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1.

Event-free survival of maralixibat-treated patients with Alagille syndrome compared to a real-world cohort from GALA.

Hansen, Bettina E; Vandriel, Shannon M; Vig, Pamela; Garner, Will; Mogul, Douglas B; Loomes, Kathleen M; Piccoli, David A; Rand, Elizabeth B; Jankowska, Irena; Czubkowski, Piotr; Gliwicz-Miedzinska, Dorota; Gonzales, Emmanuel M; Jacquemin, Emmanuel; Bouligand, Jérôme; D'Antiga, Lorenzo; Nicastro, Emanuele; Arnell, Henrik; Fischler, Björn; Sokal, Étienne; Demaret, Tanguy; Siew, Susan; Stormon, Michael; Karpen, Saul J; Romero, Rene; Ebel, Noelle H; Feinstein, Jeffrey A; Roberts, Amin J; Evans, Helen M; Sundaram, Shikha S; Chaidez, Alexander; Hardikar, Winita; Shankar, Sahana; Fischer, Ryan T; Lacaille, Florence; Debray, Dominique; Lin, Henry C; Jensen, M Kyle; Jaramillo, Catalina; Karthikeyan, Palaniswamy; Indolfi, Giuseppe; Verkade, Henkjan J; Larson-Nath, Catherine; Quiros-Tejeira, Ruben E; Valentino, Pamela L; Rogalidou, Maria; Dezsofi, Antal; Squires, James E; Schwarz, Kathleen; Calvo, Pier Luigi; Bernabeu, Jesus Quintero.

Hepatology; 79(6): 1279-1292, 2024 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-38146932

2.

Predictors of 6-year event-free survival in Alagille syndrome patients treated with maralixibat, an ileal bile acid transporter inhibitor.

Sokol, Ronald J; Gonzales, Emmanuel M; Kamath, Binita M; Baker, Alastair; Vig, Pamela; Mogul, Douglas B; Garner, Will; Hansen, Bettina E; Jacquemin, Emmanuel; Thompson, Richard J.

Hepatology; 78(6): 1698-1710, 2023 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-37278241

3.

Maralixibat Treatment Response in Alagille Syndrome is Associated with Improved Health-Related Quality of Life.

Kamath, Binita M; Goldstein, Andrea; Howard, Robin; Garner, Will; Vig, Pamela; Marden, Jessica R; Billmyer, Emma; Anderson, Annika; Kirson, Noam; Jacquemin, Emmanuel; Gonzales, Emmanuel.

J Pediatr; 252: 68-75.e5, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36096175

4.

Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study.

Gonzales, Emmanuel; Hardikar, Winita; Stormon, Michael; Baker, Alastair; Hierro, Loreto; Gliwicz, Dorota; Lacaille, Florence; Lachaux, Alain; Sturm, Ekkehard; Setchell, Kenneth D R; Kennedy, Ciara; Dorenbaum, Alejandro; Steinmetz, Jana; Desai, Nirav K; Wardle, Andrew J; Garner, Will; Vig, Pamela; Jaecklin, Thomas; Sokal, Etienne M; Jacquemin, Emmanuel.

Lancet; 398(10311): 1581-1592, 2021 10 30.

Artículo en Inglés | MEDLINE | ID: mdl-34755627

5.

Comparison of ADAPT, FIB-4 and APRI as non-invasive predictors of liver fibrosis and NASH within the CENTAUR screening population.

Nielsen, Mette Juul; Leeming, Diana Julie; Goodman, Zachary; Friedman, Scott; Frederiksen, Peder; Rasmussen, Daniel Guldager Kring; Vig, Pamela; Seyedkazemi, Star; Fischer, Laurent; Torstenson, Richard; Karsdal, Morten Asser; Lefebvre, Eric; Sanyal, Arun J; Ratziu, Vlad.

J Hepatol; 75(6): 1292-1300, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-34454994

6.

Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice.

Ambade, Aditya; Lowe, Patrick; Kodys, Karen; Catalano, Donna; Gyongyosi, Benedek; Cho, Yeonhee; Iracheta-Vellve, Arvin; Adejumo, Adeyinka; Saha, Banishree; Calenda, Charles; Mehta, Jeeval; Lefebvre, Eric; Vig, Pamela; Szabo, Gyongyi.

Hepatology; 69(3): 1105-1121, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30179264

7.

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.

Friedman, Scott L; Ratziu, Vlad; Harrison, Stephen A; Abdelmalek, Manal F; Aithal, Guruprasad P; Caballeria, Juan; Francque, Sven; Farrell, Geoffrey; Kowdley, Kris V; Craxi, Antonio; Simon, Krzysztof; Fischer, Laurent; Melchor-Khan, Liza; Vest, Jeffrey; Wiens, Brian L; Vig, Pamela; Seyedkazemi, Star; Goodman, Zachary; Wong, Vincent Wai-Sun; Loomba, Rohit; Tacke, Frank; Sanyal, Arun; Lefebvre, Eric.

Hepatology; 67(5): 1754-1767, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-28833331

8.

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.

Guicciardi, Maria Eugenia; Trussoni, Christy E; Krishnan, Anuradha; Bronk, Steven F; Lorenzo Pisarello, Maria J; O'Hara, Steven P; Splinter, Patrick L; Gao, Yandong; Vig, Pamela; Revzin, Alexander; LaRusso, Nicholas F; Gores, Gregory J.

J Hepatol; 69(3): 676-686, 2018 09.

Artículo en Inglés | MEDLINE | ID: mdl-29802947

9.

Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents.

Yu, Dongke; Cai, Shi-Ying; Mennone, Albert; Vig, Pamela; Boyer, James L.

Liver Int; 38(6): 1128-1138, 2018 06.

Artículo en Inglés | MEDLINE | ID: mdl-29356312

10.

Effectiveness of ravidasvir plus sofosbuvir in interferon-naïve and treated patients with chronic hepatitis C genotype-4.

Esmat, Gamal; Elbaz, Tamer; El Raziky, Maissa; Gomaa, Asmaa; Abouelkhair, Mahmoud; Gamal El Deen, Hadeel; Sabry, Aliaa; Ashour, Mohamed; Allam, Naglaa; Abdel-Hamid, Mohamed; Nada, Ola; Helmy, Sherine; Abdel-Maguid, Hanaa; Colonno, Richard; Brown, Nathaniel; Ruby, Eric; Vig, Pamela; Waked, Imam.

J Hepatol; 2017 Sep 19.

Artículo en Inglés | MEDLINE | ID: mdl-28935432

11.

Maralixibat in progressive familial intrahepatic cholestasis (MARCH-PFIC): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

Miethke, Alexander G; Moukarzel, Adib; Porta, Gilda; Covarrubias Esquer, Joshue; Czubkowski, Piotr; Ordonez, Felipe; Mosca, Antonella; Aqul, Amal A; Squires, Robert H; Sokal, Etienne; D'Agostino, Daniel; Baumann, Ulrich; D'Antiga, Lorenzo; Kasi, Nagraj; Laborde, Nolwenn; Arikan, Cigdem; Lin, Chuan-Hao; Gilmour, Susan; Mittal, Naveen; Chiou, Fang Kuan; Horslen, Simon P; Huber, Wolf-Dietrich; Jaecklin, Thomas; Nunes, Tiago; Lascau, Anamaria; Longpre, Lara; Mogul, Douglas B; Garner, Will; Vig, Pamela; Hupertz, Vera F; Gonzalez-Peralta, Regino P; Ekong, Udeme; Hartley, Jane; Laverdure, Noemie; Ovchinsky, Nadia; Thompson, Richard J.

Lancet Gastroenterol Hepatol; 2024 May 06.

Artículo en Inglés | MEDLINE | ID: mdl-38723644

12.

Safety, tolerability, and efficacy of maralixibat in adults with primary sclerosing cholangitis: Open-label pilot study.

Bowlus, Christopher L; Eksteen, Bertus; Cheung, Angela C; Thorburn, Douglas; Moylan, Cynthia A; Pockros, Paul J; Forman, Lisa M; Dorenbaum, Alejandro; Hirschfield, Gideon M; Kennedy, Ciara; Jaecklin, Thomas; McKibben, Andrew; Chien, Elaine; Baek, Marshall; Vig, Pamela; Levy, Cynthia.

Hepatol Commun; 7(6)2023 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-37184523

13.

Serum Bile Acid Profiling and Mixed Model Analysis Reveal Biomarkers Associated with Pruritus Reduction in Maralixibat-Treated Patients with BSEP Deficiency.

Zhao, Xueheng; Zhang, Wujuan; Vig, Pamela; Kostrub, Cory; Setchell, Kenneth D R.

Metabolites; 12(10)2022 Oct 06.

Artículo en Inglés | MEDLINE | ID: mdl-36295854

14.

Maralixibat for the treatment of PFIC: Long-term, IBAT inhibition in an open-label, Phase 2 study.

Loomes, Kathleen M; Squires, Robert H; Kelly, Deirdre; Rajwal, Sanjay; Soufi, Nisreen; Lachaux, Alain; Jankowska, Irena; Mack, Cara; Setchell, Kenneth D R; Karthikeyan, Palaniswamy; Kennedy, Ciara; Dorenbaum, Alejandro; Desai, Nirav K; Garner, Will; Jaecklin, Thomas; Vig, Pamela; Miethke, Alexander; Thompson, Richard J.

Hepatol Commun; 6(9): 2379-2390, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35507739

15.

Efficacy and Safety of Cenicriviroc in Patients With Primary Sclerosing Cholangitis: PERSEUS Study.

Eksteen, Bertus; Bowlus, Christopher L; Montano-Loza, Aldo J; Lefebvre, Eric; Fischer, Laurent; Vig, Pamela; Martins, Eduardo Bruno; Ahmad, Jawad; Yimam, Kidist K; Pockros, Paul J; Feld, Jordan J; Minuk, Gerald; Levy, Cynthia.

Hepatol Commun; 5(3): 478-490, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33681680

16.

The Critical Role of Chemokine (C-C Motif) Receptor 2-Positive Monocytes in Autoimmune Cholangitis.

Reuveni, Debby; Gore, Yael; Leung, Patrick S C; Lichter, Yael; Moshkovits, Itay; Kaminitz, Ayelet; Brazowski, Eli; Lefebvre, Eric; Vig, Pamela; Varol, Chen; Halpern, Zamir; Shibolet, Oren; Gershwin, Merrill Eric; Zigmond, Ehud.

Front Immunol; 9: 1852, 2018.

Artículo en Inglés | MEDLINE | ID: mdl-30158929

17.

Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1.

Benhamou, Yves; Thibault, Vincent; Vig, Pamela; Calvez, Vincent; Marcelin, Anne-Genevieve; Fievet, Marie-Hélène; Currie, Graeme; Chang, Chuy G; Biao, Lu; Xiong, Shelly; Brosgart, Carol; Poynard, Thierry.

J Hepatol; 44(1): 62-7, 2006 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-16274835

18.

The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice.

Vig, Pamela; Russo, Francesco P; Edwards, Robert J; Tadrous, Paul J; Wright, Nicholas A; Thomas, Howard C; Alison, Malcolm R; Forbes, Stuart J.

Hepatology; 43(2): 316-24, 2006 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-16440343

19.

Hepatic stem cells.

Forbes, Stuart; Vig, Pamela; Poulsom, Richard; Thomas, Howard; Alison, Malcolm.

J Pathol; 197(4): 510-8, 2002 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-12115866

20.

Adult stem cell plasticity: new pathways of tissue regeneration become visible.

Forbes, Stuart J; Vig, Pamela; Poulsom, Richard; Wright, Nicholas A; Alison, Malcolm R.

Clin Sci (Lond); 103(4): 355-69, 2002 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-12241534

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