LIGO detectors, there is no way to actively mitigate this mode mismatch. This paper presents a new deformable mirror for wavefront control that meets the active mode matching requirements of advanced LIGO. The active element is a piezo-electric transducer, which actuates on the radius of curvature of a 5 mm thick mirror via an axisymmetric flexure. The operating range of the deformable mirror is 120±8 mD in vacuum and an additional 200 mD adjustment range accessible out of vacuum. Combining the operating range and the adjustable static offset, it is possible to deform a flat mirror from -65 mD to -385 mD. The measured bandwidth of the actuator and driver electronics is 6.8 Hz. The scattering into higher-order modes is measured to be <0.2% over the nominal beam radius. These piezo-deformable mirrors meet the stringent noise and vacuum requirements of advanced LIGO and will be used for the next observing run (O4) to control the mode-matching between the squeezer and the interferometer.

Differential wavefront sensing and control using radio-frequency optical demodulation.

Differential wavefront sensing is an essential technique for optimising the performance of many precision interferometric experiments. Perhaps the most extensive application of this is for alignment sensing using radio-frequency beats measured with quadrant photodiodes. Here we present a new technique that uses optical demodulation to measure such optical beats at high resolutions using commercial laboratory equipment. We experimentally demonstrate that the images captured can be digitally processed to generate wavefront error signals and use these in a closed loop control system for correct wavefront errors for alignment and mode-matching a beam into an optical cavity to 99.9%. This experiment paves the way for the correction of even higher order errors when paired with higher order wavefront actuators. Such a sensing scheme could find use in optimizing complex interferometers consisting of coupled cavities, such as those found in gravitational wave detectors, or simply just for sensing higher order wavefront errors in heterodyne interferometric table-top experiments.

Optical lock-in camera for gravitational wave detectors.

Knowledge of the intensity and phase profiles of spectral components in a coherent optical field is critical for a wide range of high-precision optical applications. One of these is interferometric gravitational wave detectors, which rely on the optical beats between these fields for precise control of the experiment. Here we describe an optical lock-in camera and show that it can be used to record optical beats at MHz or greater frequencies with higher spatial and temporal resolution than previously possible. This improvement is achieved using a Pockels cell as a fast optical switch to transform each pixel on a sCMOS array into an optical lock-in amplifier. We demonstrate that the optical lock-in camera can record fields with 2 Mpx resolution at 10 Hz with a sensitivity of -62 dBc when averaged over 2s.

Enhancing the dynamic range of deformable mirrors with compression bias.

We report the design and testing of a compression-biased thermally-actuated deformable mirror that has a dynamic range larger than the limit imposed by pure-bending stress, negligible higher-order-mode scattering, and a linear defocus response and that is vacuum compatible. The optimum design principles for this class of actuator are described and a mirror with 370 mD dynamic range is demonstrated.

High dynamic range thermally actuated bimorph mirror for gravitational wave detectors.

Adaptive optics are crucial for overcoming the fabrication limits on mirror curvature in high-precision interferometry. We describe a low-cost thermally actuated bimorph mirror with 200 mD linear response, which meets dynamic range and low aberration requirements for the ${\rm{A}} + $A+ upgrade of the Laser Interferometer Gravitational-wave Observatory (LIGO). Its deformation and operation limits were measured and verified against finite element simulation.

Clinical utility of (99m Tc)-TRODAT-1 scans to differentiate Parkinsonian syndromes: case studies and commentary.

The differential diagnosis of Parkinsonian syndromes is challenging, especially in the elderly as they often have complex presentations. Nuclear imaging modalities can increase diagnostic accuracy. Single-photon emission tomography (SPECT) using the ligand (99m Tc)-TRODAT-1 is used overseas but is yet to be approved in Australia. Three pilot cases of clinically unclear Parkinsonian syndromes from the Royal North Shore Hospital Aged Care Department who underwent (99m Tc)-TRODAT-1 scans are described. From experience overseas, the (99m Tc)-TRODAT-1 scan has clinical utility in the differential diagnosis of Parkinsonian syndromes. (99m Tc)-TRODAT-1 has a lower cost and greater availability than other ligands. Our initial scan findings are largely consistent with the clinical picture, but low specific binding can affect scan interpretation. (99m Tc)-TRODAT-1 is a potential tool in the differential diagnosis of Parkinsonian syndromes. Further experience regarding its effect on patient outcomes and cost effectiveness is required before routine clinical use can be recommended.

High power cryogenic Ho:YAG laser.

We have improved significantly the brightness of cryogenic Ho:YAG, reporting up to 65 W output power with a beam quality of M2 <1.3 and a slope efficiency of 71%. The laser emission was ~2 nm wide and centered at 2097.5 nm. This result demonstrates the scalability of both the narrow-line thulium fibre pump laser and the cryogenic laser head.

Short-pulse actively Q-switched Er:YAG lasers.

We report the shortest duration pulses obtained to date from an actively Q-switched Er:YAG laser pumped by a low spectral and spatial brightness laser diode. The 14.5 ns, 6 mJ pulses were obtained using a 1470 nm laser diode end-pumped co-planar folded zigzag slab architecture. We also present an analytical model that accurately predicts the pulse energy-duration product achievable from virtually all Q-switched Er:YAG lasers and high repetition rate quasi-three-level Q-switched lasers in general.

Efficient, low threshold, cryogenic Ho:YAG laser.

We report the development of an efficient, liquid-nitrogen conduction cooled Ho:YAG slab laser with good beam quality. Detailed measurements resolving the structure of the 1900-1911 nm absorption band in Ho:YAG at 77 K are presented. Stress-free conduction cooled mounting of the Ho:YAG slab was demonstrated and the resulting laser operated with a large mode volume of 42 mm3, a slope efficiency of 75% and a threshold of 0.84 W. To our knowledge this corresponds to the lowest reported threshold intensity for a Ho:YAG laser.

Compact cavity-dumped Q-switched Er:YAG laser.

We report a compact cavity-dumped Q-switched Er:YAG laser that produces pulses with 4.5 ns full width at half-maximum duration and 10 mJ energy. To the best of our knowledge, the resulting 2 MW peak power is the highest reported to date from a 1645 nm Er:YAG laser.

Overview of Advanced LIGO adaptive optics.

This is an overview of the adaptive optics used in Advanced LIGO (aLIGO), known as the thermal compensation system (TCS). The TCS was designed to minimize thermally induced spatial distortions in the interferometer optical modes and to provide some correction for static curvature errors in the core optics of aLIGO. The TCS is comprised of ring heater actuators, spatially tunable CO2 laser projectors, and Hartmann wavefront sensors. The system meets the requirements of correcting for nominal distortion in aLIGO to a maximum residual error of 5.4 nm rms, weighted across the laser beam, for up to 125 W of laser input power into the interferometer.

The British Transplantation Society guidelines on ethics, law and consent in relation to deceased donors after circulatory death.

The British Transplantation Society (BTS) 'Guideline on transplantation from deceased donors after circulatory death' has recently been updated and this manuscript summarises the relevant recommendations from chapters specifically related to law, ethics, donor consent and informing the recipient.

Cryogenic, high power, near diffraction limited, Yb:YAG slab laser.

A cryogenic slab laser that is suitable for scaling to high power, while taking full advantage of the improved thermo-optical and thermo-mechanical properties of Yb:YAG at cryogenic temperatures is described. The laser uses a conduction cooled, end pumped, zigzag slab geometry resulting in a near diffraction limited, robust, power scalable design. The design and the initial characterization of the laser up to 200W are presented.

Early changes in scores of chronic damage on transplant kidney protocol biopsies reflect donor characteristics, but not future graft function.

The amount of irreversible injury on renal allograft biopsy predicts function, but little is known about the early evolution of this damage. In a single-center cohort, we examined the relationship between donor-, recipient-, and transplantation-associated factors and change in a morphometric index of chronic damage (ICD) between protocol biopsies performed at implantation and at 2-3 months. We then investigated whether early delta ICD predicted subsequent biochemical outcomes. We found little evidence to support differences between the study group, who had undergone serial biopsies, and a contemporaneous control group, who had not. In allografts with serial biopsies (n = 162), there was an increase in ICD between implantation (median: 2%, IQR:0-8) and 2-3 months post-transplant (median 8% IQR:4-15; p < 0.0001). Donation from younger or live donors was independently associated with smaller early post-transplant increases in ICD. There was no evidence for a difference in delta ICD between donation after cardiac death vs. donation after brain death, nor association with length of cold ischemia. After adjustment for GFR at the time of the second biopsy, delta ICD after three months did not predict allograft function at one yr. These findings suggest that graft damage develops shortly after transplantation and reflects donor factors, but does not predict future biochemical outcomes.

Is laparoscopic donation safe for paediatric recipients?--a study of 85 paediatric recipients comparing open and laparoscopic donor nephrectomy.

INTRODUCTION: The safety of adult laparoscopic donor nephrectomy remains controversial with respect to paediatric recipients with few data existing about its efficacy. Small studies have shown no difference in graft survival when compared with open techniques, but previous data from United Network for Organ Sharing suggests a higher incidence of rejection in laparoscopically procured kidneys. METHODS: We examined the outcome in a total of 85 consecutive paediatric renal recipients, comparing 46 recipients of laparoscopically procured kidneys (performed over a 3-year period, 2004-07) to a historical control of 39 open donor recipients. Thirty-seven laparoscopic donors were by the hand-assisted technique. RESULTS: Mean recipient age was 9.8 (SD 5.04) years in the laparoscopic group and 10.4 (SD 4.67) years in the open group (P = 0.617). Two patients had delayed graft function in the laparoscopic group (4.3%) and one (2.5%) in the open group (P = 0.562). At 1 year follow-up, there was 100% graft survival in the laparoscopic group compared to 92% (P = 0.093) in the open group. Incidence of biopsy-proven acute rejection within 1 year of transplant was 26% (16 episodes in 12 patients) in the laparoscopic group compared to 41% (29 episodes in 16 patients) in the open group (P = 0.219). There were no deaths in the laparoscopic group but there were three deaths (7.6%) in the open group (P = 0.093). CONCLUSIONS: Our experience of laparoscopic kidney donation for paediatric recipients suggests excellent outcome with no difference in rejection rate or graft survival compared to open donation. Laparoscopic donation is the optimal method of kidney procurement for paediatric recipients.

Single-pulse measurement of wind velocities using an Er:Yb:glass coherent laser radar.

Many wind-field mapping applications require range-resolved atmospheric velocity measurements at long range and/or with a temporal resolution sufficient to investigate turbulence. We argue that this capability can be achieved only by coherent laser radar systems that transmit energetic (>1 mJ) pulses. We describe such a system and describe single-pulse measurement of the range-resolved line-of-sight velocities, and show that the instrument-limited reproducibility of the measurements is 0.4 ms(-1).

Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms.

In patients with chronic kidney disease, high plasma levels of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, are thought to contribute to decline in renal function. Here we took a candidate gene approach to determine any causal role of asymmetric dimethylarginine in the progression of chronic kidney disease. The impact of single-nucleotide polymorphisms in the genes encoding the two isoforms of the asymmetric dimethylarginine-degrading enzyme, dimethylarginine dimethylaminohydrolase (DDAH1 and DDAH2), on enzyme expression, plasma asymmetric dimethylarginine levels, and longitudinal changes in estimated glomerular filtration rate were determined in various patient groups. There was evidence suggesting that the rs17384213 DDAH1 GG genotype was associated with increased expression of its mRNA in kidney allografts. Healthy subjects carrying the rs17384213 G allele had lower plasma asymmetric dimethylarginine, and a similar borderline association was found in patients with chronic kidney disease. This allele, however, was independently associated with a steeper decline in renal function in two separate cohorts of patients with chronic kidney disease. We conclude that polymorphisms in DDAH1 alter the rate of decline of glomerular filtration rate in subjects with chronic kidney disease. Our findings show that DDAH1 modulates plasma asymmetric dimethylarginine and contributes to the decline in renal function. However, it appears that increases in circulating methylarginine did not mediate progressive kidney injury.

Hyperamylasemia Post Living Donor Nephrectomy Does Not Relate to Pain.

Introduction The aetiology of pain after laparoscopic donor nephrectomy remains unclear. Given the proximity of the left kidney to the tail of the pancreas, we aimed to assess whether mobilisation and retrieval of the left kidney might inflame the pancreas, leading to pain and hyperamylasaemia in the post-operative period. Patient and methods In the present study, 16 consecutive live kidney donors were analysed in the same three months period. Amylase levels were measured on days 1 and 2. For each 24-hour period post-operatively analgesia consumption was recorded, as well as pain scores at rest on a visual analogue scale (VAS). Results Three out of 16 donors presented hyperamylasemia. A multiple regression analysis found levobupivacaine dose, propofol dose, transversus abdominis plane block and day 1 amylase did not significantly predict pain scores. Interestingly, body mass index significantly correlated with increased pain scores (p = 0.041). Also, increasing CO2 insufflation pressure and use of local anaesthetic infusion catheters predicted a decreased deep pain score (p = 0.036 and p = 0.037). Conclusion There was no correlation of amylase levels and pain scores. Pancreatitis is a rare complication of nephrectomy and no overt cases were seen in the case of donor nephrectomy.

Direct measurement of absorption-induced wavefront distortion in high optical power systems.

Wavefront distortion due to absorption in the substrates and coatings of mirrors in advanced gravitational wave interferometers has the potential to compromise the operation and sensitivity of these interferometers [Opt. Lett.29, 2635-2637 (2004)]. We report the first direct spatially-resolved measurement, to our knowledge, of such wavefront distortion in a high optical power cavity. The measurement was made using an ultrahigh sensitivity Hartmann wavefront sensor on a dedicated test facility. The sensitivity of the sensor was lambda/730, where lambda=800 nm.

Injection mode-locked guide star laser concept and design verification experiments.

Injection mode-locking combined with stretched Q-switching of a ring resonator are proposed and demonstrated as a promising approach for advanced, guide star lasers. The concept uses two Nd:YAG lasers, producing a macro-micro pulse-burst output, optimized for efficient sum-frequency generation. We demonstrate wavelength, bandwidth and timing control required to maximize the atmospheric Na fluorescence.