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1.

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.

Mosca, Matthieu; Hermange, Gurvan; Tisserand, Amandine; Noble, Robert; Marzac, Christophe; Marty, Caroline; Le Sueur, Cécile; Campario, Hugo; Vertenoeil, Gaëlle; El-Khoury, Mira; Catelain, Cyril; Rameau, Philippe; Gella, Cyril; Lenglet, Julien; Casadevall, Nicole; Favier, Rémi; Solary, Eric; Cassinat, Bruno; Kiladjian, Jean-Jacques; Constantinescu, Stefan N; Pasquier, Florence; Hochberg, Michael E; Raslova, Hana; Villeval, Jean-Luc; Girodon, François; Vainchenker, William; Cournède, Paul-Henry; Plo, Isabelle.

Blood; 138(22): 2231-2243, 2021 12 02.

Artículo en Inglés | MEDLINE | ID: mdl-34407546

2.

Vascular endothelial cell expression of JAK2^V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression.

Guy, Alexandre; Gourdou-Latyszenok, Virginie; Le Lay, Nicolas; Peghaire, Claire; Kilani, Badr; Dias, Juliana Vieira; Duplaa, Cécile; Renault, Marie-Ange; Denis, Cécile; Villeval, Jean Luc; Boulaftali, Yacine; Jandrot-Perrus, Martine; Couffinhal, Thierry; James, Chloe.

Haematologica; 104(1): 70-81, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30171023

3.

Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis.

Erba, Benedetta Gaia; Gruppi, Cristian; Corada, Monica; Pisati, Federica; Rosti, Vittorio; Bartalucci, Niccolo'; Villeval, Jean-Luc; Vannucchi, Alessandro Maria; Barosi, Giovanni; Balduini, Alessandra; Dejana, Elisabetta.

Am J Pathol; 187(8): 1879-1892, 2017 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-28728747

4.

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.

Marty, Caroline; Pecquet, Christian; Nivarthi, Harini; El-Khoury, Mira; Chachoua, Ilyas; Tulliez, Micheline; Villeval, Jean-Luc; Raslova, Hana; Kralovics, Robert; Constantinescu, Stefan N; Plo, Isabelle; Vainchenker, William.

Blood; 127(10): 1317-24, 2016 Mar 10.

Artículo en Inglés | MEDLINE | ID: mdl-26608331

5.

Megakaryocytes tame erythropoiesis with TGFß1.

Villeval, Jean-Luc; Vainchenker, William.

Blood; 136(9): 1016-1017, 2020 08 27.

Artículo en Inglés | MEDLINE | ID: mdl-32853376

6.

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm.

Lamrani, Lamia; Lacout, Catherine; Ollivier, Véronique; Denis, Cécile V; Gardiner, Elizabeth; Ho Tin Noe, Benoit; Vainchenker, William; Villeval, Jean-Luc; Jandrot-Perrus, Martine.

Blood; 124(7): 1136-45, 2014 Aug 14.

Artículo en Inglés | MEDLINE | ID: mdl-24951423

7.

JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice.

Debeurme, Franck; Lacout, Catherine; Moratal, Claudine; Bagley, Rebecca G; Vainchenker, William; Adrian, Francisco; Villeval, Jean-Luc.

J Cell Mol Med; 19(11): 2564-74, 2015 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-26176817

8.

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

Hasan, Salma; Lacout, Catherine; Marty, Caroline; Cuingnet, Marie; Solary, Eric; Vainchenker, William; Villeval, Jean-Luc.

Blood; 122(8): 1464-77, 2013 Aug 22.

Artículo en Inglés | MEDLINE | ID: mdl-23863895

9.

The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.

Gautier, Emilie-Fleur; Picard, Muriel; Laurent, Camille; Marty, Caroline; Villeval, Jean-Luc; Demur, Cécile; Delhommeau, François; Hexner, Elizabeth; Giraudier, Stéphane; Bonnevialle, Nicolas; Ducommun, Bernard; Récher, Christian; Laurent, Guy; Manenti, Stéphane; Mansat-De Mas, Véronique.

Blood; 119(5): 1190-9, 2012 Feb 02.

Artículo en Inglés | MEDLINE | ID: mdl-22065597

10.

Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.

Pecquet, Christian; Diaconu, Carmen C; Staerk, Judith; Girardot, Michael; Marty, Caroline; Royer, Yohan; Defour, Jean-Philippe; Dusa, Alexandra; Besancenot, Rodolphe; Giraudier, Stephane; Villeval, Jean-Luc; Knoops, Laurent; Courtoy, Pierre J; Vainchenker, William; Constantinescu, Stefan N.

Blood; 119(20): 4625-35, 2012 May 17.

Artículo en Inglés | MEDLINE | ID: mdl-22378845

11.

Exacerbation of thrombo-inflammation by JAK2V617F mutation worsens the prognosis of cerebral venous sinus thrombosis.

Bourrienne, Marie-Charlotte; Le Cam Duchez, Véronique; Faille, Dorothée; Farkh, Carine; Solo Nomenjanahary, Mialitiana; Gay, Juliette; Loyau, Stéphane; Journé, Clément; Dupont, Sébastien; Ollivier, Véronique; Villeval, Jean-Luc J-L; Plo, Isabelle; Edmond, Valérie; Jandrot-Perrus, Martine; Labrouche-Colomer, Sylvie; Cassinat, Bruno; Verger, Emmanuelle; Desilles, Jean-Philippe; Ho Tin Noé, Benoît Ho; Triquenot Bagan, Aude; Mazighi, Mikaël; Ajzenberg, Nadine.

Blood Adv; 2024 Feb 22.

Artículo en Inglés | MEDLINE | ID: mdl-38386979

12.

Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms.

Bartalucci, Niccolò; Tozzi, Lorenzo; Bogani, Costanza; Martinelli, Serena; Rotunno, Giada; Villeval, Jean-Luc; Vannucchi, Alessandro M.

J Cell Mol Med; 17(11): 1385-96, 2013 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-24237791

13.

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.

Choong, Meng Ling; Pecquet, Christian; Pendharkar, Vishal; Diaconu, Carmen C; Yong, Jacklyn Wei Yan; Tai, Shi Jing; Wang, Si Fang; Defour, Jean-Philippe; Sangthongpitag, Kanda; Villeval, Jean-Luc; Vainchenker, William; Constantinescu, Stefan N; Lee, May Ann.

J Cell Mol Med; 17(11): 1397-409, 2013 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-24251790

14.

Endothelial JAK2^V617F does not enhance liver lesions in mice with Budd-Chiari syndrome.

Poisson, Johanne; Hilscher, Moira B; Tanguy, Marion; Hammoutene, Adel; Boulanger, Chantal M; Villeval, Jean-Luc; Simonetto, Douglas A; Valla, Dominique; Shah, Vijay H; Rautou, Pierre-Emmanuel.

J Hepatol; 68(5): 1086-1087, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29360553

15.

Thrombospondin-1 is not the major activator of TGF-ß1 in thrombopoietin-induced myelofibrosis.

Evrard, Solène; Bluteau, Olivier; Tulliez, Micheline; Rameau, Philippe; Gonin, Patrick; Zetterberg, Eva; Palmblad, Jan; Bonnefoy, Arnaud; Villeval, Jean-Luc; Vainchenker, William; Giraudier, Stéphane; Wagner-Ballon, Orianne.

Blood; 117(1): 246-9, 2011 Jan 06.

Artículo en Inglés | MEDLINE | ID: mdl-20944070

16.

SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.

Willekens, Christophe; Laplane, Lucie; Dagher, Tracy; Benlabiod, Camelia; Papadopoulos, Nicolas; Lacout, Catherine; Rameau, Philippe; Catelain, Cyril; Alfaro, Alexia; Edmond, Valérie; Signolle, Nicolas; Marchand, Valentine; Droin, Nathalie; Hoogenboezem, Remco; Schneider, Rebekka K; Penson, Alex; Abdel-Wahab, Omar; Giraudier, Stephane; Pasquier, Florence; Marty, Caroline; Plo, Isabelle; Villeval, Jean-Luc; Constantinescu, Stefan N; Porteu, Françoise; Vainchenker, William; Solary, Eric.

Leukemia; 37(6): 1287-1297, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-37100881

17.

Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation.

Poirault-Chassac, Sonia; Six, Emmanuelle; Catelain, Cyril; Lavergne, Mélanie; Villeval, Jean-Luc; Vainchenker, William; Lauret, Evelyne.

Blood; 116(25): 5670-8, 2010 Dec 16.

Artículo en Inglés | MEDLINE | ID: mdl-20829371

18.

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

Marty, Caroline; Lacout, Catherine; Martin, Antoine; Hasan, Salma; Jacquot, Sylvie; Birling, Marie-Christine; Vainchenker, William; Villeval, Jean-Luc.

Blood; 116(5): 783-7, 2010 Aug 05.

Artículo en Inglés | MEDLINE | ID: mdl-20472827

19.

Lessons from mouse models of MPN.

Benlabiod, Camelia; Dagher, Tracy; Marty, Caroline; Villeval, Jean-Luc.

Int Rev Cell Mol Biol; 366: 125-185, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35153003

20.

In Vivo Monitoring of Polycythemia Vera Development Reveals Carbonic Anhydrase 1 as a Potent Therapeutic Target.

Murakami, Shohei; Barroca, Vilma; Perié, Leïla; Bravard, Anne; Bernardino-Sgherri, Jacqueline; Tisserand, Amandine; Devanand, Caroline; Edmond, Valérie; Magniez, Aurélie; Tenreira Bento, Sabrina; Torres, Claire; Pasquier, Florence; Plo, Isabelle; Vainchenker, William; Villeval, Jean-Luc; Roméo, Paul-Henri; Lewandowski, Daniel.

Blood Cancer Discov; 3(4): 285-297, 2022 07 06.

Artículo en Inglés | MEDLINE | ID: mdl-35290450

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